Search results for "Torf"
showing 10 items of 32 documents
ER+ Breast Cancers Resistant to Prolonged Neoadjuvant Letrozole Exhibit an E2F4 Transcriptional Program Sensitive to CDK4/6 Inhibitors
2018
AbstractPurpose: This study aimed to identify biomarkers of resistance to endocrine therapy in estrogen receptor–positive (ER+) breast cancers treated with prolonged neoadjuvant letrozole.Experimental Design: We performed targeted DNA and RNA sequencing in 68 ER+ breast cancers from patients treated with preoperative letrozole (median, 7 months).Results: Twenty-four tumors (35%) exhibited a PEPI score ≥4 and/or recurred after a median of 58 months and were considered endocrine resistant. Integration of the 47 most upregulated genes (log FC > 1, FDR < 0.03) in letrozole-resistant tumors with transcription-binding data showed significant overlap with 20 E2F4-regulated genes (P =…
Diffusion of Drone Journalism: the Case of Finland, 2011-2020
2020
This article details Finnish news organizations’ adoption of drones for journalistic purposes from 2011 to 2020. The theoretical starting point of the article is Rogers’ (1962) diffusion of innovations theory, which explains how new ideas and technologies spread in societies. The main empirical data for the study were derived from a phone survey conducted among the 80 most popular newspapers in Finland. The findings reveal that drone journalism in Finland has already diffused from a few pioneering organizations to a large number of newsrooms, including regional, mid-sized newspapers. Most of the newspapers are either using in-house drones, buying commissioned images, or using both strategie…
Hybrid Engagement: Discourses and Scenarios of Entrepreneurial Journalism
2018
Although the challenge posed by social media and the participatory turn concerns culture and values at the very heart of journalism, journalists have been reluctant to adopt participatory values and practices. To encourage audience participation and to offer journalism that is both trustworthy and engaging, journalists of the future may embrace a hybrid practice of journalistic objectivity and audience-centred dialogue. As innovative and experimental actors, entrepreneurial journalism outlets can perform as forerunners of such a culture. By analysing discourses in the “About Us” pages of 41 entrepreneurial journalism outlets, the article examines the emerging journalistic ethos of entrepren…
First Measurement of Transverse-Spin-Dependent Azimuthal Asymmetries in the Drell-Yan Process
2017
The first measurement of transverse-spin-dependent azimuthal asymmetries in the pion-induced Drell-Yan (DY) process is reported. We use the CERN SPS 190 GeV/$c$, $\pi^{-}$ beam and a transversely polarized ammonia target. Three azimuthal asymmetries giving access to different transverse-momentum-dependent (TMD) parton distribution functions (PDFs) are extracted using dimuon events with invariant mass between 4.3 GeV/$c^2$ and 8.5 GeV/$c^2$. The observed sign of the Sivers asymmetry is found to be consistent with the fundamental prediction of Quantum Chromodynamics (QCD) that the Sivers TMD PDFs extracted from DY have a sign opposite to the one extracted from semi-inclusive deep-inelastic sc…
The ATLAS Data Acquisition and High Level Trigger system
2016
Journal of Instrumentation 11(06), P06008 (2016). doi:10.1088/1748-0221/11/06/P06008
Il Palazzo Cutò di Bagheria
1995
Disegnata dal frate Giuseppe Mariani, la villa-palazzo di Luigi Naselli, Principe di Aragona, fu edificata nella seconda decade del Settecento. Attraverso una originale indagine archivistica la monografia ricostruisce le fasi della sua edificazione, le trasformazioni, l'importante passaggio di proprietà ai Filangeri di Cutò nel 1803, i rifacimenti intervenuti nelle sale interne tra la metà dell'Ottocento e i primi del Novecento, i rapporti con il fenomeno più ampio dell'architettura delle ville. Lo studio si interrompe con il primo dopoguerra, che registra il passaggio dalla proprietà aristocratica - la villa era stata ereditata da Giuseppe Tomasi di Lampedusa - ad alcuni gruppi familiari d…
Conceptual design of the AGATA 1$\pi$ array at GANIL
2017
The Advanced GAmma Tracking Array (AGATA) has been installed at the GANIL facility, Caen-France. This setup exploits the stable and radioactive heavy-ions beams delivered by the cyclotron accelerator complex of GANIL. Additionally, it benefits from a large palette of ancillary detectors and spectrometers to address in-beam γ-ray spectroscopy of exotic nuclei. The set-up has been designed to couple AGATA with a magnetic spectrometer, charged-particle and neutron detectors, scintillators for the detection of high-energy γ rays and other devices such as a plunger to measure nuclear lifetimes. In this paper, the design and the mechanical characteristics of the set-up are described. Based on sim…
Study of the material of the ATLAS inner detector for Run 2 of the LHC
2017
The ATLAS inner detector comprises three different sub-detectors: the pixel detector, the silicon strip tracker, and the transition-radiation drift-tube tracker. The Insertable B-Layer, a new innermost pixel layer, was installed during the shutdown period in 2014, together with modifications to the layout of the cables and support structures of the existing pixel detector. The material in the inner detector is studied with several methods, using a low-luminosity root s = 13 TeV pp collision sample corresponding to around 2.0 nb(-1) collected in 2015 with the ATLAS experiment at the LHC. In this paper, the material within the innermost barrel region is studied using reconstructed hadronic in…
Journalists’ Associations as Political Instruments in Central and Eastern Europe
2017
This editorial provides the overall context for the five cases—three national and two international—covered in this thematic issue. While the cases are from Central and Eastern Europe (CEE), they highlight fundamental questions of journalism everywhere, including contradictions between freedom and control, professionalism and politics, individual and collective. The associations of journalists serve as very useful platforms to study these questions, especially at historical turning points when the whole political system changed, as happened twice in CEE after World War II.