Search results for "WIDE"
showing 10 items of 1235 documents
Polymorphisms of an innate immune gene, toll-like receptor 4, and aggressive prostate cancer risk: a systematic review and meta-analysis.
2014
Background: Toll-like receptor 4 (TLR4) is one of the best known TLR members expressed on the surface of several leukocytes and tissue cells and has a key function in detecting pathogen and danger-associated molecular patterns. The role of TLR4 in the pathophysiology of several age-related diseases is also well recognized, such as prostate cancer (PCa). TLR4 polymorphisms have been related to PCa risk, but the relationship between TLR4 genotypes and aggressive PCa risk has not been evaluated by any systematic reviews. Methods: We performed a systematic review and meta-analysis of candidate-gene and genome-wide association studies analyzing this relationship and included only white populatio…
Impact of Gamma Radiation on Dynamic RDSON Characteristics in AlGaN/GaN Power HEMTs
2019
GaN high-electron-mobility transistors (HEMTs) are promising next-generation devices in the power electronics field which can coexist with silicon semiconductors, mainly in some radiation-intensive environments, such as power space converters, where high frequencies and voltages are also needed. Its wide band gap (WBG), large breakdown electric field, and thermal stability improve actual silicon performances. However, at the moment, GaN HEMT technology suffers from some reliability issues, one of the more relevant of which is the dynamic on-state resistance (R) regarding power switching converter applications. In this study, we focused on the drain-to-source on-resistance (R) characteristic…
ETP/GDOP Behavior Study for N-Sensors Arrays ina Multilateration Radar System
2009
In this paper, we evaluated the ETP (Expected Theoretical Precision) and GDOP (Geometric Dilution Of Precision) enhancement related to the number of sensors in a Multilateration radar system. An introduction about the principles of the Multilateration radar system basis operation is described, then, the formulation for evaluation the ETP/GDOP of the 3D positioning is shown. We observed that the ETP and GDOP enhance with the increase of the number of sensors. A substantial improvement was obtained until nine sensors but, for more sensors that improvement is reduced. Results for a 75km×75km area are shown, including LAM (Local Area Multilateration) and WAM (Wide Area Multilateration) settings…
Using UDDI for Publishing Metadata of the Semantic Web
2006
Although UDDI does not provide support for semantic search, retrieval and storage, it is already accepted as an industrial standard and a huge number of services already store their service specifications in UDDI. Objective of this paper is to analyze possibilities and ways to use UDDI registry to allow utilization of meta-data encoded according to Semantic Web standards for semantic-based description, discovery and integration of web resources in the context of needs of two research projects: “Adaptive Services Grid” and “SmartResource”. We present an approach of mapping RDFS upper concepts to UDDI data model using tModel structure, which makes possible to store semantically annotated reso…
Statistical colocalization of monocyte gene expression and genetic risk variants for type 1 diabetes
2012
One mechanism by which disease-associated DNA variation can alter disease risk is altering gene expression. However, linkage disequilibrium (LD) between variants, mostly single-nucleotide polymorphisms (SNPs), means it is not sufficient to show that a particular variant associates with both disease and expression, as there could be two distinct causal variants in LD. Here, we describe a formal statistical test of colocalization and apply it to type 1 diabetes (T1D)-associated regions identified mostly through genome-wide association studies and expression quantitative trait loci (eQTLs) discovered in a recently determined large monocyte expression data set from the Gutenberg Health Study (1…
The Childhood Leukemia International Consortium
2013
Abstract Background : Acute leukemia is the most common cancer in children under 15 years of age; 80% are acute lymphoblastic leukemia (ALL) and 17% are acute myeloid leukemia (AML). Childhood leukemia shows further diversity based on cytogenetic and molecular characteristics, which may relate to distinct etiologies. Case–control studies conducted worldwide, particularly of ALL, have collected a wealth of data on potential risk factors and in some studies, biospecimens. There is growing evidence for the role of infectious/immunologic factors, fetal growth, and several environmental factors in the etiology of childhood ALL. The risk of childhood leukemia, like other complex diseases, is like…
A Holonic Approach to Shakespeare: The Digital Reference System (DRS)
2012
Prefatory RemarksWhen hypertext was made available on the Internet after 1994 it shaped the concepts of public domain and free access. The web server and browsing system that Tim Berners-Lee and Robert Cailliau designed, determined the future digital, editorial and cultural developments for traditional audiences and digital natives alike. They quickly became the generalized interface tools and thus contributed to today's editorial standards. As they helped to create this innovative environment called the Internet, they also helped to establish many standards such as URL, URI, HTTP HTML or XML, which provided interoperability amongst different platforms and allowed internationalization.Shake…
Genome-wide DNA profiling of marginal zone lymphomas identifies subtype-specific lesions with an impact on the clinical outcome
2011
Abstract Marginal zone B-cell lymphomas (MZLs) have been divided into 3 distinct subtypes (extranodal MZLs of mucosa-associated lymphoid tissue [MALT] type, nodal MZLs, and splenic MZLs). Nevertheless, the relationship between the subtypes is still unclear. We performed a comprehensive analysis of genomic DNA copy number changes in a very large series of MZL cases with the aim of addressing this question. Samples from 218 MZL patients (25 nodal, 57 MALT, 134 splenic, and 2 not better specified MZLs) were analyzed with the Affymetrix Human Mapping 250K SNP arrays, and the data combined with matched gene expression in 33 of 218 cases. MALT lymphoma presented significantly more frequently gain…
Integrated Domain Model for Digital Rights Management
2004
Digital Rights Management (DRM) is an issue of controlling and managing digital rights over intellectual property. It has recently broadened its scope from being merely a content protection concern to description, identification, trading, protection, monitoring and tracking of rights over tangible or intangible assets. In our study we found out an essential problem of the domain: lack of models on an appropriate level of abstraction needed to support research and system development. Modelling, identifying and describing the core entities enable the rights management functionalities. This chapter contributes in recognizing the principal entities and providing detailed description on current …
Efficient Model Repository for Web Applications
2018
Many model-based applications have been developed with standalone usage in mind. When migrating such applications to the web, we have to think about multiple users competing for limited server resources. In addition, we encounter the need to synchronize models via the network for client-side access. Thus, there is the risk that the model storage could become a bottleneck.