Search results for "TERT"

Toxic megacolon and human Cytomegalovirus in a series of severe ulcerative colitis patients

2015

Abstract Background Human Cytomegalovirus (HCMV) infection has been reported to be a cause of refractory ulcerative colitis (UC). Toxic megacolon (TM) is a rare but severe complication of an acute attack of UC. Objectives Aim of this study is to evaluate in a case-control study the association between HCMV and TM. Study design All patients who were admitted at Medicine Department of V. Cervello Hospital in Palermo (tertiary referral center) for a severe UC flare-up complicated by the onset of TM (diameter of the transverse colon > 6 cm) between January 1990 and November 2011 were identified through the electronic database. A total of 24 consecutive patients (16 male/8 female) with TM were i…

Baltic Journal of English Language, Literature and Culture, N 6

2016

On the lookout for the infinite variations of chaos : approaching the work of Rodrigo Fresán

2014

The aim of this thesis is to examine and interpret the sophisticated composition of Rodrigo Fresán’s “house of books” or “intertextual series”. Our research will demonstrate that the nine books of the Argentinean writer, in spite of their different generic classifications and their significant thematic diversity, form a coherent whole and they cannot be therefore analyzed separately. The continuity, the logic and, most importantly, the systematic nature of this literary project, that unites all the books of the author in an original and fractal intertextual series “in progress”, will be showed. Considering the fact that this work is characterized by a generic hybridity and a tension between…

Novel Multifunctional Polymeric Photoinitiators and Photo-Coinitiators Derived from Hyperbranched Polyglycerol

2007

A new class of hyperbranched PPIs and PPCs have been prepared. The introduction of compatibilizing groups such as MEEA or trimethylacetate enhanced their solubility in radiation-curable formulations and led to an improved photoactivity compared with the corresponding MPI and MPC. Although the molecular weights of the subject PPIs and PPCs exceeded 800 g mol -1 , the viscosities of the radiation-curable formulations were still suitable for inkjet application. The combination of high photoactivity, low viscosity, and low extract-ability after curing rendered the resulting hyperbranched PPIs and PPCs attractive as components in the inkjet ink for inkjet printing, e.g., in food packaging.

Forecasting Molecular Features in IDH-Wildtype Gliomas: The State of the Art of Radiomics Applied to Neurosurgery

2023

Simple Summary The prognostic expectancies of patients affected by glioblastoma have remained almost unchanged during the last thirty years. Along with specific oncological research and surgical technical alternatives, corollary disciplines are requested to provide their contributions to improve patient management and outcomes. Technological improvements in radiology have led to the development of radiomics, a new discipline able to detect tumoral phenotypical features through the extraction and analysis of a large amount of data. Intuitively, the early foreseeing of glioma features may constitute a tremendous contribution to the management of patients. The present manuscript analyzes the p…

Nouvelles perspectives concernant la structure et la fonction du domaine carboxyl terminal de Hfq

2015

Accumulating evidence indicates that RNA metabolism components assemble into supramolecular cellular structures to mediate functional compartmentalization within the cytoplasmic membrane of the bacterial cell. This cellular compartmentalization could play important roles in the processes of RNA degradation and maturation. These components include Hfq, the RNA chaperone protein, which is involved in the post-transcriptional control of protein synthesis mainly by the virtue of its interactions with several small regulatory ncRNAs (sRNA). The Escherichia coli Hfq is structurally organized into two domains. An N-terminal domain that folds as strongly bent β-sheets within individual protomers to…

Micropollutants removal in an anaerobic membrane bioreactor and in an aerobic conventional treatment plant

2012

The paper expresses an attempt to tackle the problem due to the presence of micropollutants in wastewater which may be able to disrupt the endocrine system of some organisms. These kinds of compounds are ubiquitously present in municipal wastewater treatment plant (WWTP) effluents. The aim of this paper is to compare the fate of the alkylphenols-APs (4-(tert-octyl)) phenol, t-nonylphenol and 4-p-nonylphenol and the hormones (estrone, 17ß-estradiol and 17¿-ethinylestradiol) in a submerged anaerobic membrane bioreactor (SAMBR) pilot plant and in a conventional activated sludge wastewater treatment plant (CTP). The obtained results are also compared with the results obtained in a previous stud…

Intertekstualitāte personālvadības rakstveida žanros

2018

Intertekstualitāte nav jauna ideja, bet pirmo intertekstualitātes pētījumu veica Kristeva, viņas pētījumi galvenokārt ir saistīti ar intertekstualitātes izpēti literatūrā. Pēc tam daudzi autori analizēja intertekstuālitāte valodniecības un diskursa ietvaros. Tomēr intertekstualitāte uzņēmējdarbības jomā joprojām ir relatīvi neizpētīts, jo īpaši personālvaldības rakstveida žanros. Personālvaldības sfēra ietver savstarpēji saistītu dokumentu tīklu kas atspoguļo profesionālo praksi, tāpēc ir svarīgi izpētīt, kuras intertekstualās atsauces tiek minētas visbiežāk. Tādēļ pašreizējais darbs ir vērsts uz to, lai identificētu un analizētu interteksta attiecības personālvaldības rakstveida žanros. An…

Inhibition of the Cysteine Protease Human Cathepsin L by Triazine Nitriles: Amide⋅⋅⋅Heteroarene π-Stacking Interactions and Chalcogen Bonding in the …

2016

We report an extensive "heteroarene scan" of triazine nitrile ligands of the cysteine protease human cathepsin L (hCatL) to investigate π-stacking on the peptide amide bond Gly67-Gly68 at the entrance of the S3 pocket. This heteroarene⋅⋅⋅peptide bond stacking was supported by a co-crystal structure of an imidazopyridine ligand with hCatL. Inhibitory constants (Ki ) are strongly influenced by the diverse nature of the heterocycles and specific interactions with the local environment of the S3 pocket. Binding affinities vary by three orders of magnitude. All heteroaromatic ligands feature enhanced binding by comparison with hydrocarbon analogues. Predicted energetic contributions from the ori…

AML-associated Flt3 kinase domain mutations show signal transduction differences compared with Flt3 ITD mutations

2005

Activating mutations of Flt3 are found in approximately one third of patients with acute myeloid leukemia (AML) and are an attractive drug target. Two classes of Flt3 mutations occur: internal tandem duplications (ITDs) in the juxtamembrane and point mutations in the tyrosine kinase domain (TKD). We and others have shown that Flt3-ITD induced aberrant signaling including strong activation of signal transducer and activator of transcription 5 (STAT5) and repression of CCAAT/estradiol-binding protein α (c/EBPα) and Pu.1. Here, we compared the signaling properties of Flt3-ITD versus Flt3-TKD in myeloid progenitor cells. We demonstrate that Flt3-TKD mutations induced autonomous growth of 32D ce…