Search results for "Termination"
showing 10 items of 780 documents
L'effet des soft-skills sur la rémunération des diplômés
2016
Net.doc, n°149, janvier 2016; Les soft-skills forment un ensemble de compétences qui se rapporteraient davantage à un savoir-être et moins à un savoir théorique, et dépendraient notamment de la capacité des individus à réagir avec les autres. Ce document propose une analyse de leur impact sur le marché du travail en France, en essayant de mesurer leur influence sur le salaire des diplômés. Les résultats montrent que les soft skills vont notamment influencer les plus hauts salaires, ce qui suggère leur importance pour les emplois les plus qualifiés.Les analyses ainsi que la construction des indicateurs sont issus d'une étude sur un échantillon de diplômés de master ayant répondu à l'enquête …
La formation continue favorise-t-elle l'augmentation du salaire ?
1999
International audience
EGFR signalling is required for Paracentrotus lividus endomesoderm specification
2008
The EGFR pathway is critical for cell fate specification throughout the development of several organisms. Here we identified in sea urchin an EGFR-related antigen maternally expressed and showing a dynamic pattern of localization during development. To investigate the role played by the EGFR in Paracentrotus lividus development we blocked its activity by using the EGFR kinase inhibitor AG1478. This treatment produces decrease of EGFR phosphorylation, and embryos with various defects especially in the endomesoderm territory until to obtain an animalized phenotype. These effects are rescued by the addition of TGF-alpha, an EGFR ligand. The role played by EGFR-like along the animal/vegetal axi…
Inhibitory activities of short linear motifs underlie Hox interactome specificity in vivo
2015
Hox proteins are well-established developmental regulators that coordinate cell fate and morphogenesis throughout embryogenesis. In contrast, our knowledge of their specific molecular modes of action is limited to the interaction with few cofactors. Here, we show that Hox proteins are able to interact with a wide range of transcription factors in the live Drosophila embryo. In this context, specificity relies on a versatile usage of conserved short linear motifs (SLiMs), which, surprisingly, often restrains the interaction potential of Hox proteins. This novel buffering activity of SLiMs was observed in different tissues and found in Hox proteins from cnidarian to mouse species. Although th…
Disruption of apical-basal polarity of human embryonic stem cells enhances hematoendothelial differentiation
2007
Abstract During murine development, the formation of tight junctions and acquisition of polarity are associated with allocation of the blastomeres on the outer surface of the embryo to the trophoblast lineage, whereas the absence of polarization directs cells to the inner cell mass. Here, we report the results of ultrastructural analyses that suggest a similar link between polarization and cell fate in human embryos. In contrast, the five human embryonic stem cell (hESC) lines displayed apical-basal, epithelial-type polarity with electron-dense tight junctions, apical microvilli, and asymmetric distribution of organelles. Consistent with these findings, molecules that are components of tigh…
Defining the genomic signature of totipotency and pluripotency during early human development.
2013
The genetic mechanisms governing human pre-implantation embryo development and the in vitro counterparts, human embryonic stem cells (hESCs), still remain incomplete. Previous global genome studies demonstrated that totipotent blastomeres from day-3 human embryos and pluripotent inner cell masses (ICMs) from blastocysts, display unique and differing transcriptomes. Nevertheless, comparative gene expression analysis has revealed that no significant differences exist between hESCs derived from blastomeres versus those obtained from ICMs, suggesting that pluripotent hESCs involve a new developmental progression. To understand early human stages evolution, we developed an undifferentiation netw…
Liberal and Conservative Differential Item Functioning Detection Using Mantel-Haenszel and SIBTEST: Implications for Type I and Type II Error Rates
2004
The aim of this work was to determine, in terms of Type I and Type II error rates, the risks of applying various statistical procedures for evaluating differential item functioning. To this end, the authors carried out a simulation study in which the Mantel-Haenszel and SIBTEST procedures were applied in conjunction. The variables manipulated were sample size and distribution of ability between groups. Results indicated that, although there was a high rate of agreement between the procedures, the joint Type I and Type II error rate may vary substantially from that obtained when each of the procedures was applied separately. Furthermore, the authors analyzed empirical data to obtain informat…
Tetra- and pentachlorodibenzothiophenes are formed in waste combustion
1991
Abstract Two different waste combustion samples have been analyzed for tetra- and pentachlorodibenzothiophenes. HRGC/HRMS with a resolution of 20 000 was used for identification. By resolution of 10 000 chlorinated dibenzo-p-dioxins and some unknown compounds gave GC/SIM peaks at the exact masses of the chlorinated dibenzothiophenes. These peaks were no more present by resolution 20 000. Several tetra- and pentachlorodibenzothiophenes were found in both samples. In the other one of the samples the concentrations were seemingly high although exact quantitative determination could not be done.
Estrategias para la elaboración de modelos estadísticos de regresión
2011
Multivariable regression models are widely used in health science research, mainly for two purposes: prediction and effect estimation. Various strategies have been recommended when building a regression model: a) use the right statistical method that matches the structure of the data; b) ensure an appropriate sample size by limiting the number of variables according to the number of events; c) prevent or correct for model overfitting; d) be aware of the problems associated with automatic variable selection procedures (such as stepwise), and e) always assess the performance of the final model in regard to calibration and discrimination measures. If resources allow, validate the prediction mo…
Fenibuta piemaisījumu kvantitatīvas noteikšanas metodes optimizācija un validācija
2021
Kokina. P., zinātniskie vadītāji: Dr. ķīm. V. Bartkevičs (LU), Dr. ķīm. A. Bolotin (AS Olainfarm). Maģistra darbs, 147 lappuses, 184 attēli, 75 tabulas, 15 literatūras avoti, 16 pielikumi. Latviešu valodā. Maģistra darbā ir veikta divu piemaisījumu(4-amino-3-fenilbutānskābes etilestera hidrohlorīds un 4-fenil-2-pirrolidons) kvantitatīvas noteikšanas analīzes metodes optimizācija un validācija farmaceitiskā preperāta Noofen® aktīvajai farmaceitiskai vielai (AFV) fenibuts. Metodes optimizācija un validācija bija nepieciešama farmaceitiskā preparāta Noofen® kvalitātes kontroles vajadzībām. Fenibuta paraugi tika analizēti ar augsti efektīvo šķidruma hromatogrāfiju (AEŠH). Optimizācija tika vērs…