Search results for "TPA"
showing 10 items of 770 documents
Atšķirības insulta menedžmentā Somijā un Latvijā
2022
Insults ir pasaulē prominents nāves un invaliditātes cēlonis. Šī darba mērķis ir izpētīt insulta pārvaldības atšķirības starp divām ģeogrāfiski tuvām Eiropas valstīm – Somiju un Latviju. Neskatoties uz to, ka tās atrodas tuvu viena otrai un ievēro ļoti līdzīgas insulta pārvaldības vadlīnijas, pastāv atšķirības insulta iznākumā. Šis darbs apraksta insulta pārvaldības speciālistu viedokļus attiecīgajās valstīs, lai noteiktu atšķirības un līdzības insulta pārvaldībā starp Somiju un Latviju. Tika izmantotas kvalitatīvas izpētes metodes, lai iegūtu pilnīgu izpratni par insulta pārvaldības praksi attiecīgajās valstīs. Abās valstīs tika veiktas ekspertu intervijas, un tās tika izmantotas kā materi…
Effect of Hormones on Sucrose Uptake and on ATPase Activity of Citrus sinensis L. Osbeck Leaves
1994
Carbohydrate accumulation in young, fully expanded leaves of Citrus sinensis L. Osbeck is affected by the presence of the fruitlet on the shoot. Previous work gave evidence that gibberellins may be involved in this 'fruit effect'. In the present work we have studied the effect of gibberellic acid (GA3) on 14C-sucrose uptake by leaf discs and whether its action could be due to a modulation of the plasma membrane ATPase, which maintains the H+ gradient that drives H+/sucrose co-transport. The effect of GA3 on 14C-sucrose uptake depended on the osmolarity of the assay medium. At 300 mOsm a reduction in the uptake rate was observed. The inhibitory effect of the hormone disappeared after preincu…
Pump currents generated by the purified Na+K+-ATPase from kidney on black lipid membranes.
1985
The transport activity of purified Na+K+-ATPase was investigated by measuring the electrical pump current induced on black lipid membranes. Discs containing purified Na+K+-ATPase from pig kidney were attached to planar lipid bilayers in a sandwich-like structure. After the addition of only microM concentrations of an inactive photolabile ATP derivative [P3-1-(2-nitro)phenylethyladenosine 5'-triphosphate, caged ATP] ATP was released after illumination with u.v.-light, which led to a transient current in the system. The transient photoresponse indicates that the discs and the underlying membrane are capacitatively coupled. Stationary pump currents were obtained after the addition of the H+, N…
INTRODUCTION
2016
Discovering hidden recurring patterns in observable behavioral processes is an important issue frequently faced by numerous advanced students and researchers across many research areas, such as, for example, psychology, biology, sports, robotics, media, finance, and medicine. As generally, the many powerful methods included in statistical software packages were not developed for this kind of analysis, discovering such patterns has proven a particularly difficult task, due to a lack of (a) adequate formalized models of the kinds of patterns to look for, (b) corresponding detection algorithms, and (c) their implementation in available software. The research described in this book is based on …
Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).
2012
The Rap1-GTP interacting adapter protein (RIAM) is an important protein in Rap1-mediated integrin activation. By binding to both Rap1 GTPase and talin, RIAM recruits talin to the cell membrane, thus facilitating talin-dependent integrin activation. In this article, we studied the role of the RIAM Ras-association (RA) and pleckstrin-homology (PH) domains in the interaction with Rap1. We found that the RA domain was sufficient for GTP-dependent interaction with Rap1B, and the addition of the PH domain did not change the binding affinity. We also detected GTP-independent interaction of Rap1B with the N-terminus of RIAM. In addition, we found that the PH domain stabilized the RA domain both in …
MRI of tarantulas: morphological and perfusion imaging.
2005
This paper describes a study performed to evaluate the feasibility of using a 1.5-T whole-body magnetic resonance imaging (MRI) equipment, in combination with pharmacokinetic modeling, to obtain in vivo information about the morphology and perfusion of tarantulas (Eurypelma californicum). MRI was performed on three tarantulas using spin-echo sequences for morphological imaging and a rapid spoiled gradient-echo sequence for dynamic imaging during and after contrast medium (CM; Gd-DTPA) injection. Signal enhancement in dynamic measurements was evaluated with a pharmacokinetic two-compartment model. Spin-echo images showed morphological structures well. Dynamic images were of sufficient qualit…
Realitat virtualitzada: Educació literària en contextos tecnologitzats
2014
Aquest article presenta una recerca exploratòria sobre la percepció i l'aplicació metodològica de les TIC al servei de l'educació literària de dues professores de secundària en contextos escolars tecnologitzats. La primera aportació del treball és la creació d'un marc teòric que pretén vincular els estudis didàctico-literaris sobre innovació tecnològica amb l'estès model del TPACK (Technological Pedagogical Content Knowledge) sobre sabers i competències tecnològiques del professorat. Posteriorment, i un cop presentada la metodologia d'investigació, es mostra el treball d'interpretació de les dades observades sobre dos eixos fonamentals: d'una banda, l'alineament dels coneixements docents am…
Ras, Rap, and Rac Small GTP-binding Proteins Are Targets for Clostridium sordellii Lethal Toxin Glucosylation
1996
Lethal toxin (LT) from Clostridium sordellii is one of the high molecular mass clostridial cytotoxins. On cultured cells, it causes a rounding of cell bodies and a disruption of actin stress fibers. We demonstrate that LT is a glucosyltransferase that uses UDP-Glc as a cofactor to covalently modify 21-kDa proteins both in vitro and in vivo. LT glucosylates Ras, Rap, and Rac. In Ras, threonine at position 35 was identified as the target amino acid glucosylated by LT. Other related members of the Ras GTPase superfamily, including RhoA, Cdc42, and Rab6, were not modified by LT. Incubation of serum-starved Swiss 3T3 cells with LT prevents the epidermal growth factor-induced phosphorylation of m…
NG2 regulates directional migration of oligodendrocyte precursor cells via Rho GTPases and polarity complex proteins.
2013
The transmembrane proteoglycan NG2 is expressed by oligodendrocyte precursor cells (OPC), which migrate to axons during developmental myelination and remyelinate in the adult after migration to injured sites. Highly invasive glial tumors also express NG2. Despite the fact that NG2 has been implicated in control of OPC migration, its mode of action remains unknown. Here, we show in vitro and in vivo that NG2 controls migration of OPC through the regulation of cell polarity. In stab wounds in adult mice we show that NG2 controls orientation of OPC toward the wound. NG2 stimulates RhoA activity at the cell periphery via the MUPP1/Syx1 signaling pathway, which favors the bipolar shape of migrat…
Tiesību normu laika aspekti tiesiskā un demokrātiskā valstī
2015
Promocijas darbā „Tiesību normu laika aspekti tiesiskā un demokrātiskā valstī” ir izpētīts, kuros gadījumos likumdevējs ir tiesīgs pieņemt tiesību normas ar iedarbību uz pagātnē izveidotām tiesiskajām attiecībām. Izveidotu tiesisko attiecību ietekmēšana ir izvērtējama, balstoties uz tiesiskās paļāvības principu. Lai noskaidrotu, vai tiesiskās paļāvības princips ir aizskarts, ir jākonstatē, vai tiesību normām ir atpakaļejošs spēks laikā. Atšķirībā no sodu tiesībām, kur atpakaļejošs spēka identificēšana per se padara tiesību normas par prettiesiskām, citās tiesību nozarēs pēc atpakaļejoša spēka konstatēšanas vēl būtu jāizvērtē, vai sabiedrības interešu aizsardzība nav iespējama ar mazāku ieja…