Search results for "aging"
showing 10 items of 10496 documents
Associations of Sex Hormones and Hormonal Status With Arterial Stiffness in a Female Sample From Reproductive Years to Menopause
2021
ObjectiveLoss of sex hormones has been suggested to underlie menopause-associated increment in cardiovascular risk. We investigated associations of sex hormones with arterial stiffness in 19–58-years-old women. We also studied associations of specific hormonal stages, including natural menstrual cycle, cycle with combined oral contraceptives (COC) and menopausal status with or without hormone therapy (HT), with arterial stiffness.MethodsThis study includes repeated measurements of 65 healthy women representing reproductive (n=16 natural, n=10 COC-users) and menopause (n=5 perimenopausal, n=26 postmenopausal, n=8 HT-users) stages. Arterial stiffness outcomes were aortic pulse wave velocity (…
Vascular Risk Factors in Mild Cognitive Impairment Subtypes
2007
<i>Background and Aim:</i> To investigate the role of vascular risk factors in different subtypes of mild cognitive impairment (MCI) in a multicentric, clinic-based, cross-sectional study. <i>Methods:</i> Two-hundred and seven subjects with MCI were included in the study: 33 with single non-memory MCI (snmMCI), 42 with multiple-domain amnestic MCI (mdMCI-a) and 132 with amnestic MCI (aMCI). Several clinical vascular risk factors and magnetic resonance imaging (MRI) brain lesions were evaluated. <i>Results:</i> snmMCI showed a higher frequency of ischaemic heart disease and of transient ischaemic attack (TIA)/stroke, a higher Hachinski ischaemic score and …
Kieliä rinnakkain : koulun monikielisyys näkyviin kieliä vertailemalla
2018
Millainen on minun arkeni kielimaisema? Miten kieleni tukevat toisiaan? Entä miten niiden käyttöä tuetaan? Onko oppilaan/hoitolapsen/työkaverin maisema samanlainen vai erilainen kuin omani? Tässä artikkelissa käsittelemme koulun kielikirjoa kielten näkyväksi tekemisen ja vertailun näkökulmasta. Keskitymme siihen, miten kielten havainnointi, maistelu ja analysointi herättelevät huomaamaan ympärillä puhuttuja kieliä, lisäävät kielitietoisuutta ja rohkaisevat käyttämään vähäistäkin kielitaitoa. nonPeerReviewed
Sustaining Attention for a Prolonged Duration Affects Dynamic Organizations of Frequency-Specific Functional Connectivity
2020
Sustained attention encompasses a cascade of fundamental functions. The human ability to implement a sustained attention task is supported by brain networks that dynamically formed and dissolved through oscillatory synchronization. The decrement of vigilance induced by prolonged task engagement affects sustained attention. However, little is known about which stage or combinations are affected by vigilance decrement. Here, we applied an analysis framework composed of weighted phase lag index (wPLI) and tensor component analysis (TCA) to an EEG dataset collected during 80 min sustained attention task to examine the electrophysiological basis of such effect. We aimed to characterize the phase…
English in interpretation to Finnish Sign Language : the forms and functions of chaining sequences in educational interpreting
2017
Tässä tutkimuksessa selvitettiin ketjutusta (chaining) kieleilyn (languaging) käytänteenä viittomakielen tulkkauksessa. Tutkimuskysymyksinä esitettiin, mitä semioottisia resursseja viittomakielen tulkit käyttivät englantia sisältävissä ketjutussekvensseissä sekä mitä funktioita em. sekvensseillä oli. Tutkimuksessa tuotettiin yksityiskohtaista kuvausta autenttisesta aineistosta. Tutkimuskohteena oli kolme englannin kielestä suomalaiselle viittomakielelle tulkattua korkeakoululuentoa. Luennot videoitiin ja niistä paikannettiin ne kohdat, joissa tulkkeessa esiintyi englantia. Nämä kohdat annotoitiin käyttäen ELAN-annotointiohjelmaa. Englantia sisältävät ketjutussekvenssit jaoteltiin muodon ja …
Soft X-ray Tomography Reveals HSV-1-Induced Remodeling of Human B Cells.
2022
Upon infection, viruses hijack the cell machinery and remodel host cell structures to utilize them for viral proliferation. Since viruses are about a thousand times smaller than their host cells, imaging virus-host interactions at high spatial resolution is like looking for a needle in a haystack. Scouting gross cellular changes with fluorescent microscopy is only possible for well-established viruses, where fluorescent tagging is developed. Soft X-ray tomography (SXT) offers 3D imaging of entire cells without the need for chemical fixation or labeling. Here, we use full-rotation SXT to visualize entire human B cells infected by the herpes simplex virus 1 (HSV-1). We have mapped the temporo…
Conception en technologie CMOS d'un Système de Vision dédié à l'Imagerie Rapide et aux Traitements d'Images
2008
Our work presented in this thesis focuses on the design, testing and implementation of monolithics CMOS image smart sensors : The principle, performance and limitations. The hardware implementation of a vision smart system is the central link. HISIC is High Speed Image Capture with processing at pixel level. An experimental platform for instrumentation and evaluation of retina operators was conducted during this thesis. After a state of the smart sensors and CMOS retinas, the second part is dedicated to the study and design of the pixel image sensor HISIC. Two circuits were realized in CMOS technology. The first identied a new type of photo-detector, and the second, to create a prototype em…
Visual Contrast Modulates Operant Learning Responses in Larval Zebrafish.
2018
The larval zebrafish is a promising vertebrate model organism to study neural mechanisms underlying learning and memory due to its small brain and rich behavioral repertoire. Here, we report on a high-throughput operant conditioning system for zebrafish larvae, which can simultaneously train 12 fish to associate a visual conditioned pattern with electroshocks. We find that the learning responses can be enhanced by the visual contrast, not the spatial features of the conditioned patterns, highlighted by several behavioral metrics. By further characterizing the learning curves as well as memory extinction, we demonstrate that the percentage of learners and the memory length increase as the co…
Long-term strength and balance training prevents mobility decline among community-dwelling people aged 75 and older
2016
High functional capacity of muscle strength and balance in older persons promotes independent mobility and prevents functional decline below the disability threshold. This dissertation explored the effects of strength and balance training (SBT) as part of a multimodal geriatric intervention on physical functioning and health-related factors associated with training participation in a community-dwelling population aged 75 years and over. This study is a part of the Geriatric Multidisciplinary Strategy for the Good Care of the Elderly (GeMS) project conducted from 2004 to 2007 in Kuopio, Finland. Participants were randomized into an intervention (n=339) and control group (n=312). The individu…
Accumulation of sensory difficulties predicts fear of falling in older women
2013
Objectives: To explore whether the accumulation of sensory difficulties predicts fear of falling (FOF), and whether the traits correlate with each other regardless of familial factors. Methods: Self-reported hearing, vision and balance difficulties, and FOF were assessed using structured questionnaires at the baseline and after a 3-year follow-up in 63- to 76-year-old women (n = 434). Results: Among the women without FOF at baseline (n = 245), 41% reported FOF at follow-up. Increasing numbers of sensory difficulties at baseline predicted higher incidence of FOF. The relationship between accumulated sensory difficulties and FOF was not mediated by familial factors. Discussion: The accumulati…