Search results for "Tonicity"

Hypertonic Stress and Amino Acid Deprivation Both Increase Expression of mRNA for Amino Acid Transport System A

2004

The activity of amino acid transport system A ([Oxender and Christensen, 1963][1]) is regulated in a variety of different ways, the best studied being the increases of its activity caused by starving cells of amino acids or by exposing them to hypertonicity (for review see [McGivan and Pastor-

Stabilization of hsp70 mRNA on prolonged cell exposure to hypertonicity

2002

AbstractProlonged exposure of 3T3 cells to 0.5 osM hypertonic medium induced the accumulation of hsp70 mRNAs. This increase in mRNA levels required active protein synthesis. A weak and transient activation of heat shock factor 1 (HSF1) was noted, but it was temporally uncoupled to the accumulation of the hsp70 mRNAs. Nuclear run-on assay and transfection experiments showed that hsp70 gene transcription was not affected by hypertonicity. ActD chase experiments showed that during hypertonic treatment, degradation of hsp70 mRNAs was markedly reduced. This effect did not appear to be a general phenomenon since the increase in mRNA level of another gene induced by hypertonicity (ATA2 transporter…

Overview of Prognostic Systems for Hepatocellular Carcinoma and ITA.LI.CA External Validation of MESH and CNLC Classifications

2021

Simple Summary This review proposes a comprehensive overview of the main prognostic systems for HCC classified as prognostic scores, staging systems, or combined systems. Prognostic systems for HCC are usually compared in terms of homogeneity, monotonicity of gradients, and discrimination ability. However, despite the great number of published studies comparing HCC prognostic systems, it is rather difficult to identify a system that could be universally accepted as the best prognostic scheme for all HCC patients encountered in clinical practice. In order to give a contribute in this topic, we conducted a study aimed at externally validate the MESH score and the CNLC classification using the…

MECHANISM OF INHIBITION OF GASTRIC ACID SECRETION BY HYPERTONIC SOLUTIONS

1978

Influence of impregnation solution viscosity and osmolarity on solute uptake during vacuum impregnation of apple cubes (var. Granny Smith)

2008

Vacuum-assisted impregnation of pectinmethylesterase (PME) solution has been recognized as an efficient pretreatment to improve the firmness of heat-treated fruit. In order to improve the control of solute infusion into fruit pieces, the effect of the osmolarity and viscosity of vacuum impregnation solution on solute penetration and distribution was studied in 1.5 cm apple cubes, using model PME-based solutions containing sodium chloride and/or sodium alginate. While vacuum impregnation of either a viscous hypotonic or a non-viscous hypertonic solution infused solutes homogeneously into fruit pieces, the penetration of viscous hypertonic solutions was much lower, and PME or chloride infusio…

An Adaptive Alternating Direction Method of Multipliers

2021

AbstractThe alternating direction method of multipliers (ADMM) is a powerful splitting algorithm for linearly constrained convex optimization problems. In view of its popularity and applicability, a growing attention is drawn toward the ADMM in nonconvex settings. Recent studies of minimization problems for nonconvex functions include various combinations of assumptions on the objective function including, in particular, a Lipschitz gradient assumption. We consider the case where the objective is the sum of a strongly convex function and a weakly convex function. To this end, we present and study an adaptive version of the ADMM which incorporates generalized notions of convexity and penalty…

Monotonicity and enclosure methods for the p-Laplace equation

2018

We show that the convex hull of a monotone perturbation of a homogeneous background conductivity in the $p$-conductivity equation is determined by knowledge of the nonlinear Dirichlet-Neumann operator. We give two independent proofs, one of which is based on the monotonicity method and the other on the enclosure method. Our results are constructive and require no jump or smoothness properties on the conductivity perturbation or its support.

Stochastic monotonicity in intergenerational mobility tables

2010

SUMMARY The aim of this paper is to test for stochastic monotonicity in intergenerational socio-economic mobility tables. In other words, we question whether having a parent from a high socio-economic status is never worse than having one with a lower status. Using existing inferential procedures for testing unconditional stochastic monotonicity, we first test a set of 149 intergenerational mobility tables in 35 different countries and find that monotonicity cannot be rejected in hardly any table. In addition, we propose new testing procedures for testing conditional stochastic monotonicity and investigate whether monotonicity still holds after conditioning on a number of covariates such as…

Monotonicity and local uniqueness for the Helmholtz equation

2017

This work extends monotonicity-based methods in inverse problems to the case of the Helmholtz (or stationary Schr\"odinger) equation $(\Delta + k^2 q) u = 0$ in a bounded domain for fixed non-resonance frequency $k>0$ and real-valued scattering coefficient function $q$. We show a monotonicity relation between the scattering coefficient $q$ and the local Neumann-Dirichlet operator that holds up to finitely many eigenvalues. Combining this with the method of localized potentials, or Runge approximation, adapted to the case where finitely many constraints are present, we derive a constructive monotonicity-based characterization of scatterers from partial boundary data. We also obtain the local…

Dimension bounds in monotonicity methods for the Helmholtz equation

2019

The article [B. Harrach, V. Pohjola, and M. Salo, Anal. PDE] established a monotonicity inequality for the Helmholtz equation and presented applications to shape detection and local uniqueness in inverse boundary problems. The monotonicity inequality states that if two scattering coefficients satisfy $q_1 \leq q_2$, then the corresponding Neumann-to-Dirichlet operators satisfy $\Lambda(q_1) \leq \Lambda(q_2)$ up to a finite-dimensional subspace. Here we improve the bounds for the dimension of this space. In particular, if $q_1$ and $q_2$ have the same number of positive Neumann eigenvalues, then the finite-dimensional space is trivial. peerReviewed