Search results for "T1"
showing 10 items of 587 documents
Territorio y creación de empresas de economía social: Estudio a nivel de las Comunidades Autónomas de España
2016
En el contexto de destruccion de empleo y empresas de todos los tamanos y ti-pos, surge el debate sobre la posible existencia de un patron geografico en el surgimiento de nuevas empresas. En dicho contexto, las empresas de economia social resurgen como una alternativa de organizacion de la actividad economica mas eficaz y eficiente socialmente.Este trabajo analiza comparativamente —formas tradicionales versus empresas de economia social— la evolucion territorial en ese surgimiento de empresas, en lo que podria denominarse clusters de empresas de economia social. Se emplearon tecnicas de econo-metria espacial. La muestra la conforman las empresas creadas en Espana entre 2001–2013.Los resulta…
Pacted transition to democracy : The case of Mozambique
2016
The findings of “third wave” studies on democratic transitions in Southern Europe and Latin America from the 1970s suggested that a democratic outcome is most likely when contending parties are relatively equal and elites make a pact to navigate the transition process. However, later studies of post-communist transitions do not support this inference. This paper analyses the transition process in Mozambique, a former “Afro-communist” regime, during the early 1990s. The findings show that – contrary to the conclusions drawn from the “third wave” studies – in Mozambique the pact concluded in the context of the peace accord of 1992, which ended a sixteenyear civil war, had contradictory result…
Antônio Etíope e Benedito, o mouro: o escravinho Santo e o preto eremita
2009
This article discusses the process of canonization of two African slaves, Benedict and Anthony, who were taken to Sicily through a combination of privacy wars, the slave trade and conflicts between Christian states and the Ottoman Empire in the context of modern-era Mediterranean. Along with other "servants of God" with exemplary lives, they both joined the Franciscan Order and were elevated to the altar after their deaths, while enslaved Christians in African territory "took the turban" with some even became local Muslim authorities. Sicily, a Spanish vice-kingdom near the northern African coast, was a cultural crossroad and for at the same time a privileged laboratory for the activity of …
Genome-Wide Inhibition of Pro-atherogenic Gene Expression by Multi-STAT Targeting Compounds as a Novel Treatment Strategy of CVDs.
2018
Cardiovascular diseases (CVDs), including atherosclerosis, are globally the leading cause of death. Key factors contributing to onset and progression of atherosclerosis include the pro-inflammatory cytokines Interferon (IFN)a and IFN? and the Pattern Recognition Receptor (PRR) Toll-like receptor 4 (TLR4). Together, they trigger activation of Signal Transducer and Activator of Transcription (STAT)s. Searches for compounds targeting the pTyr-SH2 interaction area of STAT3, yielded many small molecules, including STATTIC and STX-0119. However, many of these inhibitors do not seem STAT3-specific. We hypothesized that multi-STAT-inhibitors that simultaneously block STAT1, STAT2, and STAT3 activit…
A multicenter phase 1 study of solitomab (MT110, AMG 110), a bispecific EpCAM/CD3 T-cell engager (BiTE®) antibody construct, in patients with refract…
2018
ABSTRACT We assessed the tolerability and antitumor activity of solitomab, a bispecific T-cell engager (BiTE®) antibody construct targeting epithelial cell adhesion molecule (EpCAM). Patients with relapsed/refractory solid tumors not amenable to standard therapy received solitomab as continuous IV infusion in a phase 1 dose-escalation study with six different dosing schedules. The primary endpoint was frequency and severity of adverse events (AEs). Secondary endpoints included pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity. Sixty-five patients received solitomab at doses between 1 and 96 µg/day for ≥28 days. Fifteen patients had dose-limiting toxicities (DLTs): e…
EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.
2015
KRAS mutational status is considered a negative predictive marker of the response to anti-EGFR therapies in colorectal cancer (CRC) patients. However, conflicting data exist regarding the variable response to EGFR-targeted therapy. The effects of oncogenic KRAS on downstream targets were studied in cell lines with different KRAS mutations. Cells harboring a single KRASG13D allele showed the most tumorigenic profile, with constitutive activation of the downstream pathway, rendering them EGF-unresponsive. Conversely, KRASA146T cells showed a full EGF-response in terms of signal transduction pathways, cell proliferation, migration or adhesion. Moreover, the global acetylome of CRC cells was al…
El Discurso del profesorado de educación musical en la innovación educativa con tic: posicionamientos en la evaluación del software tactus.
2014
This paper presents teachers positioning analysis around the assessment of ad hoc software designed for learning musical rhythm called “Tactus”. The main objective is to study the teachers speeches and opinions in software assessment, which is built through the speeches analysis (n = 115) in 8 focus groups, with a descriptive model of 5 clusters. The study gives us a diverse, varied and a full picture in educational software evaluation trough teachers’ discourses analysis. En este estudio empírico analizamos los discursos y posicionamientos del profesorado en torno a la evaluación de un software diseñado ad hoc, para el aprendizaje del ritmo musical denominado Tactus. El objetivo de investi…
Diseño y Evaluación de un programa informático para la educación musical de maestros no especialistas. El caso de EMOLAB.
2016
This article shows the design, development and evaluation of a software for teaching support in a music training course for pre-service non music teachers. The aim of EMOLab has been addressing to both production and perception musical activities. The assessment of software was done by freshmen enrolled in Elementary Education Teacher Training degree. They completed a questionnaire that collected their opinions (versatility, efficiency, ease of use, quality of graphical environment, adequacy, interest, facilitating learning, feedback, functionality) and perceptions on more general aspects (control, guidance, affection, consultation, verification, tracing). The data suggest that students per…
Performing sound of the past: Remix in electronic dance music culture
2014
The term remix, defined as an activity of taking data from pre-existing materials to combine them into new forms according to personal taste, relates to various elements and areas of contemporary culture. Whichever model used, consideration of the remix depends on recognition of pre-existing cultural codes. Therefore, as a second layer, the remix relies on the authority of the original and it functions at the meta-level. The audience may see a trace of history with the pre-existing object and the meaning creates in the viewer(s), reader(s), listener(s) or, in the contemporary world of DJs and popular electronic dance music culture - in dancer(s). With the aim of specifying modes of creating…
La zarzuela en el área mediterránea
1996
En este trabajo se estudia la vida y creación zarzuelística en el área mediterránea, tomando un área geográfica que abarca la Comunidad Valenciana y la región de Murcia. Dentro de esta ubicación se dedica una atención especial a la ciudad de Valencia, como importante centro de actividad musical. Cronológicamente, los límites son el comienzo del siglo XIX por un lado, y el inicio de la Guerra Civil Española por otro. A su vez, el ámbito temporal abarcado aparece dividido en tres periodos que coinciden con la evolución del género zarzuelístico. En cada etapa se comentan aspectos como los locales teatrales, el repertorio y el reflejo de la zarzuela en la sociedad de la época. En este último ap…