0000000000394978
AUTHOR
Liu J
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity
The pubertal height growth spurt is a distinctive feature of childhood growth reflecting both the central onset of puberty and local growth factors. Although little is known about the underlying genetics, growth variability during puberty correlates with adult risks for hormone-dependent cancer and adverse cardiometabolic health. The only gene so far associated with pubertal height growth, LIN28B, pleiotropically influences childhood growth, puberty and cancer progression, pointing to shared underlying mechanisms. To discover genetic loci influencing pubertal height and growth and to place them in context of overall growth and maturation, we performed genome-wide association meta-analyses i…
Epidemiology and patterns of tracheostomy practice in patients with acute respiratory distress syndrome in ICUs across 50 countries
Background: To better understand the epidemiology and patterns of tracheostomy practice for patients with acute respiratory distress syndrome (ARDS), we investigated the current usage of tracheostomy in patients with ARDS recruited into the Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure (LUNG-SAFE) study. Methods: This is a secondary analysis of LUNG-SAFE, an international, multicenter, prospective cohort study of patients receiving invasive or noninvasive ventilation in 50 countries spanning 5 continents. The study was carried out over 4 weeks consecutively in the winter of 2014, and 459 ICUs participated. We evaluated the clinical characteris…
Spontaneous Breathing in Early Acute Respiratory Distress Syndrome
Supplemental Digital Content is available in the text.
The ARGO-YBJ Experiment Progresses and Future Extension
Gamma ray source detection above 30 TeV is an encouraging approach for finding galactic cosmic ray origins. All sky survey for gamma ray sources using wide field of view detector is essential for population accumulation for various types of sources above 100 GeV. To target the goals, the ARGO-YBJ experiment has been established. Significant progresses have been made in the experiment. A large air shower detector array in an area of 1 km2 is proposed to boost the sensitivity. Hybrid detections with multi-techniques will allow a good discrimination between different types of primary particles, including photons and protons, thus enable an energy spectrum measurement for individual species. F…
Identifying associations between diabetes and acute respiratory distress syndrome in patients with acute hypoxemic respiratory failure: an analysis of the LUNG SAFE database
Background: Diabetes mellitus is a common co-existing disease in the critically ill. Diabetes mellitus may reduce the risk of acute respiratory distress syndrome (ARDS), but data from previous studies are conflicting. The objective of this study was to evaluate associations between pre-existing diabetes mellitus and ARDS in critically ill patients with acute hypoxemic respiratory failure (AHRF). Methods: An ancillary analysis of a global, multi-centre prospective observational study (LUNG SAFE) was undertaken. LUNG SAFE evaluated all patients admitted to an intensive care unit (ICU) over a 4-week period, that required mechanical ventilation and met AHRF criteria. Patients who had their AHRF…
Noninvasive Ventilation of Patients with Acute Respiratory Distress Syndrome: Insights from the LUNG SAFE Study
Rationale: Noninvasive ventilation (NIV) is increasingly used in patients with acute respiratory distress syndrome (ARDS). The evidence supporting NIV use in patients with ARDS remains relatively sparse.Objectives: To determine whether, during NIV, the categorization of ARDS severity based on the PaO2/FiO2 Berlin criteria is useful.Methods: The LUNG SAFE (Large Observational Study to Understand the Global Impact of Severe Acute Respiratory Failure) study described the management of patients with ARDS. This substudy examines the current practice of NIV use in ARDS, the utility of the PaO2/FiO2 ratio in classifying patients receiving NIV, and the impact of NIV on outcome.Measurements and Main…
Background radioactivity in the scaler mode technique of the Argo-YBJ detector
""ARGO-YBJ is an extensive air shower detector located at the Yangbajing Cosmic Ray Laboratory (4300 ma.s.l., 606 g cm^−2 atmospheric depth, Tibet, China).. It is made by a single layer of Resistive Plate Chambers. (RPCs, total surface ~ 6700 m^2) grouped into 153 units. called “clusters”. The low energy threshold of the experiment is obtained using the ”scaler operation mode”, counting all the particles hitting the detector without reconstruction of the shower size and arrival direction. For each cluster the signals generated by these particles are put in coincidence in a narrow time window (150 ns) and read by four independent. scaler channels, giving the counting rates of channel. >= 1, …
Gamma ray sources observation with the ARGO-YBJ detector
In this paper we report on the observations of TeV gamma ray sources performed by the air shower de- tector ARGO-YBJ. The objects studied in this work are the blazar Markarian 421 and the extended galactic source MGROJ1908+06, monitored during 2 years of operation. Mrk421 has been detected by ARGO-YBJ with a statisti- cal significance of 11 standard deviations. The observed TeV emission was highly variable, showing large enhance- ments of the flux during active periods. The study of the spectral behaviour during flares revealed a positive correla- tion of the hardness with the flux, as already reported in the past by the Whipple telescope, suggesting that this is a long term property of the…