Search results for "alfa"
showing 10 items of 378 documents
Chemistry of detrifluoroacetylativelyin situgenerated fluoro-enolates
2018
This review article comprehensively profiles all literature reports (2015-2018) related to the detrifluoroacetylative in situ generation of fluorine-containing enolates and their reactions with electrophilic reagents. The innovative facets of this unconventional methodology and its synthetic generality for the preparation of fluorine-containing compounds of high medicinal value are highlighted.
La lettura ad alta voce per favorire lo sviluppo cognitivo ed emotivo del bambino
2023
L’esposizione precoce a pratiche di lettura ad alta voce rappresenta uno strumento fondamentale per lo sviluppo di facoltà cognitive, emotive e psi-cologiche già nella prima infanzia. La lettura ad alta voce è una pratica che se utilizzata fin dalla primissima infanzia è in grado di modellare il cer-vello sviluppando maggiormente circuiti cere-brali che supportano le abilità narrative. Nume-rose ricerche hanno evidenziato come la lettura ad alta voce già dal primo anno di vita favorisca lo sviluppo cognitivo ed emotivo del bambino e faciliti la costruzione di un rapporto positivo tra genitori e figli. La famiglia, pertanto, ha il compi-to principale di promuovere occasioni di lettura ad alt…
Induction of interferon regulatory factors, 2′‐5′ oligoadenylate synthetase, P68 kinase and RNase L in chronic myelogenous leukaemia cells and its re…
1996
The genes crucially determining the therapeutic response of chronic myelogenous leukaemia (CML) to interferon-alpha (IFN-alpha) are unknown. Recently, two independent IFN-alpha signalling pathways were identified: the classic pathway mediates induction of 2'-5' oligoadenylate synthetase (2-5 OAS), p68 kinase and IFN regulatory factor-2 (IRF-2), whereas the alternate pathway leads to activation of IFN regulatory factor-1 (IRF-1). We investigated whether deficient or imbalanced expression of components of these two pathways is associated with resistance of CML cells to antiproliferative action of IFN alpha/beta. Constitutive and IFN-induced transcript levels of IFN-dependent genes in mononucl…
Abnormalities in serum concentrations of interleukin-2, interferon-alpha and interferon-gamma in schizophrenia not detected.
1992
The hypothesis of an immunological defect in schizophrenia has been supported by reports on abnormal production of interleukin-2 (IL-2) and interferons (IFNs) in schizophrenic patients. In the present study we determined the serum concentrations of IL-2, IFN-alpha and IFN-gamma in 10 first onset, neuroleptic-naive schizophrenics, in 6 pretreated patients who were drug free (1 week to 2 years) at the time of the investigation and in 15 matched healthy controls. No IFN-alpha was detected in schizophrenics' and in control sera. No differences were found in IL-2 and IFN-gamma levels between schizophrenics and controls. Thus the present study failed to support the hypothesis of an immunological …
Development of oil cysts after subcutaneous injection of interferon-α and interleukin-2
2006
High dose infusion of activated protein C (rhAPC) fails to improve neuronal damage and cognitive deficit after global cerebral ischemia in rats
2013
Abstract Purpose : Recent studies demonstrated anticoagulatory, antiinflammatory, antiapoptotic, and neuroprotective properties of activated protein C (APC) in rodent models of acute neurodegenerative diseases, suggesting APC as promising broad acting therapeutic agent. Unfortunately, continuous infusion of recombinant human APC (rhAPC) failed to improve brain damage following cardiac arrest in rats. The present study was designed to investigate the neuroprotective effect after global cerebral ischemia (GI) with an optimized infusion protocol. Methods : Rats were subjected to bilateral clip occlusion of the common carotid arteries (BCAO) and controlled hemorrhagic hypotension to 40 mmHg for…
"Penso a Turandot non finita!". Riflessioni sul capolavoro incompiuto di Giacomo Puccini
2019
Il saggio ricostruisce gli ultimi mesi della vita di Giacomo Puccini, con particolare riferimento alla composizione del terzo atto di "Turandot", agli abbozzi lasciati dall'autore al momento della morte (Bruxelles 1924) e ai successivi interventi compositivi e di orchestrazione realizzati da Franco Alfano.
Ad occhi aperti. La notte in cui Puccini incontrò Manon
2021
Il testo analizza alcuni aspetti della biografia e dell'esperienza creativa di Giacomo Puccini con particolare riferimento alla genesi di Turandot (1920-24) e al problema del finale del terzo atto dell'opera The text analyzes some aspects of Giacomo Puccini's biography and creative experience with particular reference to the genesis of Turandot (1920-24) and the problem of the finale of the third act
“Teacher of Italian as a non-native language for low educated users”. A new professional profile
2017
We aim at describing a new professional profile, i.e. “Teacher of Italian as a non-native language for low educated users”, as it has been defining within the research and teaching experience at the School of Italian language for Foreigners of the University of Palermo. In last years, migrants’ cultural features and age have changed and an increasing amount of people landing on Italian shores is constituted by MSNA (Unaccompanied Foreign Minors), mostly belonging to the category of LESLLA. This scenario imposes the definition of new competences, suitable for the training needs of these new users. Teachers of Italian L2 have to acquire literacy skills, which traditionally do not fall within …
Valutazione e autovalutazione nei percorsi didattici per apprendenti bassamente scolarizzati: problemi e prospettive
2016
L’intervento affronta il problema delle forme e del ruolo della valutazione e dell’autovalutazione nei percorsi di apprendimento linguistico rivolti a utenti bassamente scolarizzati, con particolare riferimento all’italiano lingua non materna. Il tema dell’acquisizione delle L2 nei casi di bassa (o nulla) scolarizzazione è oggetto di un’attenzione crescente, sia sul piano teorico, sia su quello della progettazione di interventi didattici mirati. La domanda di lavoro nell’ambito della riflessione teorica è se e in che misura le abilità di scrittura, poiché richiedono una serie di operazioni cognitive complesse, condizionino lo sviluppo delle abilità orali in L2, in termini di strategie, form…