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showing 10 items of 10618 documents
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Global Real-World Evidence of Sofosbuvir/Velpatasvir as a Highly Effective Treatment and Elimination Tool in People with Hepatitis C Infection Experi…
2022
HCV elimination; Mental health disorders; Sofosbuvir/velpatasvir Eliminación del VHC; Trastornos de salud mental; Sofosbuvir/velpatasvir Eliminació del VHC; Trastorns de salut mental; Sofosbuvir/velpatasvir Hepatitis C virus (HCV) is prevalent in people with mental health disorders, a priority population to diagnose and cure in order to achieve HCV elimination. This integrated analysis pooled data from 20 cohorts in seven countries to evaluate the real-world effectiveness of the pangenotypic direct-acting antiviral (DAA) sofosbuvir/velpatasvir (SOF/VEL) in people with mental health disorders. HCV-infected patients diagnosed with mental health disorders who were treated with SOF/VEL for 12 w…
Measuring, comparing and interpreting phenotypic selection on floral scent
2022
Natural selection on floral scent composition is a key element of the hypothesis that pollinators and other floral visitors drive scent evolution. The measure of such selection is complicated by the high-dimensional nature of floral scent data and uncertainty about the cognitive processes involved in scent-mediated communication. We use dimension reduction through reduced-rank regression to jointly estimate a scent composite trait under selection and the strength of selection acting on this trait. To assess and compare variation in selection on scent across species, time and space, we reanalyse 22 datasets on six species from four previous studies. The results agreed qualitatively with prev…
Study on the Influence of Economic and Social Factors on the Financing of National Defense
2020
In the Romanian literature and current research, the financing of national defense is a less debated topic. Most studies are conducted mainly for developed countries, which also have the most advanced military systems and focus only on the correlation between military spending and the economy. The objective of the paper is to investigate the correlation between the evolution of military spending in Romania during 1919-2012 on the one hand, and economic, political and social factors, on the other. The empirical study performed used the linear regression model, estimated by the least squares method (OLS), using the statistical software EViews 10. The results of the study showed that the level…
Nieru audzēju klīniski morfoloģiskais raksturojums
2020
Saslimstība ar ļaundabīgajiem nieru audzējiem palielinās katru gadu, visizteiktāk tas vērojams pasaules attīstītajās valstīs, kā arī Latvijā. Nieru šūnu karcinoma ir viens no visbiežākajiem ļaundabīgajiem nieru audzējiem. Agrīnajās stadijās nieru šūnu karcinomai nav raksturīga kāda konkrēta simptomātika un lielākajā daļā gadījumu, tā tiek diagnosticēta netīši- veicot izmeklējumus kādas citas saslimšanas gadījumā. Pēc tam, kad audzējs ir ticis diagnosticēts, ir būtiski izvērtēt pacienta vispārējo stāvokli un riska faktorus, no kā ir atkarīga pacientu kopējā dzīvildze un recidīva risks. Ja iespējams, noteikt histoloģisko nieru šūnu karcinomas subtipu un ņemot vērā šos faktorus, izvēlēties pie…
"She's been an exemplar of modern, fit and confident middle age" : representations of Michelle Obama in three English-language newspapers
2018
Median vastuullinen tehtävä on luoda representaatioita eli kuvauksia yhteiskunnallisista ilmiöistä ja tapahtumista, jotka muovaavat käsitystämme maailmasta. Näin tehdessään se luo representaatioita myös ihmisistä. Nämä representaatiot ilmentävät erilaisia arvoja, asenteita ja ajattelutapoja. Yhdysvaltain ensimmäiset naiset edustavat maataan presidentin rinnalla ja ovat jatkuvan tarkkailun alaisina. Obamat olivat ensimmäinen afroamerikkalainen presidenttipari ja siksi erityisen mediahuomion kohteena. Michelle Obamaa sekä ylistettiin että kritisoitiin mediassa, sillä hän toimi poikkeuksellisen aktiivisesti politiikassa ja ilmaisi mielipiteensä avoimesti. Tämän tutkielman tarkoituksena on tark…
The Warriors' Cult : representations of masculinity on the subreddit /r/TheRedPill
2018
Internet on yksi arkemme merkittävimmistä informaation lähteistä ja kantaa sisällään paljon mielenkiintoista sisältöä. Reddit on moniaiheinen internet- ja keskustelusivusto, jonka yksi kiehtovimmista yhteisöistä (subredditeistä) on /r/TheRedPill. Yhteisö kuvailee itseään seuraavasti: “The Red Pill: Keskustelua seksuaalisesta strategiasta kulttuurissa, jossa on vähenevissä määrin positiivisia identiteettejä miehille”. Vuosien 2017 ja 2018 aikana mediassa on keskusteltu paljon miehistä ja huomattavan usein heitä on kritisoitu esimerkiksi epäsopivasta seksuaalikäyttäytymisestä. Halusin omassa tutkimuksessani sukeltaa sisälle yhteisöön, joka pyrkii voimaannuttamaan miehiä yhteiskunnallisen kesk…
The Car Resequencing Problem with Pull-Off Tables
2011
AbstractThe car sequencing problem determines sequences of different car models launched down a mixed- model assembly line. To avoid work overloads of workforce, car sequencing restricts the maximum occurrence of labor-intensive options, e.g., a sunroof, by applying sequencing rules. We consider this problem in a resequencing context, where a given number of buffers (denoted as pull-off tables) is available for rearranging a stirred sequence. The problem is formalized and suited solution procedures are developed. A lower bound and a dominance rule are introduced which both reduce the running time of our graph approach. Finally, a real-world resequencing setting is investigated.
Portico, peristilio e ombracolo. Forme di resistenza tra gli spazi di transizione mediterranei
2023
The direct and indirect consequences of climate change and its repercussions on man and the environment are a cherished theme in the field of architectural composition; human designed settlements have always been confronted with the changing conditions of the environmental context. Defined as a 'special watchdog', the Mediterranean Sea is de facto, the place where climate change is evolving most rapidly and where impacts will intensify in the near future. The force of the changing issues of climate change is to highlight - once again - the indissoluble relationship between man and the environment, the existence of very long-term processes, the responsibility and the impact of human human ch…