Search results for "ZEPA"
showing 10 items of 106 documents
Diversity-Oriented Stereocontrolled Synthesis of Some Piperidine- and Azepane-Based Fluorine-Containing β-Amino Acid Derivatives
2020
AbstractStructural diversity-oriented synthesis of some azaheterocyclic β-amino acid derivatives has been accomplished by selective functionalization of readily available cyclodienes. The stereocontrolled synthetic concept was based on the oxidative ring cleavage of unsaturated cyclic β-amino acids derived from cycloalkadiene, followed by ring closing with double reductive amination, which furnished some conformationally restricted β-amino acid derivatives with a piperidine or azepane core.
Studies on metal-drug complexes. Crystal structure and characterization of μ-sulfato bromazepam copper(II) complex
1987
Abstract The compound Cu(Bromazepam) SO 4 having been synthesized, its crystal structure shows distorted octahedral environment for the Copper(II) ion. Because of the long Cu-O(4) length (2.90 A), we can consider that there is a semicoordinative interaction with the sulfate group acting as tridentate bridging ligand. The structure is a polymeric chain where dimeric units are linked by the oxygen (C-O(5)) atom of the Bromazepam carbonyl group. The drug consequently acts as a tridentate ligand in this compound. The magnetic results show a very weak antiferromagnetic interaction.
A micellar liquid chromatographic method for quality control of pharmaceutical preparations containing tricyclic antidepressants
2002
Micellar liquid chromatography methods for quality control of pharmaceutical preparations (capsules, pills, tablets, injections) containing the tricyclic antidepressants amineptine, amitriptiline, clomipramine, doxepin, imipramine, melitracen and nortriptyline alone or together with other CNS drugs like diazepam, medazepam and perphenazine are described. The methods using micellar solutions of cetyltrimethylammonium bromide as mobile phases and UV detection are rapid and reproducible. Due to the versatility of interactions in micellar liquid chromatography, it is possible determine highly hydrophobic compounds such as TCAs in a short time using mobile phases containing low organic solvent c…
Synthesis of fluorinated piperidine and azepane β-amino acid derivatives
2016
Abstract A convenient and robust stereocontrolled procedure has been developed for the synthesis of novel trifluoromethyl-containing piperidine and azepane β-amino ester stereoisomers. The synthesis started from readily available unsaturated bicyclic β-lactams and was based on oxidative cleavage of the ring C C double bond followed by ring closure of the diformyl intermediates in the presence of 2,2,2-trifluoroethylamine hydrochloride through reductive amination. The synthetic procedure has efficiently been extended towards the synthesis of mono- and difluorinated analogs.
Reductive Metabolism of P-Nitrobenzoic Acid and Nitrazepam in the Isolated Perfused Rat Liver in the Presence of Ethanol
1978
Reductive metabolism of aromatic nitro compounds has been shown to play a minor role under aerobic conditions and to reach maximal activities under anoxia (Jonen-Kern et al., Xenobiotica, in press). We have shown that in the presence of ethanol maximal activities can be obtained even under aerobic conditions.
Ogniwo paliwowe zasilane emulsją oleju rzepakowego
2017
W pracy przedstawiono badania nad możliwością wykorzystania oleju rzepakowego jako substancji czynnej do zasilania ogniwa paliwowego. W tym celu zbudowano testowe ogniwo paliwowe. Ogniwo zasilano emulsją oleju rzepakowego. Jako detergent zastosowano Syntanol DS-10. Wykorzystano anodę z katalizatorem platynowym oraz katodę z katalizatorem Ni-Co. Pomiary przeprowadzono w temperaturze 293–333K. Maksymalna uzyskana gęstość prądu wynosiła 2 mA/cm2, natomiast maksymalna moc ogniwa 21 mW (dla temp. 333K). Wykazano, więc możliwość bezpośredniego dostarczania oleju rzepakowego (w formie emulsji) na anodę. Uzyskana moc ogniwa była stosunkowo niska, jednak istnieje możliwość zbudowania ogniwa paliwowe…
Compatibilidad de las ZEPA con otras actividades y usos del territorio
2016
Este trabajo trata de mostrar la complejidad que supone la ordenación de las Zonas de Especial Protección para las Aves (ZEPAs), debido a la abundante diversidad de los ecosistemas y otros problemas socioeconómicos. A causa de sus especiales características, es crucial establecer modelos de planificación y criterios que sirvan para ponderar de forma efectiva la compatibilidad entre la protección y la conservación de la naturaleza con el desarrollo sostenible. This paper aims to show how Birds Special Protection Areas (SPAs) have complex structures due to the high diversity of their ecosystems and the specific socio-economic problems. Given these special characteristics, it is crucial to set…
?-Carboline binding indicates the presence of benzodiazepine receptor subclasses in the bovine central nervous system
1982
Receptor binding studies were performed with tritiated propyl β-carboline-3-carboxylate ([3H]PrCC), tritiated ethyl β-carboline-3-carboxylate ([3H]ECC), and tritiated flunitrazepam ([3H]FNT) in membrane preparations from different regions of the bovine brain and retina. Specific binding in all regions investigated was associated with benzodiazepine receptor sites. However, not all benzodiazepine receptor sites. However, not all benzodiazepine receptors in the regions investigated as determined by the specific binding of tritiated flunitrazepam ([3H]FNT) are available for [3H]PrCC suggesting that specific [3H]PrCC binding labels only one subclass or subpopulation of the benzodiazepine recept…
Effects of Different Anxiety Levels on the Behavioral Patternings Investigated through T-pattern Analysis in Wistar Rats Tested in the Hole-Board App…
2021
The Hole-Board is an ethologically based tool for investigating the anxiety-related behavior of rats following manipulation of the central anxiety level. The present paper aims to assess behavioral patterning following pharmacological manipulation of emotional assets in Wistar rats tested in this experimental apparatus. For this purpose, the behavior of three groups of rats injected with saline, diazepam or FG7142 was evaluated using conventional quantitative and multivariate Tpattern analyses. The results demonstrate that quantitative analyses of individual components of the behavior, disjointed from the comprehensive behavioral structure, are of narrow utility in the understanding of the …
Behavioural responsiveness to picrotoxin and desipramine in adult rats prenatally exposed to different benzodiazepine receptor agonists
1995
The behavioural responsiveness to picrotoxin and desipramine was investigated in adult rats prenatally exposed to different benzodiazepine receptor agonists such as diazepam, alprazolam and zolpidem. Prenatal exposure to diazepam and alprazolam similarly potentiated the anti-immobility effect on the forced swimming test and the inhibitory effect on spontaneous motor activity of picrotoxin and desipramine and increased the seizure sensitivity to picrotoxin. Prenatal zolpidem seems to be ineffective. These data suggest that, despite the differences in their pharmacodynamic profile, prenatal exposure to diazepam and alprazolam, but not zolpidem, may have similar permanent consequences on the b…