Search results for "Trace"

showing 10 items of 3218 documents

La scoperta, sistemazione e conservazione della grande Iscrizione di Gortina, nell'isola di Creta (1884-1921): la protezione delle testimonianze e le…

2013

La scoperta e la conservazione della Grande Iscrizione di Gortina a Creta, da parte degli studiosi italiani, fra la fine del XIX sec. e i primi decenni del XX sec., rappresentò un grande riconoscimento scientifico-culturale per la giovane nazione italiana. Nel passato, l’isola di Creta era stata legata alla Repubblica di Venezia e anche questo rapporto favorì l’invio a Creta del giovane epigrafista F. Halbherr, il quale fra notevoli peripezie rinvenne, assieme all’epigrafista tedesco E. Fabricius, la famosa l’iscrizione nell’antica città di Gortina. L’iscrizione, fra le più antiche e complete finora conosciute in tutta Europa, conteneva le norme sulla famiglia, l’eredità e in generale i dir…

The discovery and preservation of the Great Inscription of Gortyna in Crete by Italian researchers in the late nineteenth century. and the first decades of the twentieth century. was an important cultural and scientific recognition for the young Italian nation. In the past the island of Crete had been tied to the Republic of Venice and this report also favored sending in Crete the young epigraphist F. Halbherr who among considerable vicissitudes came to together to the epigraphist german E. Fabricius the inclusion of the famous ancient city of Gortyna. The inscription among the oldest and most comprehensive so far known throughout Europe the rules contained on the family's legacy in general and the rights and duties of some of the people of the Minoan civilization (480-450 BC). The inscription was carved on blocks organic limestone a restored ancient building which later in Roman times was turned into odeon. The Laws of Gortyn were engraved on the remains of the wall forming the passageway in front of the steps of the odeon. The essay traces the events that led to the discovery and subsequent storage made by Halbherr especially with the help of archaeologist L. Pernier and finally with the help of architect E. Stefani who designed a modern cover on the top of the ambulatory of the segments containing the inscription. This coverage was made to perform during the First World War on the basis of the Italian project from the Greek Government in order to protect the membership from possible war damage but especially from vandalism. The roof brick clay of the Laws of Gortyna still serves its function and ensures the use of the monument bearing witness to the preservation of Italian culture in Greece and more generally in the world. But in Sicily in the remains of the Villa del Casale in Piazza Armerina (Enna) its elegant protection (built in 1957) is representative of a whole period of culture of the Italian restoration is removed and replaced because it has not been able to make a ongoing maintenance is due. A bad example of conservation and management of a UNESCO monument from which arise after the work for the construction of new roofs an equally insulting to the archaeological heritage and scenic Italian and world.Settore ICAR/19 - Restauro
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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Traducción y recepción: Rosalía de Castro en Italia

2020

El panorama de la recepción italiana contemporánea de los poetas españoles del siglo XIX, a través de las traducciones, no resulta especialmente satisfactorio, puesto que hay que esperar el siglo siguiente para encontrar los primeros estudios monográficos y ediciones de textos en traducción, aunque en forma antológica. Ello, no obstante, así como en el resto de Europa, el corpus de las publicaciones periódicas de las revistas ofrece un canal editorial muy proficuo para la recepción de textos literarios extranjeros. Este trabajo se centra en la presencia de la obra de Rosalía de Castro en la prensa italiana contemporánea. Al mismo tiempo, se ha intentado completar el estudio de la recepción …

The panorama of the contemporary Italian reception of the Spanish poets of the 19th century through translations is not particularly satisfactory since it is necessary to wait for the following century to find the first monographic studies and editions of texts in translation although in anthological form. However as in the rest of Europe the corpus of periodicals of magazines offers a very profitable editorial channel for receiving foreign literary texts. This work focuses on the presence of Rosalía de Castro's work in the contemporary Italian press. At the same time attempts have been made to complete the study of the reception of the Galician poet in Italy collecting traces in other editorial products such as the book. The consequent analytical focus will correspond to the transnational study of some proto and meta texts individualized by their special interest.
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Analyses of the TRACE V5 capability for the simulation of natural circulation and primary/containment coupling in BDBA condition typical of the MASLWR

2014

In the short term period the use of advanced Small Modular Reactor (SMR) is one of the most promising options for the deployment of nuclear technology. The validation and assessment of the best estimate thermal hydraulic system code TRACE against SMR thermal hydraulic phenomena is a novel effort. In this framework the use of the natural circulation database developed at the OSU-MASLWR test facility, simulating the MASLWR reactor prototype, is of interest for analyses of the TRACE code capability in predicting natural circulation and primary/containment coupled behavior in SMR. The target of this paper is to analyze the TRACE V5 capability for the simulation of natural circulation phenomena,…

Thermal hydraulicsEngineeringNatural circulationPrimary (chemistry)ContainmentCoupling (computer programming)business.industryNuclear engineeringMass flow ratebusinessSimulationTRACE (psycholinguistics)Small modular reactor
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Inhibition of in vitro macrophage-induced low density lipoprotein oxidation by thyroid compounds

2003

Oxidized low density lipoproteins (LDL) are highly suspected of initiating the atherosclerosis process. Thyroid hormones and structural analogues have been reported to protect LDL from lipid peroxidation induced by Cu2+ or the free radical generator 2,2'-azobis-'2-amidinopropane' dihydrochloride in vitro. We have examined the effects of thyroid compounds on macrophage-induced LDL oxidation. Human monocyte-derived macrophages (differentiated U937 cells) were incubated for 24 h with LDL and different concentrations (0-20 microM) of 3,5,3'-triiodo-l -thyronine (T3), 3,5,3',5'-tetraiodo-L-thyronine (T4), 3,3',5'-tri-iodo-l -thyronine (rT3), the T3 acetic derivative (3,5,3'-tri-iodothyroacetic a…

Thyroid Hormonesmedicine.medical_specialtyMacrophagesEndocrinology Diabetes and MetabolismU937 CellsThiobarbituric Acid Reactive SubstancesRedoxIn vitroLipoproteins LDLLipid peroxidationchemistry.chemical_compoundEndocrinologyEndocrinologychemistryIn vivoLow-density lipoproteinInternal medicineTBARSmedicineHumansLipid PeroxidationViability assayIntracellularJournal of Endocrinology
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Gold Nanoparticles Supported on Nanoparticulate Ceria as a Powerful Agent against Intracellular Oxidative Stress

2012

Ceria-supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO2 shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO2 against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO2 exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO2 carrier. Overall the result presented here shows the potential of implementing well-established …

Time FactorsAntioxidantMaterials scienceBiocompatibilityCell SurvivalPolymersPeroxidase activitymedicine.medical_treatmentMetal NanoparticlesApoptosisBiocompatible MaterialsIntracellular oxidative stressmedicine.disease_causeAntioxidantsCatalysisCell LineBiomaterialsHeLachemistry.chemical_compoundCeriaQUIMICA ORGANICAmedicineHumansNanotechnologyGold nanoparticlesGeneral Materials ScienceCell Proliferationchemistry.chemical_classificationReactive oxygen speciesbiologyGeneral ChemistryGlutathionebiology.organism_classificationOxidative StressNanomedicinePeroxidasesBiochemistrychemistryColloidal goldNanoparticlesGoldReactive Oxygen SpeciesIntracellularOxidative stressHeLa CellsBiotechnologySmall
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Side-specific effects by cadmium exposure: Apical and basolateral treatment in a coculture model of the blood–air barrier

2010

Cadmium (Cd{sup 2+}) is a widespread environmental pollutant, which is associated with a wide variety of cytotoxic and metabolic effects. Recent studies showed that intoxication with the heavy metal most importantly targets the integrity of the epithelial barrier. In our study, the lung epithelial cell line, NCI H441, was cultured with the endothelial cell line, ISO-HAS-1, as a bilayer on a 24-well HTS-Transwell (registered) filter plate. This coculture model was exposed to various concentrations of CdCl{sub 2}. The transepithelial electrical resistance decreased on the apical side only after treatment with high Cd{sup 2+} concentrations after 48 h. By contrast, a breakdown of TER to less t…

Time FactorsCell SurvivalToxicologyTight JunctionsProinflammatory cytokineAlveolar cellsCadmium ChlorideCell Line TumorElectric ImpedancemedicineHumansViability assayRespiratory systemFragmentation (cell biology)Cell ShapePharmacologyBlood-Air BarrierDose-Response Relationship DrugChemistryCell PolarityEndothelial CellsEpithelial CellsBlood–air barrierAdherens JunctionsMolecular biologyCoculture TechniquesEndothelial stem cellmedicine.anatomical_structureCytoprotectionImmunologyCytokinesCalciumInflammation MediatorsIntracellularToxicology and Applied Pharmacology
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Differential vesicular targeting and time course of synaptic secretion of the mammalian neurotrophins.

2005

Neurotrophins are a family of secreted neuronal survival and plasticity factors comprising NGF, BDNF, neurotrophin-3 (NT-3), and NT-4. Whereas synaptic secretion of BDNF has been described, the routes of intracellular targeting and secretion of NGF, NT-3, and NT-4 in neurons are poorly understood.To allow for a direct comparison of intracellular targeting and release properties, all four mammalian neurotrophins were expressed as green fluorescent protein fusion proteins in cultured rat hippocampal neurons. We show that BDNF and NT-3 are targeted more efficiently to dendritic secretory granules of the regulated pathway of secretion (BDNF, in 98% of cells; NT-3, 85%) than NGF (46%) and NT-4 (…

Time FactorsDevelopment/Plasticity/RepairBiologyHippocampal formationHippocampusPC12 CellsPostsynaptic potentialChlorocebus aethiopsAnimalsHumansSecretionNerve Growth FactorsCells CulturedGeneral NeuroscienceConstitutive secretory pathwaySynapsinFusion proteinCell biologyRatsnervous systemCOS CellsSynapsesbiology.proteinSynaptic VesiclesIntracellularNeurotrophinThe Journal of neuroscience : the official journal of the Society for Neuroscience
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Neurons and ECM regulate occludin localization in brain endothelial cells

2000

We report that extracellular matrix and neurons modulate the expression of occludin, one of the main components of tight junctions, by rat brain endothelial cells (RBE4.B). Of the three extracellular matrix proteins which we tested (collagen I, collagen IV, and laminin), collagen IV stimulated at the best the expression of occludin mRNA. The corresponding protein, however, was not synthesized. Significant amounts of occludin accumulated only when RBE4.B cells were cultured on collagen IV-coated inserts, in the presence of cortical neurons, plated on laminin-coated companion wells. Finally, occludin segregated at the cell periphery, only when endothelial cells were co- cultured with neurons …

Time FactorsEndothelial cellsCellOccludinTight JunctionsExtracellular matrixRats Sprague-DawleyFetusLamininNeurofilament ProteinsOccludinSettore BIO/10 - BiochimicaGlial Fibrillary Acidic ProteinmedicineAnimalsRNA MessengerCells CulturedBlood-brain barrierNeuronsbiologyTight junctionGeneral NeuroscienceBrainMembrane ProteinsCortical NeuronsExtracellular matrixImmunohistochemistryCell biologyRatsEndothelial stem cellmedicine.anatomical_structureMembrane proteinCell cultureSettore CHIM/09 - Farmaceutico Tecnologico ApplicativoCerebrovascular Circulationbiology.proteinSettore MED/26 - NeurologiaCollagenEndothelium VascularLamininNeuroscience
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Has long-term metal exposure induced changes in life history traits and genetic diversity of the enchytraeid worm Cognettia sphagnetorum (Vejd.)?

2004

We studied whether long-term metal exposure has affected life history traits, population growth patterns and genetic diversity of the asexual enchytraeid worm Cognettia sphagnetorum (Vejd.). Enchytraeids from metal contaminated and uncontaminated forest soil were compared by growing them individually in the laboratory and by following their population development in patchily Cu contaminated microcosms. Genetic differences between the two native populations were studied using allozyme electrophoresis. Individuals from the contaminated site had slower growth rate and they produced fewer fragments of larger size when compared to individuals from the uncontaminated site. In patchily Cu contamin…

Time FactorsGenotypeHealth Toxicology and MutagenesisPopulationBiologyToxicologyLife history theoryGene FrequencyAnimalsBody SizeSoil PollutantsOligochaetaLife historyAlleleeducationAllelesEcosystemClonal diversityeducation.field_of_studyGenetic diversityCognettia sphagnetorumEcologyGenetic VariationEnvironmental ExposureGeneral MedicinePollutionTrace ElementsGenetics PopulationMicrocosmCopperEnvironmental Pollution
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