Search results for "acting"
showing 10 items of 338 documents
The 1-loop effective potential for the Standard Model in curved spacetime
2018
The renormalisation group improved Standard Model effective potential in an arbitrary curved spacetime is computed to one loop order in perturbation theory. The loop corrections are computed in the ultraviolet limit, which makes them independent of the choice of the vacuum state and allows the derivation of the complete set of $\beta$-functions. The potential depends on the spacetime curvature through the direct non-minimal Higgs-curvature coupling, curvature contributions to the loop diagrams, and through the curvature dependence of the renormalisation scale. Together, these lead to significant curvature dependence, which needs to be taken into account in cosmological applications, which i…
Renormalisation group improvement in the stochastic formalism
2019
We investigate compatibility between the stochastic infrared (IR) resummation of light test fields on inflationary spacetimes and renormalisation group running of the ultra-violet (UV) physics. Using the Wilsonian approach, we derive improved stochastic Langevin and Fokker-Planck equations which consistently include the renormalisation group effects. With the exception of stationary solutions, these differ from the naive approach of simply replacing the classical potential in the standard stochastic equations with the renormalisation group improved potential. Using this new formalism, we exemplify the IR dynamics with the Yukawa theory during inflation, illustrating the differences between …
Planck-scale effects on WIMP dark matter
2014
There exists a widely known conjecture that gravitational effects violate global symmetries. We study the effect of global-symmetry violating higher-dimension operators induced by Planck-scale physics on the properties of WIMP dark matter. Using an effective description, we show that the lifetime of the WIMP dark matter candidate can satisfy cosmological bounds under reasonable assumptions regarding the strength of the dimension-five operators. On the other hand, the indirect WIMP dark matter detection signal is significantly enhanced due to new decay channels.
Fitting formulae for photon spectra from WIMP annihilation
2011
Annihilation of different dark matter (DM) candidates into Standard Model (SM) particles could be detected through their contribution to the gamma ray fluxes that are measured on the Earth. The magnitude of such contributions depends on the particular DM candidate, but certain imprints of produced photon spectra may be analyzed in a model-independent fashion. In this work we provide the fitting formulae for the photon spectra generated by WIMP annihilation into quarks, leptons and gauge bosons channels in a wide range of WIMP masses.
Collective features of Cr and Fe isotopes
2014
The question of the sudden increase of collectivity in neutron-rich nuclei when approaching N = 40 has recently interested both experimentalists and theorists. In this paper we study the development of collectivity along the chromium and iron isotopic chains. The calculations are performed within two different perspectives, namely, the proton-neutron interacting boson model (IBM-2) and interacting shell model (ISM) and compared with the available experimental data. The onset of collectivity is studied through nuclear quantities and observables that suggest differences in the nuclear structure of Cr and Fe isotopical chains. Furthermore, a prediction for the shape transition from a spherical…
Efficacy and Safety of Degludec versus Glargine in Type 2 Diabetes.
2017
BACKGROUND Degludec is an ultralong-Acting, once-daily basal insulin that is approved for use in adults, adolescents, and children with diabetes. Previous open-label studies have shown lower day-To-day variability in the glucose-lowering effect and lower rates of hypoglycemia among patients who received degludec than among those who received basal insulin glargine. However, data are lacking on the cardiovascular safety of degludec. METHODS We randomly assigned 7637 patients with type 2 diabetes to receive either insulin degludec (3818 patients) or insulin glargine U100 (3819 patients) once daily between dinner and bedtime in a double-blind, treat-To-Target, event-driven cardiovascular outco…
Insulin degludec and insulin glargine 300 U/mL: Which of these two insulins causes less hypoglycemia?
2019
The interesting article by Yamabe et al.1 showed, using continuous glucose monitoring, that insulin degludec (I‐Deg) was associated with a high percentage of time with nocturnal hypoglycemia than with insulin glargine 300 U/mL (I‐G300; P = 0.02). However, we observe that some possible confounding factors might have influenced the results, such as differences in concomitant medications, use of the same titration protocol for both kinds of insulin or differences in glucose levels. This is also a recurrent problem in clinical trials, which sometime produce conflicting results. In fact, the study of Yamabe et al. is partly in agreement with some recently published clinical trials that gave diff…
Rapid-Acting Insulin Analogues in Basal-Bolus Regimens in Type 1 Diabetes Mellitus
2010
ABSTRACT Objective To compare rapid-acting insulin analogues with regular human insulin in terms of hemoglobin A1c, hypoglycemia, and insulin dose when used in a basal-bolus regimen in patients with type 1 diabetes mellitus. Methods MEDLINE and congress proceedings were searched for randomized controlled trials comparing pran- dial insulins in a basal-bolus regimen in adults or children/ adolescents with type 1 diabetes. Studies in pregnancy, ob- servational studies, studies that compared premixed insulin or continuous subcutaneous insulin infusion/insulin pumps, and studies where the basal insulin was also changed were excluded. Only studies reporting baseline-endpoint change in insulin do…
A SIMPLE PARTICLE MODEL FOR A SYSTEM OF COUPLED EQUATIONS WITH ABSORBING COLLISION TERM
2011
We study a particle model for a simple system of partial differential equations describing, in dimension $d\geq 2$, a two component mixture where light particles move in a medium of absorbing, fixed obstacles; the system consists in a transport and a reaction equation coupled through pure absorption collision terms. We consider a particle system where the obstacles, of radius $\var$, become inactive at a rate related to the number of light particles travelling in their range of influence at a given time and the light particles are instantaneously absorbed at the first time they meet the physical boundary of an obstacle; elements belonging to the same species do not interact among themselves…
A trans-acting locus regulates an anti-viral expression network and type 1 diabetes risk
2010
Combined analyses of gene networks and DNA sequence variation can provide new insights into the aetiology of common diseases that may not be apparent from genome-wide association studies alone. Recent advances in rat genomics are facilitating systems-genetics approaches. Here we report the use of integrated genome-wide approaches across seven rat tissues to identify gene networks and the loci underlying their regulation. We defined an interferon regulatory factor 7 (IRF7)-driven inflammatory network (IDIN) enriched for viral response genes, which represents a molecular biomarker for macrophages and which was regulated in multiple tissues by a locus on rat chromosome 15q25. We show that Epst…