Search results for "TPA"

Correction: DAPIT Over-Expression Modulates Glucose Metabolism and Cell Behaviour in HEK293T Cells

2015

Introduction Diabetes Associated Protein in Insulin-sensitive Tissues (DAPIT) is a subunit of mitochondrial ATP synthase and has also been found to associate with the vacuolar H+-ATPase. Its expression is particularly high in cells with elevated aerobic metabolism and in epithelial cells that actively transport nutrients and ions. Deletion of DAPIT is known to induce loss of mitochondrial ATP synthase but the effects of its over-expression are obscure. Results In order to study the consequences of high expression of DAPIT, we constructed a transgenic cell line that constitutively expressed DAPIT in human embryonal kidney cells, HEK293T. Enhanced DAPIT expression decreased mtDNA content and …

Variable mode of estrus affects female decision for multiple mating

2011

Investigating patterns of variation in mating strategies may shed light on their evolutionary importance as well as their impact on the strength and shape of sexual selection. Multimale mating (polyandry) and mate choice are intensely studied subjects in the area of sexual selection, but little is known about intraspecific patterns of variation that may respond to dynamic cost-benefit balances. In a laboratory study, we investigated the mating behavior of female bank voles (Myodes glareolus) with distinctly different time and energy budgets: They were either in cycling estrus (CE) or postpartum estrus (PPE) shortly after delivery. Postpartum mating is highly constrained by time and energy d…

Effect of a prenatal lifestyle intervention on physical activity level in late pregnancy and the first year postpartum

2017

Background: Despite documented health benefits for mother and baby, physical activity (PA)-level tends to decline in pregnancy. Overweight/obese and physically inactive women are two selected groups at increased risk of pregnancy complications. Thus, efficient strategies to maintain or increase PA-level in pregnancy and the postpartum period, especially among these women, are warranted. This secondary analysis examined the effect of a prenatal lifestyle-intervention on PA-level in late pregnancy and the first year postpartum, with subanalysis on initially physically active versus inactive and normal-weight versus overweight/obese women. Method: The Norwegian Fit for Delivery (NFFD) randomiz…

Molecular mechanisms involved in the regulation of stress response in Oenococcus oeni and experimental evolution

2020

Oenococcus oeni is the main bacterium responsible of malolactic fermentation in wine. This lactic acid bacteria grow in the stressful wine environment (high ethanol content, sulfites, low pH and low temperatures….). To maintain its cellular homeostasis, O. oeni has established mechanisms of resistance to its ecological niche. This research work focuses on the adaptative response of O. oeni to its environment and especially to acidity. Two approaches have been implemented (1) First, a targeted approach to characterize the molecular actors involved in regulating the general stress response. The RNA interference technique made possible the characterization of the repressor CtsR as well as two …

Recommendations for eye care during the alarm state by the coronavirus disease pandemic COVID-19.

2020

Abstract Objective Minimize exposure to the SARS-CoV-2, reduce the chances of cross-transmission between patients and healthcare personnel, and prevent the development of postoperative complications from the management of patients with eye diseases during the 2019 coronavirus disease pandemic (COVID-19). Methods COVID-19 literature review and consensus establishment between different Spanish ophthalmology societies in order to provide guidelines and recommendations of maximum resources primarily conditioned by the state of alert, confinement and social distancing that occurs in Spain since March 16, 2020. Results The recommendations will promote the adoption of action and protection measure…

Los espacios públicos de la cotidianeidad / 2

2006

Latvijas zvanu centru SIA Transcom Worldwide Latvia un SIA Sonido sociālā tīkla Facebook komunikācijas analīze 2021. gadā

2022

Bakalaura darba “Latvijas zvanu centru SIA Transcom Worldwide Latvia un SIA Sonido sociālā tīkla Facebook komunikācijas analīze 2021. gadā” mērķis ir izpētīt minēto uzņēmumu Facebook komunikāciju un sniegt tās vērtējumu. Mērķa īstenošanai tika izmantotas trīs pētījuma metodes - kontentanalīze, intervija un aptauja. Teorētiskajā daļā tika aplūkotas teorētiskās nostādnes, kā sociālo tīklu sabiedrība, sociālo tīklu komunikācija, sociālo tīklu komunikācijas stratēģijas, organizāciju ārējā komunikācija, zīmola tēls un sociālo tīklu auditorijas piesaistes metodes. Empīriskajā daļā tika noskaidrots, ka uzņēmumu nepieciešamie uzlabojumi komunikācijā, korelē ar publicētā satura kontentanalīzes datie…

Viltus ziņu apkarošanas risinājumi Baltijas valstīs

2020

Darba tēma ir viltus ziņu apkarošanas risinājumi Baltijas valstīs. Darba mērķis ir noskaidrot, kā Baltijas valstīs risina jautājumus, lai ierobežotu manipulāciju ar komunikāciju infrastruktūru, radot, izplatot un pastiprinot viltus ziņas.Darba teorētiskajā daļā tiek izpētītas un aprakstītas teorētiskās nostādnes par viltus ziņām, definējumu dažādību, interneta vides izmaiņām un apskatīti viltus ziņu veidi. Darba empīriskajā daļā- izpētīti un aprakstīti valsts kā aktiera izmantotie instrumenti viltus ziņu apkarošanai- normatīvie akti, u.c. risinājumi; analizēti dažādu ekspertu viedokļi par iespējamiem viltus ziņu risinājumiem, analizēti sociālo tīklu viltus ziņu apkarošanas rīki; izpētīti ES…

Mass spectral identification of the blocked N-terminal tryptic peptide of the ATPase inhibitor from beef heart mitochondria

1984

AbstractThe presence of a formyl blocking group at the N-terminus of the ATPase inhibitor has been identified and the partial sequence of the N-terminal peptide has been determined by fast atom bombardment and field desorption coupled to mass spectrometry. Minor discrepancies in amino acid sequence of the inhibitor between the present and published data [(1981) Proc. Natl. Acad. Sci. USA 78, 7403-7407] are reported and its relationships with other inhbitors are briefly discussed.

Isolation and characterization of Wnt pathway-related genes from Porifera.

2006

The Wnt signal acts by binding to Frizzled receptors, with the subsequent activation of two different signal transduction cascades, the canonical and the non-canonical Wnt pathways, involved in cell growth, differentiation, migration and fate. The canonical pathway functions through the translocation of beta-catenin to the nucleus and the activation of TCF/LEF transcription factors; it plays an important role in developmental patterning and cell fate decisions during embryogenesis. The non-canonical Wnt pathway is responsible for the planar cell polarity process in invertebrates, and for the convergent-extension movements during vertebrate gastrulation. The final effect of the non-canonical…