Search results for "TP"
showing 10 items of 4688 documents
"Ikke alle piloter flyr" : implementering av telemedisin i norske kommuner
2019
Masteroppgave helse- og sosialinformatikk HSI500 - Universitetet i Agder 2019 Running pilots is a widespread way of conducting innovations in the Norwegian health service, many of these projects are not implemented permanently or lead to lasting changes in services. Solutions based on Telemedicine are being tested, but the implementation rate does not match the existing ambitions. The aim of this study is to gain increased knowledge of some of the factors that are required for pilot projects in Telemedicine to go from pilots to permanent solutions, especially focused on stakeholders and their role. The thesis question is «What is the significance of different stakeholders in the municipalit…
Cardiolipin content controls mitochondrial coupling and energetic efficiency in muscle
2020
Decreasing mitochondrial energy-production efficiency in skeletal muscle can confer protection against diet-induced obesity.
Sense and Antisense DMPK RNA Foci Accumulate in DM1 Tissues during Development.
2015
International audience; Myotonic dystrophy type 1 (DM1) is caused by an unstable expanded CTG repeat located within the DMPK gene 3'UTR. The nature, severity and age at onset of DM1 symptoms are very variable in patients. Different forms of the disease are described, among which the congenital form (CDM) is the most severe. Molecular mechanisms of DM1 are well characterized for the adult form and involve accumulation of mutant DMPK RNA forming foci in the nucleus. These RNA foci sequester proteins from the MBNL family and deregulate CELF proteins. These proteins are involved in many cellular mechanisms such as alternative splicing, transcriptional, translational and post-translational regul…
Gastric emptying, small intestinal transit and fecal output in dystrophic (mdx) mice.
2009
Duchenne muscular dystrophy (DMD), which results from deficiency in dystrophin, a sarcolemma protein of skeletal, cardiac and smooth muscle, is characterized by progressive striated muscle degeneration, but various gastrointestinal clinical manifestations have been observed. The aim was to evaluate the possible impact of the dystrophin loss on the gastrointestinal propulsion in mdx mice (animal model for DMD). The gastric emptying of a carboxymethyl cellulose/phenol red dye non-nutrient meal was not significantly different at 20 min from gavaging between wild-type and mdx mice. The intestinal transit and the fecal output were significantly decreased in mdx versus normal animals, although th…
Load Distribution in the Lumbar Spine During Modeled Compression Depends on Lordosis.
2021
Excessive or incorrect loading of lumbar spinal structures is commonly assumed as one of the factors to accelerate degenerative processes, which may lead to lower back pain. Accordingly, the mechanics of the spine under medical conditions, such as scoliosis or spondylolisthesis, is well-investigated. Treatments via both conventional therapy and surgical methods alike aim at restoring a “healthy” (or at least pain-free) load distribution. Yet, surprisingly little is known about the inter-subject variability of load bearings within a “healthy” lumbar spine. Hence, we utilized computer tomography data from 28 trauma-room patients, whose lumbar spines showed no visible sign of degeneration, to …
Unusual manifestation of an osteoid osteoma of the capitate.
1999
A case of osteoid osteoma of the capitate in a 29-year-old male is reported. The patient suffered from unspecific clinical findings and a 3-year history of uncharacteristic wrist pain. Conventional radiographs of the wrist revealed a circumscribed sclerosis in the proximal part of the capitate bone beside a diffuse demineralisation of the carpal bones. Magnetic resonance imaging demonstrated a circumscribed, tumorous lesion with marked enhancement after IV administration of contrast agent and a highly calcified nidus, which was sharply demarcated by a small rim of granulation tissue from the surrounding spongious bone. Based on MRI findings, the diagnosis of an osteoid osteoma was establish…
Development of the first marmoset-specific DNA microarray (EUMAMA): a new genetic tool for large-scale expression profiling in a non-human primate
2007
Abstract Background The common marmoset monkey (Callithrix jacchus), a small non-endangered New World primate native to eastern Brazil, is becoming increasingly used as a non-human primate model in biomedical research, drug development and safety assessment. In contrast to the growing interest for the marmoset as an animal model, the molecular tools for genetic analysis are extremely limited. Results Here we report the development of the first marmoset-specific oligonucleotide microarray (EUMAMA) containing probe sets targeting 1541 different marmoset transcripts expressed in hippocampus. These 1541 transcripts represent a wide variety of different functional gene classes. Hybridisation of …
Speed-Related Energy Flow and Joint Function Change During Human Walking.
2021
During human walking, mechanical energy transfers between segments via joints. Joint mechanics of the human body are coordinated with each other to adapt to speed change. The aim of this study is to analyze the functional behaviors of major joints during walking, and how joints and segments alter walking speed during different periods (collision, rebound, preload, and push-off) of stance phase. In this study, gait experiment was performed with three different self-selected speeds. Mechanical works of joints and segments were determined with collected data. Joint function indices were calculated based on net joint work. The results show that the primary functional behaviors of joints would n…
La circulation des termes dans le discours médiatique : peut-on informer sans déformer ?
2016
Media diversification and information superhighways that have become faster and faster have boosted the circulation of economic terms in the popular press, along with the interaction between editorial contents targeted at the general population, which are similar in nature. This twin phenomenon of circulation and interaction was highlighted in a contrastive study of the way the German and the French press managed the euro crisis between 2011 and 2013: articles devoted to the debt of countries that are going through hard economic times require expert knowledge, but also resort to popularization strategies that show multi-level interdiscursivity.
Mazākumtautību skolēnu lasītprasmes un vārdu krājuma attīstīšana latviešu valodas stundās
2022
Pētāmā problēma “Didaktiskās iespējas lasītprasmes attīstībai 1. klašu skolēniem latviešu valodas stundās” ir aktuāla mūsdienās, jo lasītprasmes attīstīšana skolēniem noteikti ir viens no svarīgākajiem sākumskolas izglītības uzdevumiem. Kā pareizi norāda zinātnieki, spēja lasīt ir skolēna intelektuālās, emocionālās attīstības pamatā, veicina viņa kultūras skatījuma bagātināšanu. Prasme lasīt latviešu valodā - ir mazākumtautību skolēnu universāla prasme, jo tā ir pieprasīta citos mācību priekšmetos, kuri tiek vadīti bilingvāli vai latviešu valodā. Tas nozīmē, ka skolēna panākumi dažādu priekšmetu apguvē lielā mērā ir atkarīgi no tā, cik attīstītas ir viņa lasītprasmes gan dzimtajā valodā, ga…