Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

6533b839fe1ef96bd12a6b71

RESEARCH PRODUCT

Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database

Boyle A. J.Madotto F.Laffey J. G.Bellani G.Pham T.Pesenti A.Thompson B. T.O'kane C. M.Deane A. M.Mcauley D. F Rios F Van Haren F Faruq Mo Sottiaux T Depuydt P Lora Fs Azevedo Lc Fan E Bugedo G Qiu H Gonzalez M Silesky J Cerny V Nielsen J Jibaja M Pham T Wrigge H Matamis D Ranero Jl Gomersall C Amin P Hashemian Sm Clarkson K Bellani G Kurahashi K Koh Y Villagomez A Zeggwagh Aa Heunks Lm Laake Jh Kashif W Synclair J Palo Je Do Vale Fernandes A Sandesc D Arabi Y Bumbasierevic V Nin N Lorente Ja Larsson A Piquilloud L Patjanasoontorn B Abroug F Mcauley Df Mcnamee L Hurtado J Bajwa E Démpaire G Francois Gm Rabboni F Conti S Sula H Cani A Zazu A Dellera C Alejandro Rv Daldin J Fernandez Ro Cardonnet Lp Bettini Lr Bisso Mc Osman Em Setten Mg Lovazzano P Alvarez J Villar V Pozo Nc Grubissich N Plotnikow Ga Vasquez Dn Ilutovich S Tiribelli N Chena A Pellegrini Ca Saenz Mg Estenssoro E Brizuela M Gianinetto H Gomez Pe Cerrato Vi Bezzi Mg Borello Sa Loiacono Fa Fernandez Am Knowles S Reynolds C Inskip Dm Miller Jj Kong J Whitehead C Bihari S Seven A Krstevski A Rodgers Hj Millar Rt Mckenna Te Bailey Im Hanlon Gc Aneman A Lynch Jm Azad R Neal J Woods Pw Roberts Bl Kol Mr Wong Hs Riss Kc Staudinger T Wittebole X Bulpa Pa Dive Am Verstraete R Lebbinck H Depuydt P Vermassen J Philippe M Ceunen H Rosa Ji Beraldo Do Piras C Rampinelli Am Nassar Ap Jr Mataloun S Moock M Thompson Mm Gonçalves Ch Antônio Acp Ascoli A Biondi Rs Fontenele Dc Nobrega D Sales Vm Shindhe S Pg Hj Ismail Dmab Laffey J Beloncle F Davies Kg Cirone R Manoharan V Ismail M Goligher Ec Jassal M Ferguson Nd Nishikawa E Javeed A Curley G Rittayamai N Parotto M Mehta S Knoll J Pronovost A Bruhn Scar Garcia Ph Aliaga Fa Farías Pa Yumha Js Ortiz Ca Salas Je Saez Aa Vega Ld Labarca Ef Martinez Ft Carreño Ng Lora P Liu H Qiu H Liu L Tang R Luo X An Y Zhao H Gao Y Zhai Z Ye Zl Wang W Li W Li Q Zheng R Yu W Shen J Li X Yu T Lu W Wu Yq Huang Xb He Z Lu Y Han H Zhang F Sun R Wang Hx Qin Sh Zhu Bh Zhao J Liu J Li B Liu Jl Zhou Fc Li Qj Zhang Xy Li-xin Z Xin-hua Q Jiang L Gao Yn Zhao Xy Li Yy Li Xl Wang C Yao Q Yu R Chen K Shao H Qin B Huang Qq Zhu Wh Hang Ay Hua Mx Li Y Xu Y Di Yd Ling Ll Qin Th Wang Sh Qin J Han Y Zhou S Vargas Mp Silesky Jimenez Ji González Rojas Ma Solis-quesada Je Ramirez-alfaro Cm Máca J Sklienka P Gjedsted J Christiansen A Rigshopitalet Nielsen J Villamagua Bg Llano M Burtin P Buzancais G Beuret P Pelletier N Mortaza S Mercat A Chelly J Jochmans S Terzi N Daubin C Carteaux G De Prost N Chiche Jd Daviaud F Pham T Fartoukh M Barberet G Biehler J Dellamonica J Doyen D Arnal Jm Briquet A Klasen F Papazian L Follin A Roux D Messika J Kalaitzis E Dangers L Combes A Au Sm Béduneau G Carpentier D Zogheib Eh Dupont H Ricome S Santoli Fl Besset Sl Michel P Gelée B Danin Pe Goubaux B Crova Pj Phan Nt Berkelmans F Badie Jc Tapponnier R Gally J Khebbeb S Herbrecht Je Schneider F Declercq Pm Rigaud Jp Duranteau J Harrois A Chabanne R Marin J Constantin Jm Thibault S Ghazi M Boukhazna M Zein So Richecoeur Jr Combaux Dm Grelon F Le Moal C Sauvadet Ep Robine A Lemiale V Reuter D Dres M Demoule A Goldgran-toledano D Baboi L Guérin C Lohner R Kraßler J Schäfer S Zacharowski Kd Meybohm P Reske Aw Simon P Hopf Hf Schuetz M Baltus T Papanikolaou Mn Papavasilopoulou Tg Zacharas Ga Ourailogloy V Mouloudi Ek Massa Ev Nagy Eo Stamou Ee Kiourtzieva Ev Oikonomou Ma Avila Le Cortez Ca Citalán Je Jog Sa Sable Sd Shah B Gurjar M Baronia Ak Memon M Muthuchellappan R Ramesh Vj Shenoy A Unnikrishnan R Dixit Sb Rhayakar Rv Ramakrishnan N Bhardwaj Vk Mahto Hl Sagar Sv Palaniswamy V Ganesan D Hashemian Sm Jamaati H Heidari F Meaney Ea Nichol A Knapman Km O'croinin D Dunne Es Breen Dm Clarkson Kp Jaafar Rf Dwyer R Amir F Ajetunmobi Oo O'muircheartaigh Ac Black Cs Treanor N Collins Dv Altaf W Zani G Fusari M Spadaro S Volta Ca Graziani R Brunettini B Palmese S Formenti P Umbrello M Lombardo A Pecci E Botteri M Savioli M Protti A Mattei A Schiavoni L Tinnirello A Todeschini M Giarratano A Cortegiani A Sher S Rossi A Antonelli Mm Montini Lm Casalena P Scafetti S Panarello G Occhipinti G Patroniti N Pozzi M Biscione Rr Poli Mm Raimondi F Albiero D Crapelli G Beck E Pota V Schiavone V Molin A Tarantino F Monti G Frati E Mirabella L Cinnella G Fossali T Colombo R Pattarino Pti Mojoli F Braschi A Borotto Ee Cracchiolo An Palma Dm Raponi F Foti G Vascotto Er Coppadoro A Brazzi L Floris L Iotti Ga Venti A Yamaguchi O Takagi S Maeyama Hn Watanabe E Yamaji Y Shimizu K Shiozaki K Futami S Ryosuke S Saito K Kameyama Y Ueno K Izawa M Okuda N Suzuki H Harasawa T Nasu M Takada T Ito F Nunomiya S Koyama K Abe T Andoh K Kusumoto K Hirata A Takaba A Kimura H Matsumoto S Higashijima U Honda H Aoki N Imai H Ogino Y Mizuguchi I Ichikado K Nitta K Mochizuki K Hashida T Tanaka H Nakamura T Niimi D Ueda T Kashiwa Y Uchiyama A Sabelnikovs O Oss P Haddad Y Liew Ky ÑAmendys-silva Sa Jarquin-badiola Yd Sanchez-hurtado La Gomez-flores Ss Marin Mc Villagomez Aj Lemus Js Fierro Jm Cervantes Mr Mejia Fjf Dector D Dector Dm Gonzalez Dr Estrella Cr Sanchez-medina Jr Ramirez-gutierrez A George Fg Aguirre Js Buensuseso Ja Poblano M Dendane T Zeggwagh Aa Balkhi H Elkhayari M Samkaoui N Ezzouine H Benslama A Amor M Maazouzi W Cimic N Beck O Bruns Mm Schouten Ja Rinia M Raaijmakers M Heunks Lm Van Wezel Hm Heines Sj Strauch U Buise Mp Simonis Fd Schultz Mj Goodson Jc Browne Ts Navarra L Hunt A Hutchison Ra Bailey Mb Newby L Mcarthur C Kalkoff M Mcleod A Casement J Hacking Dj Andersen Fh Dolva Ms Laake Jh Barratt-due A Noremark Kal Søreide E Sjøbø Bå Guttormsen Ab Leon Yoshido Hh Aguilar Rz Montes Oscanoa Fa Alisasis Au Robles Jb Pasanting-lim Rab Tan Bc Andruszkiewicz P Jakubowska K Coxo Cm Alvarez Am Oliveira Bs Montanha Gm Barros Nc Pereira Cs Messias Am Monteiro Jm Araujo Am Catorze Nt Marum Sm Bouw Mj Gomes Rm Brito Va Castro S Estilita Jm Barros Fm Serra Im Martinho Am Tomescu Dr Marcu A Bedreag Oh Papurica M Corneci De Negoita Si Grigoriev E Gritsan Ai Gazenkampf Aa Almekhlafi G Albarrak Mm Mustafa Gm Maghrabi Ka Salahuddin N Aisa Tm Al Jabbary As Tabhan E Arabi Ym Arabi Ym Trinidad Oa Al Dorzi Hm Tabhan Ee Bolon S Smith O Mancebo J Aguirre-bermeo H Lopez-delgado Jc Esteve F Rialp G Forteza C De Haro C Artigas A Albaiceta Gm De Cima-iglesias S Seoane-quiroga L Ceniceros-barros A Ruiz-aguilar Al Claraco-vega Lm Soler Ja Del Carmen Lorente M Hermosa C Gordo F Prieto-gonzález M López-messa Jb Perez Mp Perez Cp Allue Rm Roche-campo F Ibañez-santacruz M Temprano S Pintado Mc De Pablo R Gómez Pra Ruiz Sr Moles Si Jurado Mt Arizmendi A Piacentini Ea Franco N Honrubia T Cheng Mp Losada Ep Blanco J Yuste Lj Carbayo-gorriz C Cazorla-barranquero Fg Alonso Jg Alda Rs Algaba Á Navarro G Cereijo E Diaz-rodriguez E Marcos Dp Montero La Para Lh Sanchez Rj Navalpotro Mab Abad Rd González Rm Toribio Dp Castro Ag Artiga Mjd Penuelas O Roser Tp Olga Mf Curto Eg Sánchez Rm Imma Vp Elisabet Gm Claverias L Magret M Pellicer Am Rodriguez Ll Sánchez-ballesteros J González-salamanca Á Jimenez Ag Huerta Fp Llinares Moya Dd Tallet Alfonso Aa Luis Pse Cesar Ps Rafael Si Virgilio Cg Recio Nn Adamsson Ro Rylander Cc Holzgraefe B Broman Lm Wessbergh J Persson L Schiöler F Kedelv H Tibblin Ao Appelberg H Hedlund L Helleberg J Eriksson Ke Glietsch R Larsson N Nygren I Nunes Sl Morin Ak Kander T Adolfsson A Piquilloud L Zender Ho Leemann-refondini C Elatrous S Bouchoucha S Chouchene I Ouanes I Souissi Ab Kamoun S Demirkiran O Aker M Erbabacan E Ceylan I Girgin Nk Ozcelik M ÜNal N Meco Bc Akyol Oo Derman Ss Kennedy B Parhar K Srinivasa L Mcnamee L Mcauley D Hopkins P Mellis C Kakar V Hadfield D Vercueil A Bhowmick K Humphreys Sk Ferguson A Mckee R Raj As Fawkes Da Watt P Twohey L Jhamatthew Thomas Rr Morton A Kadaba V Smith Mj Hormis Ap Kannan Sg Namih M Reschreiter H Camsooksai J Kumar A Rugonfalvi S Nutt C Oneill O Seasman C Dempsey G Scott Cj Ellis He Mckechnie S Hutton Pj Di Tomasso Nn Vitale Mn Griffin Ro Dean Mn Cranshaw Jh Willett El Ioannou N Gillis S Csabi P Macfadyen R Dawson H Preez Pd Williams Aj Boyd O De Gordoa Lo Bramall J Symmonds S Chau Sk Wenham T Szakmany T Toth-tarsoly P Mccalman Kh Alexander P Stephenson L Collyer T Chapman R Cooper R Allan Rm Sim M Wrathall Dw Irvine Da Zantua Ks Adams Jc Burtenshaw Aj Sellors Gp Welters Id Williams Ke Hessell Rj Oldroyd Mg Battle Ce Pillai S Kajtor I Sivashanmugavel M Okane Sc Donnelly A Frigyik Ad Careless Jp May Mm Stewart R John Trinder T Hagan Sj Wise Mp Cole Jm Macfie Cc Dowling At Hurtado J Nin N Hurtado J Nuñez E Pittini G Rodriguez R Imperio Mc Santos C França Ag Ebeid A Deicas A Serra C Uppalapati A Kamel G Banner-goodspeed Vm Beitler Jr Mukkera Sr Kulkarni S Lee J Mesar T Shinn Iii Jo Gomaa D Tainter C Lee J Mesar T Lee J Yeatts Dj Warren J Lanspa Mj Miller Rr Grissom Ck Brown Sm Bauer Pr Gosselin Rj Kitch Bt Cohen Je Beegle Sh Gueret Rm Tulaimat A Choudry S Stigler W Batra H Huff Ng Lamb Kd Oetting Tw Mohr Nm Judy C Saito S Kheir Fm Kheir F Schlichting Ab Delsing A Crouch Dr Elmasri M Crouch Dr Ismail D Dreyer Kr Blakeman Tc Dreyer Kr Gomaa D Baron Rm Grijalba Cq Hou Pc Seethala R Aisiku I Henderson G Frendl G Hou Sk Owens Rl Schomer A Bumbasirevic V Jovanovic B Surbatovic M Veljovic M.

subject

Adult Male Diabetes mellitu LUNG SAFE Organ Dysfunction Scores humanos lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4]Socio-culturale Organ Dysfunction Score Diabetes Complications Diabetes mellitus puntuaciones de disfunción orgánica Risk Factors Diabetes Complication estudios prospectivos Humans factores de riesgo Prospective Studies Hospital Mortality Hypoxia mediana edad Acute hypoxemic respiratory failure Aged Respiratory Distress Syndrome anciano Acute respiratory distress syndrome Research Respiration respiración Respiratory Distress Syndrome Adult lcsh:Medical emergencies. Critical care. Intensive care. First aid lcsh:RC86-88.9 Middle Aged Respiration Artificial insuficiencia respiratoria Acute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFE Prospective Studie Artificial Acute hypoxemic respiratory failure; Acute respiratory distress syndrome; Diabetes mellitus; LUNG SAFE; Aged; Diabetes Complications; Diabetes Mellitus; Female; Hospital Mortality; Humans; Hypoxia; Male; Middle Aged; Organ Dysfunction Scores; Prospective Studies; Respiration Artificial; Respiratory Distress Syndrome Adult; Respiratory Insufficiency; Risk Factors Female Respiratory Insufficiency mortalidad hospitalaria complicaciones de la diabetes Human

description

Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF fully explained by cardiac failure were excluded. Important clinical characteristics were included in a stepwise selection approach (forward and backward selection combined with a significance level of 0.05) to identify a set of independent variables associated with having ARDS at any time, developing ARDS (defined as ARDS occurring after day 2 from meeting AHRF criteria) and with hospital mortality. Furthermore, propensity score analysis was undertaken to account for the differences in baseline characteristics between patients with and without diabetes mellitus, and the association between diabetes mellitus and outcomes of interest was assessed on matched samples. Results: Of the 4107 patients with AHRF included in this study, 3022 (73.6%) patients fulfilled ARDS criteria at admission or developed ARDS during their ICU stay. Diabetes mellitus was a pre-existing co-morbidity in 913 patients (22.2% of patients with AHRF). In multivariable analysis, there was no association between diabetes mellitus and having ARDS (OR 0.93 (0.78-1.11); p = 0.39), developing ARDS late (OR 0.79 (0.54-1.15); p = 0.22), or hospital mortality in patients with ARDS (1.15 (0.93-1.42); p = 0.19). In a matched sample of patients, there was no association between diabetes mellitus and outcomes of interest. Conclusions: In a large, global observational study of patients with AHRF, no association was found between diabetes mellitus and having ARDS, developing ARDS, or outcomes from ARDS.

year	journal	country	edition	language
2018-01-01

10.1186/s13054-018-2158-y https://doi.org/10.1186/s13054-018-2158-y