Search results for "Trim"
showing 10 items of 1942 documents
Centrins in retinal photoreceptor cells: regulators in the connecting cilium.
2008
Changes in the intracellular Ca2+ concentration regulate the visual signal transduction cascade directly or more often indirectly through Ca2+-binding proteins. Here we focus on centrins, which are members of a highly conserved subgroup of the EF-hand superfamily of Ca2+-binding proteins in photoreceptor cells of the vertebrate retina. Centrins are commonly associated with centrosome-related structures. In mammalian retinal photoreceptor cells, four centrin isoforms are expressed as prominent components in the connecting cilium linking the light-sensitive outer segment compartment with the metabolically active inner segment compartment. Our data indicate that Ca2+-activated centrin isoforms…
Trimesic acid on Cu in ethanol: Potential-dependent transition from 2-D adsorbate to 3-D metal-organic framework
2017
We report the potential-dependent interactions of trimesic acid with Cu surfaces in EtOH. CV experiments and electrochemical surface-enhanced Raman spectroscopy show the presence of an adsorbed trimesic acid layer on Cu at potentials lower than 0 V vs Cu. The BTC coverage increases as the potential increases, reaching a maximum at 0 V. Based on molecular dynamics simulations, we report adsorption geometries and possible structures of the organic adlayer. We find that, depending on the crystal facet, trimesic acid adsorbs either flat or with one or two of the carboxyl groups facing the metal surface. At higher coverages, a multi-layer forms that is composed mostly of flat-lying trimesic acid…
Heterometallic Titanium-Organic Frameworks as Dual Metal Catalysts for Synergistic Non-Buffered Hydrolysis of Nerve Agent Simulants
2020
Heterometallic metal-organic frameworks (MOFs) can offer important advantages over their homometallic counterparts to enable targeted modification of their adsorption, structural response, electronic structure, or chemical reactivity. However, controlling metal distribution in these solids still remains a challenge. The family of mesoporous titanium-organic frameworks, MUV-101(M), displays heterometallic TiM2 nodes assembled from direct reaction of Ti(IV) and M(II) salts. We use the degradation of nerve agent simulants to demonstrate that only TiFe2 nodes are capable of catalytic degradation in non-buffered conditions. By using an integrative experimental-computational approach, we rational…
Disassembly of structurally modified viral nanoparticles: characterization by fluorescence correlation spectroscopy.
2005
Abstract Analysis of the breakdown products of engineered viral particles can give useful information on the particle structure. We used various methods to breakdown both a recombinant enveloped virus and virus-like particles (VLPs) from two non-enveloped viruses and analysed the resulting subunits by fluorescence correlation spectroscopy (FCS). Analysis of the enveloped baculovirus, Autographa californica multicapsid nucleopolyhedrovirus (AcMNPV), displaying the green fluorescent protein (GFP) fused to its envelope protein gp64 was performed in the presence and absence of 5 mM SDS and 25 mM DTT. Without treatment, the viral particle showed a diffusion time of 3.3 ms. In the presence of SDS…
Efficient synthesis of quaternary and P-stereogenic phosphonium triflates
2010
An efficient and general method for the preparation of achiral and chiral phosphonium salts is reported. This synthesis is based on the quaternization of phosphines and their derivatives with arynes generated in situ from 2-(trimethylsilyl)aryl triflates. This methodology is successfully applied to the synthesis of new valuable P-stereogenic phosphonium triflates.
Mainstream digitale e altre immagini urbane. Una ricerca empirica nel sito UNESCO di Palermo
2021
The research deepens the role of new technologies in the construction of geographical imaginaries investigating the dimension of the offer related to the cultural heritage of the city of Palermo. The study was conducted using qualitative methods and provided for the application of two research techniques: participant observation and semi-structured interviews. By interpreting the results produced, the contribution aims to highlight the predominance of an urban image, linked to the UNESCO inclusion of the site in the World Heritage List, which is conveyed through new technologies. Developing a reflection on the alternative capacity of new media to dislocate and challenge shared images, the s…
Occurrence of antibiotics and risk of antibiotic resistance evolution in selected Kenyan wastewaters, surface waters and sediments
2019
Active pharmaceutical ingredients, especially antibiotics, are micropollutants whose continuous flow into hydrological cycles has the potential to mediate antibiotic resistance in the environment and cause toxicity to sensitive organisms. Here, we investigated the levels of selected antibiotics in four wastewater treatment plants and the receiving water bodies. The measured environmental concentrations were compared with the proposed compound-specific predicted no-effect concentration for resistance selection values. The concentration of doxycycline, amoxicillin, sulfamethoxazole, trimethoprim, ciprofloxacin and norfloxacin within the influents, effluents, surface waters and river sediments…
Los sistemas de regadío tradicional en el interior valenciano. La vega requenense del río Magro y sus maniantiales
2001
La Vega del río Magro, en su tramo requenense, atesora un rico patrimonio ligado al uso tradicional del agua. A lo largo de ambas márgenes del río se encuentra un valioso sistema de regadío, recorrido por varias acequias, que amén de facilitar la irrigación de los campos permitió durante décadas el funcionamiento de una veintena de artilugios hidráulicos (molinos). De la misma manera la regulación y ordenación del uso del agua del río y de manantiales contribuyen en el valor patrimonial del citado sistema. El objetivo de este artículo es la revalorización de los antiguos sistemas de regadío y todos sus elementos que, a lo largo de la historia, han configurado un paisaje cultural no siempre …
La giurisdizione nelle cause tra coniugi secondo la normativa europea
2014
L’articolo esamina la normativa comunitaria in materia di processo civile, con particolare riferimento alle controversie tra i coniugi. Nella prima parte, l’Autore illustra le competenze dell’Unione europea nel settore della cooperazione giudiziaria in materia civile ed esamina le disposizioni sulla competenza giurisdizionale nelle cause tra coniugi in materia di divorzio, separazione personale e annullamento del matrimonio, contenute nel regolamento (CE) n. 2201/2003, c.d. Bruxelles II bis. Nella seconda parte dell’articolo, l’Autore illustra le norme sulla competenza giurisdizionale contenute negli altri regolamenti rilevanti e procede ad un esame comparativo delle diverse disposizioni. I…
Approche responsable pour le patrimoine : coopération, participation, documentation / Approccio responsabile al patrimonio architettonico: cooperazio…
2014
Nel quadro del Programma Italie Tunisie, l’esperienza del Progetto APER viene introdotta con riferimento ai diversi livelli e alle opportunità della cooperazione: tra realtà transfrontaliere, tra istituzioni dello stesso Paese e tra studiosi di diverse discipline. Passando ai contenuti scientifici, dopo aver illustrato il campo di applicazione e le potenziali ricadute, si pone l’accento sul tema dell’integrazione tra salvaguardia e valorizzazione, come sintesi teorica e operativa degli obiettivi del Progetto APER. Seguendo l’evoluzione dell’approccio al patrimonio architettonico, dall’origine dello stesso concetto allo sviluppo degli obiettivi della conservazione prima e della valorizzazion…