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showing 10 items of 1060 documents
DiseaseLinc: Disease Enrichment Analysis of Sets of Differentially Expressed LincRNAs
2021
Long intergenic non-coding RNAs (LincRNAs) are long RNAs that do not encode proteins. Functional evidence is lacking for most of them. Their biogenesis is not well-known, but it is thought that many lincRNAs originate from genomic duplication of coding material, resulting in pseudogenes, gene copies that lose their original function and can accumulate mutations. While most pseudogenes eventually stop producing a transcript and become erased by mutations, many of these pseudogene-based lincRNAs keep similarity to the parental gene from which they originated, possibly for functional reasons. For example, they can act as decoys for miRNAs targeting the parental gene. Enrichment analysis of fun…
Scientists’ engagement in knowledge transfer and exchange: Individual factors, variety of mechanisms and users
2018
[EN] This article aims to provide a deeper understanding of the individual factors behind scientists' involvement in a wide variety of knowledge transfer and exchange (KTE) activities. By doing so, the article addresses three major shortcomings in the literature. First, this article considers scientists' involvement in both formal and informal KTE activities. Secondly, the study focuses not only on KTE activities with the private sector, but also with other types of agents. Thirdly, the article adopts an individual approach to distinguish between three types of KTE predictors: individual capacities, training and career trajectories, and motivations. Overall, the results of the regression mo…
The analysis of urban travellers’ latent preferences to explain their mode choice behaviour
2012
Our research aims to explore the impact of latent variables, mirroring urban travellers’ attitudes and perceptions, on the individual decision making process regarding the mode of transport. The paper describes the first results of an ongoing research activity, which derive from a pilot study conducted in Palermo, the capital of the Sicilian Region (in the south of Italy), and demonstrate that policy makers, in designing a socially desirable and environmentally sustainable urban mobility system, should take into account how travellers perceive the qualitative dimensions of transport.
German Registry for Acute Aortic Dissection Type A (GERAADA)--new software design, parameters and their definitions.
2011
BACKGROUND The working group for aortic surgery and interventional vascular surgery of the German Society for Thoracic and Cardiovascular Surgery (GSTCVS) initiated the web-based German Registry for Acute Aortic Dissection type A (GERAADA). It is the project's aim to collect standardized data from a large pool of patients with acute aortic dissections type A (AADA) to gain a deeper insight and knowledge to improve surgical therapies and perioperative management for these patients in the future. METHODS In addition to new medical insights, the working group has gained more experience over the last 4 years in how to collect valid and high-quality data. This experience led us to revise the dat…
A Deep Learning Approach for Energy Efficient Computational Offloading in Mobile Edge Computing
2019
Mobile edge computing (MEC) has shown tremendous potential as a means for computationally intensive mobile applications by partially or entirely offloading computations to a nearby server to minimize the energy consumption of user equipment (UE). However, the task of selecting an optimal set of components to offload considering the amount of data transfer as well as the latency in communication is a complex problem. In this paper, we propose a novel energy-efficient deep learning based offloading scheme (EEDOS) to train a deep learning based smart decision-making algorithm that selects an optimal set of application components based on remaining energy of UEs, energy consumption by applicati…
Demo: Co-simulation of UAVs with INTO-CPS and PVSio-web
2018
This demo shows our ongoing work on the co-simulation of co-operative Unmanned Aerial Vehicles (UAVs). The work is based on the INTO-CPS co-simulation engine, which adopts the widely accepted Functional Mockup Interface (FMI) standard for co-simulation, and the PVSioweb prototyping tool, that extends a system simulator based on the PVS logic language with a web-based graphical interface. Simple scenarios of Quadcopters with assigned different tasks, such as rendez-vous and space coverage, are shown. We assumed a linearized dynamic model for Quadcopters formalized in OpenModelica, and a linearized set of equations for the flight control module written in C language. The co-ordination algorit…
Strategies for annotation and curation of translational databases: the eTUMOUR project
2012
Altres ajuts: LSHC/CT2004-503094 The eTUMOUR (eT) multi-centre project gathered in vivo and ex vivo magnetic resonance (MR) data, as well as transcriptomic and clinical information from brain tumour patients, with the purpose of improving the diagnostic and prognostic evaluation of future patients. In order to carry this out, among other work, a database-the eTDB-was developed. In addition to complex permission rules and software and management quality control (QC), it was necessary to develop anonymization, processing and data visualization tools for the data uploaded. It was also necessary to develop sophisticated curation strategies that involved on one hand, dedicated fields for QC-gene…
Opportunities for Strategic Public Relations : Evaluation of International Research and Innovation Project Dissemination
2018
Abstract European industry, academia and potential end users for future solutions are widely involved in applying for European Union (EU) funding of research and innovation and implementation of the projects. Funding instrument requirements emphasise the influence of skills and know-how of these project consortia professionals. This chapter proposes a co-creative model for communication and dissemination, or project PR, based on the experiences of both planning and coordinating dissemination activities of three EU funded projects. Multidisciplinary international project Public Relations (PR) offers strategic opportunities for PR professionals. The model employs the co-creation methods based…
Solution NMR structure of aD,L-alternating oligonorleucine as a model of ?-helix
2001
beta-Helix structures are of particular interest due to their capacity to form transmembrane channels with different transport properties. However, the relatively large number of beta-helices configurations does not allow a direct conformational analysis of beta-helical oligopeptides. A synthetic alternating D,L-oligopeptide with twelve norleucines (XIIMe) has been used as a model to get insight in the conformational features of beta-helix structures. The spatial configuration of XIIMe in solution has been determined by NMR. An extensive set of distances (nuclear Overhauser effect) and dihedral (J coupling constants) constraints have been included in molecular dynamics calculations. The NMR…
Evolution of patients’ socio-behavioral characteristics in the context of DAA: Results from the French ANRS CO13 HEPAVIH cohort of HIV-HCV co-infecte…
2018
International audience; BACKGROUND:Direct-acting antivirals (DAA) have dramatically increased HCV cure rates with minimal toxicity in HIV-HCV co-infected patients. This study aimed to compare the socio-behavioral characteristics of patients initiating pegylated-interferon (PEG-IFN)-based HCV treatment with those of patients initiating DAA-based treatment.METHODS:ANRS CO13 HEPAVIH is a national multicenter prospective cohort started in 2005, which enrolled 1,859 HIV-HCV co-infected patients followed up in French hospital outpatient units. Both clinical/biological and socio-behavioral data were collected during follow-up. We selected patients with socio-behavioral data available before HCV tr…