Search results for "Solid"
showing 10 items of 3575 documents
Definitions for response and progression in ovarian cancer clinical trials incorporating RECIST 1.1 and CA 125 agreed by the Gynecological Cancer Int…
2011
The Gynecological Cancer Intergroup (GCIG) has previously reached consensus regarding the criteria that should be used in clinical trial protocols to define progression-free survival after first-line therapy as well as the criteria to define response to treatment in recurrent disease using the serum marker CA 125 and has specified the situations where these criteria should be used. However, the publications did not include detailed definitions, nor were they written to accommodate the new version of Response Evaluation Criteria In Solid Tumors (RECIST) criteria (version 1.1) now available. Thus, we recommend that the definitions described later in detail are incorporated into clinical trial…
Periodontitis as a risk factor for head and neck cancer
2020
Background Periodontitis may be associated with the development of head and neck cancer (HNC). A literature review was conducted to understand the possible association between them. Material and Methods Articles published in the PubMed database from January 1999 and May 2020 were retrieved. Limitations of the studies and biological mechanisms were discussed. Results A total of 4,232 articles were found. Of these, 13 were analyzed according to inclusion criteria. Most papers found some association between periodontitis and HNC, although differences in periodontal evaluation, sample size, study design and tumor sites were observed. Porphyromonas gingivalis appears to increase the chance of bo…
Updated results of the PARP1/2 inhibitor pamiparib in combination with low-dose (ld) temozolomide (TMZ) in patients (pts) with locally advanced or me…
2019
Post-transplant consolidation based on combination of lenalidomide and proteasome inhibitors in multiple myeloma
2021
Multiple myeloma (MM) is a hematological malignancy due to uncontrolled proliferation of neoplastic plasma cells in the bone marrow, associated to chromosomal instability and cytogenetic abnormalities, which could have an impact on prognosis. Response to treatment and survival of newly diagnosed myeloma patients is heterogeneous, with median overall survival ranging from two to more than ten years, due to clinical and biological factors. To warrant long-term control of disease, several strategies have been proposed in the last years, including short-term high-dose of treatment, named as consolidation, before maintenance. This review will discuss the role of consolidation in the current myel…
Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Fourth Meeting
2013
The Fourth Expert Meeting of the Mesenchymal Stem Cells in Solid Organ Transplantation (MiSOT) Consortium took place in Barcelona on October 19 and 20, 2012. This meeting focused on the translation of preclinical data into early clinical settings. This position paper highlights the main topics explored on the safety and efficacy of mesenchymal stem cells as a therapeutic agent in solid organ transplantation and emphasizes the issues (proper timing, concomitant immunossupression, source and immunogenicity of mesenchymal stem cells, and oncogenicity) that have been addressed and will be followed up by the MiSOT Consortium in future studies.
Intratumoral PO2 Histography as Predictive Assay in Advanced Cancer of the Uterine Cervix
1994
Experimental evidence suggests that the hypoxic fraction in a solid tumor may increase its malignant potential and reduce its sensitivity towards nonsurgical treatment modalities such as standard irradiation and certain anticancer agents1–5. However, the clinical importance of tumor hypoxia remains uncertain since valid methods for the routine measurement of intratumoral O2-tensions in patients have so far been lacking.
Online Tourism System Development for Searching and Planning Trips with User’s Requirements
2020
The aim of the work is to simplify the process of finding and planning travels for users through the use of the intellectual system of integration and content creation. Information sources that comprehensively describe the concept of tourist information resources are considered. An overview and comparison of certain indicators of existing tourism information and service provider services that can be considered conceptually identical to the system being developed are carried out. The existing data integration technologies were identified and analyzed, their advantages and disadvantages were examined, and the feasibility of using each of the technologies in the developed system is considered.…
ONG internacionales y solidaridad global. Un análisis referido a la sociedad española (International NGOs and Global Solidarity. A Focus on Spanish S…
2007
Several analysts have pointed out the emergence of a global consciousness that is closely related to the process of globalization of social life. It has been dered that this global consciousness, which is supported on an expansion of the geographical space of responsibility from which citizens feel they are being begged for aid, is encouraged by the rev lution of information and communication technologies (ICT), the contents broadcast by the mass media and the action of international NGOs. From the context of these and starting from the data c ntained in a CIS survey (E-2419), this paper seeks to contrast empirically the hypothesis of the modifying action of the «cultural reference framewor…
Mechanical behavior and limits to the microhardness testing of hard multilayer coatings on soft substrates
2000
Multilayer coatings of (Ti, Al) N x , (Ti, C)N x and (Nb, C)N x with bilayer thickness of 0.8-8 nm have been deposited by reactive sputtering on stainless steel substrates. Vickers microhardness measurements in the load range of 3.10 -3 to 1 N were performed using a self-adjusting tester. It has been shown that in order to obtain the true hardness of multilayer coatings on a softer substrate, the indentation depth should not exceed about 10% of the coating thickness. Indentation criteria for polycrystalline, amorphous and nanostructured multilayer coatings are compared. The obtained criterion for multilayer coatings is close to that for amorphous films.
Diode-pumped bulk Er:Yb:Glass 1.54μm pulsed laser with 1.2J output and 25% optical efficiency
2002
We report a pulsed transversely diode-pumped compact Er:Yb:Glass laser of uncomplicated design, delivering output energy of approx. 1.2J in free-running operation and 25% optical slope efficiency.