Search results for "actors"
showing 10 items of 11323 documents
The E3 Ubiquitin Ligase MID1 Catalyzes Ubiquitination and Cleavage of Fu
2014
Sonic Hedgehog (SHH)-GLI signalling plays an important role during embryogenesis and in tumorigenesis. The survival and growth of several types of cancer depend on autonomously activated SHH-GLI signalling. A protein complex containing the ubiquitin-ligase MID1 and protein phosphatase 2A (PP2A) regulates the nuclear localization and transcriptional activity of GLI3, a transcriptional effector molecule of SHH, in cancer cell lines with autonomously activated SHH signalling. However, the exact molecular mechanisms that mediate the interaction between MID1 and GLI3 remained unknown. Here, we show that MID1 catalyses the ubiquitination and proteasomal cleavage of the GLI3-regulator Fu. Our data…
Staphylococcus epidermidis virulences faktori un epidemioloģiskā nozīme
2016
Staphylococcus epidermidis svarīgākais virule nces faktors ir biofilmas veidošana. Lai diferencētu komensālos celmus no kolonizējošiem un invazīviem celmiem, pētījumā tika izmantotas fenotipiskās metodes, nosakot biofilmas veidošanu, antibiogrammu, un molekulārās bioloģijas metodes, nosakot virulences gēnus aap / ica A un mec A. Rezultāti liecina, ka biofilmu veidošana raksturīga klīniskajiem celmiem, statistiski ticami biežāk gēni aap/ica A bija noteikti klīniskajos S.epidermidis celmos, tie vis biežāk bija rezistenti pret meticilīnu (97,8%). S.epidermidis tipēšanai pirmo reizi tika pielietota MLST (multilokusu sekvenču tipēšana) metode. Pētījuma rezultāti ļauj secināt par S.epidermidis ge…
Pre-operative leukocytosis: a potential poor prognosis risk factor in cardiac device implantation: a case report
2022
Introduction. Despite the benefits of the implantation of cardiac rhythm management devices cardiac implantable electronic device (CIED) infection is an emerging problem New debate emerged about the unclear role of the pre-operative alteration of pro-inflammatory parameters, such as leukocytosis, in the development CIED infection and/or heart failure, and its consequent impact on the timing of ICD implantation/reimplantation. Case report. A 65 years old patient with a history of Diabetes Mellitus (DM) type II, ventricular and supraventricular arrhythmias, chronic myocardial ischemia, heart failure was admitted to hospital.Healthcare workers opted for ICD implantation despite the presence of…
ELECTROCHEMICAL MICROREACTORS FOR SYNTHESIS OF CHEMICALS AND ABATEMENT OF ORGANIC POLLUTTANTS
2014
Electrochemical methods can offer new sustainable routes for both the synthesis of chemicals and the abatement of organic pollutants resistant to biological processes. These methods use a clean reagent, the electron, and very mild operative conditions (ambient temperature and atmospheric pressure) with limited operative costs. However, electrochemical processes present some important disadvantages when performed in conventional reactors. In particular, to achieve reasonable cell voltages when the medium has not an adequate conductivity, one needs adding to the system a supporting electrolyte. This is certainly a main obstacle for a wide application of electrochemical tools. Indeed, adding c…
ABATEMENT OF ACID ORANGE 7 IN WATER BY DIFFERENT ELECTROCHEMICAL APPROACHES
2014
Very large amounts of synthetic dyes are discharged in the environment from industrial effluents [1]. Due to their large-scale production and extensive application, synthetic dyes can cause considerable nonaesthetic pollution and are serious health-risk factors [2]. Dyes are commonly classified from their chromophore group. The majority of these compounds consumed at industrial scale are azo (–N=N–) derivatives that represent more than 50% of the all dyes used in textile industries, although antraquinone, indigoide, triphenylmethyl, xanthene, sulphur and phtalocyanine derivatives are frequently utilized [3]. Since dyes usually present high stability under sunlight and resistance to microbia…
Mobile Technology Adoption and the Effects of Cultural Factors
2019
Mobile technologies are an important part of human life in both the personal and professional realms. Many services (banking, news, health, education, etc.) that traditionally offered either face-to-face, telephone, or other conventional platforms and technologies are now establishing services on mobile platforms as well. Mobile gadgets are now also being used by company employees as sales automation tools. The importance of culture in technology adoption and usage has been well-established. The adoption of any technology includes a set of factors that determine if the technology is either accepted or rejected, and the individual strengths of these determining factors may vary greatly, depe…
Comportements migratoires des étudiants et des jeunes diplômés.
2008
Until now, analyses about migrations of young people linked with French higher education seemed to focus only on costs and advantages. Especially students in training and young graduates integrating labour market. They consider strategies of job searching and studies efficiencies. Until now, these analyses about French students' and graduates' migrations didn't take into account geographical dimensions. From now, national databases allow studying regional migrations of both students and graduates. Now, one can answer to questions like: do they migrate the same way? Do regions influence the way they migrate? Main results are explained in three developments. The first one presents main charac…
Factors related to survival from oral cancer in an Andalusian population sample (Spain)
2007
Introduction: Approximately 3% of malignant tumors originate in the oral cavity. The majority are squamous cell carcinomas, and a small percentage, malignant tumors of the salivary glands, lymphoreticular diseases, bone tumors, melanomas, sarcomas, malignant odontogenic tumors and metastases of tumors from other locations. The prognosis of these pathologies depends on the size, infiltration, and site of the lesion, the presence or absence of metastatic spread, and to a certain degree the differentiation of the tumor. The prognosis of an oral cancer remains generally negative, with 5-year survival figures below 50%, producing high rates of mortality and morbidity. Objectives: To evaluate the…
Influence of voluntary work intervention on the mood status of older volunteers
2012
The aim of this study was to investigate the positive and depressive mood changes in older volunteers after a three-month voluntary work intervention through a one-group experimental research design. The participants were drawn from the Volunteering, access to Outdoor activities and Wellbeing in older people (VOW) project. The participants were recently retired group, aged 50 and above (N=47, 42 female). Prior training sessions were arranged for the participants before the intervention period. Pre and post assessment of depressive mood was measured through applying the original form of Center for Epidemiologic Studies Depression Scale (CES-D) and positive mood was measure through the positi…
FACTORES HUMANOS ASOCIADOS A LOS ACCIDENTES MORTALES DE MOTOCICLETAS SCOOTER EN ESPAÑA
2017
Resumen Los accidentes de motocicleta son uno de los problemas de seguridad vial más importantes a nivel mundial. Hay una escasez de estudios específicos sobre las características de la accidentalidad de las motocicletas de tipo scooter, motivada por la falta de una definición precisa de este tipo de motocicleta y de la identificación de los distintos tipos de vehículos de dos ruedas en los registros de accidentes. El objetivo de este trabajo es determinar las características de los 293 conductores de motocicletas scooter fallecidos en España durante el periodo 2006-2011. Se realizaron análisis descriptivos y de asociación en función de la naturaleza de las variables. Los resultados de los …