Search results for "Uses"

Legumes in 21st century Europe: present and future importance in agri-food systems? New challenges for reseach.

2013

Intensification of agriculture since 1950 has globally led to the decline of grain legume crops, which currently represent less than 3 % of arable crops in France and Europe. Nevertheless, legumes have several major assets (i) as plant proteins for animal feed and human food and (ii) as plants fixing atmospheric N2 and thereby saving nitrogen inputs in cropping systems, and (iii) as diversification crops. The analysis of forage and grain legume producing systems in France showed that the dominant system results in a lock-in of the different factors limiting legume insertion into the current systems. But legumes could have a major role to play in the agroecological transition towards more su…

Agrīnā pusaudzības vecumposma skolēnu sociāli emocionālās veselības rādītāju izmaiņas dzīvesspēka un stipro pušu intervences programmā

2018

Galvenais pētījuma mērķis bija izstrādāt un realizēt dzīvesspēka un stipro pušu intervences programmu agrīnā pusaudzības vecumposma skolēniem eksperimentālā grupā (N=19; M=11,3; zēni n=12, meitenes n=7), un salīdzināt SEV faktora rezultātus pirms un pēc intervences programmas ar skolēniem kontrolgrupā (N=19; M=11,2; zēni n=6, meitenes n=13). Testēšana notika divos posmos – pirms un pēc intervences programmas, izmantojot “Sociāli emocionālās veselības aptaujas” testu pusaudžiem (Furlong, 2015; adapt. Kņaze, 2017), kā instrumentu dzīves kvalitātes izpratnei un to panākumu un labklājības prognozēšanai gan tagadnē, gan tālākajā dzīvē. Skolēniem tika pasniegtas 11 intervences nodarbības, attīsto…

A Bayesian Reconstruction of a Historical Population in Finland, 1647–1850

2020

This article provides a novel method for estimating historical population development. We review the previous literature on historical population time-series estimates and propose a general outline to address the well-known methodological problems. We use a Bayesian hierarchical time-series model that allows us to integrate the parish-level data set and prior population information in a coherent manner. The procedure provides us with model-based posterior intervals for the final population estimates. We demonstrate its applicability by estimating the long-term development of Finlands population from 1647 onward and simultaneously place the country among the very few to have an annual popula…

Réflexions sur les relations entre système alimentaire, système agricole et services écosystémiques : le cas des légumineuses

2013

Cytoplasmic Parvovirus Capsids Recruit Importin Beta for Nuclear Delivery

2019

Parvoviruses are an important platform for gene and cancer therapy. Their cell entry and the following steps, including nuclear import, are inefficient, limiting their use in therapeutic applications. Two models exist on parvoviral nuclear entry: the classical import of the viral capsid using nuclear transport receptors of the importin (karyopherin) family or the direct attachment of the capsid to the nuclear pore complex leading to the local disintegration of the nuclear envelope. Here, by laser scanning confocal microscopy and in situ proximity ligation analyses combined with coimmunoprecipitation, we show that infection requires importin β-mediated access to the nuclear pore complex and …

Tres artistas en el exilio: Max Aub, Félix Candela y Josep Renau

2020

Three artists in exile focuses on the historical diaspora provoked by the Spanish civil war (1936- 1939), and how it influenced three prominent figures of the cultural scene of that period: the writer and typographer Max Aub Mohrenwitz (Paris, 1903-Ciudad de Mexico, 1972); the architect Félix Candela Outeriño (Madrid, 1910-Raleigh, US, 1977); and the artist Josep Renau Berenguer (Valencia, 1907-Berlín, 1982). They are the three protagonists of this article, who were simultaneously living in Mexico during the exile and who made notable contributions in the fields of arts and humanities (Max Aub), architecture (Félix Candela), and graphic design and photomontage (Josep Renau). While they were…

Structural Insight into CVB3-VLP Non-Adjuvanted Vaccine

2020

Coxsackievirus B (CVB) enteroviruses are common pathogens that can cause acute and chronic myocarditis, dilated cardiomyopathy, aseptic meningitis, and they are hypothesized to be a causal factor in type 1 diabetes. The licensed enterovirus vaccines and those currently in clinical development are traditional inactivated or live attenuated vaccines. Even though these vaccines work well in the prevention of enterovirus diseases, new vaccine technologies, like virus-like particles (VLPs), can offer important advantages in the manufacturing and epitope engineering. We have previously produced VLPs for CVB3 and CVB1 in insect cells. Here, we describe the production of CVB3-VLPs with enhanced pro…

Neuropeptidome regulation after baculovirus infection. A focus on proctolin and its relevance in locomotion and digestion

2020

AbstractBaculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues. Some behavioral and physiological changes in lepidopteran larvae have been described following a baculovirus infection and those changes could be connected with alterations in the host’s central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters or neuromodulators. These peptides are involved in regulating animal physiology…

A proctolin-like peptide is regulated after baculovirus infection and mediates in caterpillar locomotion and digestion

2022

Baculoviruses constitute a large group of invertebrate DNA viruses, predominantly infecting larvae of the insect order Lepidoptera. During a baculovirus infection, the virus spreads throughout the insect body producing a systemic infection in multiple larval tissues, included the central nervous system (CNS). As a main component of the CNS, neuropeptides are small protein-like molecules functioning as neurohormones, neurotransmitters, or neuromodulators. These peptides are involved in regulating animal physiology and behavior and could be altered after baculovirus infection. In this study, we have investigated the effect of Spodoptera exigua multiple nucleopolyhedrovirus (SeMNPV) infection …

Phage therapy

2013

Bacteriophage therapy, the use of viruses that infect bacteria as antimicrobials, has been championed as a promising alternative to conventional antibiotics. Although in the laboratory bacterial resistance against phages arises rapidly, resistance so far has been an only minor problem for the effectiveness of phage therapy. Resistance to antibiotics, however, has become a major issue after decades of extensive use. Should we expect similar problems after long-term use of phages as antimicrobials? Like antibiotics, phages are often noted to be drivers of bacterial evolution. Should we expect phage-treated pathogens to develop a general resistance to phages over time, a resistance against whi…