Search results for "THD"
showing 10 items of 129 documents
Experimental Evaluation of Dead-Time Impacts on the Efficiency and THD for a Three-Phase Five-Level Cascaded H-Bridge Inverter
2022
Cascaded H-Bridges Multilevel Inverter (CHBMI) is a fascinating solution for optimization purposes in several application fields. The CHBMI performance optimization can be reached both with hardware and software solutions. In detail, the CHBMI performances are a function of the modulation strategy adopted and its parameters such as modulation index, switching frequency, and dead time. This paper presents performance experimental analysis on dead time effects on CHBMI performance in terms of harmonic distortion and conversion efficiency. In this analysis, two different modulation strategies have been considered and implemented. The paper focuses on modulation strategies implemented, the test…
Effect of electron-withdrawing substituents on the electrophilicity of carbonyl carbons
2005
Indexación: Scopus The substituent effects on the carbonyl carbon atom for a series of twelve substituted phenyl acetates have been rationalized using a global electrophilicity index. This index is linearly correlated with the experimental reaction rate coefficients. We found that, in contrast to the proposed interpretation based on experimental 13C NMR chemical shifts and ground state destabilization calculations, the electrophilicity of carbonyl compounds increases due to the effect promoted by electron-withdrawing groups in these systems. https://www.sciencedirect.com/science/article/pii/S0040402004018046?via%3Dihub
Nationwide evaluation of day-to-day clinical pharmacists' interventions in German hospitals.
2015
tudy Objective To describe and evaluate the extent and diversity of nationwide data from clinical pharmacists’ interventions (PIs) in German hospitals. Design Retrospective analysis. Data Source The ADKA-DokuPIK German database, a national anonymous self-reported Internet-based documentation system for routine PIs as well as for medication errors reported by German hospital pharmacists. Measurements and Main Results Data sets from ADKA-DokuPIK entered between January 2009 and December 2012 were analyzed descriptively. A total of 27,610 PIs were entered, mainly by ward-based clinical pharmacists (82.5%). Most of the PIs were performed on surgical wards (37.8%), followed by anesthesiology/int…
Preclinical evidence of new opioid modulators for the treatment of addiction.
2010
Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing…
Mpdz is a quantitative trait gene for drug withdrawal seizures
2004
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate.
2007
Hemicrania continua (HC) is an uncommon and under-recognized primary headache disorder characterized by a strictly unilateral continuous headache of moderate intensity with possible exacerbations and associated with ipsilateral autonomic features. HC has generally a prompt and enduring response to indomethacin although 25% to 50% of treated patients develop gastrointestinal side effects. These cases pose a difficult management challenge as no other drug is consistently effective in HC. Recently 2 HC patients responsive to topiramate treatment have been reported. Here we describe 2 more patients effectively treated with topiramate. Neither reported any side effects and one had persisting res…
Adverse drug reactions in the oral cavity
2012
Several drugs may have a number of adverse reactions (ADRs) involving the oro-facial region. The dose of the drug and the time required for the reaction to take place are relevant parameters; nonetheless, ADRs mechanisms are not always known and ADRs are not always predictable since aspects other than drug pharmacodynamics and/or pharmacokinetics, as well as various interacting variables contribute to the final outcome. All tissues and many functions of the oral cavity can be affected. In particular, salivary function is fre- quently involved and hypo-salivation is the main manifestation; several mucosal lesions with different morphology (ulcerations, vesiculo- bullous lesions, white lesion…
Changing Trends in Drug Prescription and Causes of Treatment Discontinuation of First Biologic Over Ten Years in Psoriasis in the Spanish Biobadaderm…
2020
Background and objectives: Current psoriasis guidelines do not usually include recommendations about first line classical or biologic treatment. The objectives of this study were: to describe shifts in the prescription of the first biological treatment, and to compare treatment withdrawal and rates of adverse events over ten years. Material and methods: Biobadaderm registry was analyzed to describe: first biological prescription in bio-naive patients, adverse events rate and reasons for drug withdrawal comparing three periods of time (2008-2010, 2011-2014, 2015-2018). Results: Anti-TNF drugs were the most prescribed biological drug from 2008 to 2010. Ustekinumab has become the most prescrib…
Drug-Induced Respiratory Disease in Connective Tissue Diseases
2004
Publisher Summary This chapter discusses drug-induced respiratory disease in connective tissue diseases. Drug-induced lung diseases (DILDs) vary in severity from mild to life threatening. Generally, DILDs subside upon drug discontinuance, and leave permanent sequelae in a minority of patients. Less frequently, DILDs persist unabated, or progress despite drug withdrawal, requiring specific management. Drugs used in connective tissue diseases (CTDs) can produce a constellation of pulmonary and systemic reactions. These can mimic pulmonary involvement from CTD, a systemic disease, or an infection, and are difficult to prevent, predict, and diagnose. Maintaining a high index of suspicion enable…
Lielbritānijas izstāšanās no Eiropas Savienības un tā ietekme uz Latvijas Republikas valstspiederīgajiem
2020
Bakalaura darbs “Lielbritānijas izstāšanās no Eiropas Savienības un tā ietekme uz Latvijas Republikas valstspiederīgajiem” ir pētījums par līdz šim nebijušu gadījumu, kad kāda no ES dalībvalstīm vēlas izstāties no ES. Bakalaura darba mērķis ir izpētīt arī analīzēt tiesiskās attiecības starp ES un Lielbritāniju, kas radušās sakarā ar ES dalībvalsts – Lielbritānijas izstāšanos no ES un tās ietekmi uz Latvijas Republikas valstspiederīgajiem. Darba uzdevumi: 1.Apzināt vēsturisko situāciju un Lielbritānijas izstāšanās ES norises tiesisko procedūru; 2.Veikt analīzi par pārejas perioda tiesisko regulējumu un tiesību aktiem, kuri būtu jāpieņem pārejas laikā; 3.Apskatīt tiesisko vīziju Lielbritānija…