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Risperidona lietošana bērniem ar autismu vai šizofrēniju un ar to saistīto risku izvērtējums
2015
Risperidons ir efektīvs un plaši pielietots neiroleptiskais līdzeklis, kura lietošana bērniem ar autismu vai šizofrēniju bieži saistīta ar hiperprolaktinēmijas attīstīšanos. Pētījumā apkopoti dati par risperidona nozīmēšanas biežumu Bērnu Psihiatrijas Klīnikā, hiperpolaktinēmijas attīstības risku un to atkarību no bērna dzimuma. Darbā secināts, ka autisma un šizofrēnijas pacientiem pastāv ļoti augsts hiperprolaktinēmijas risks -61% autisma un 94% šizofrēnijas pacientiem noteikta risperidona izraisīta hiperprolaktinēmija. Pētījumā izvērtēta bērnu vecāku informētība par risperidona lietošanas riskiem. Pie hipeprolaktinēmijas autisma gadījumā pacientiem medicīniskās palīdzības pamatmetode ir r…
Trofisko čūlu terapija cukura diabēta pacientiem farmaceita praksē
2017
Cukura diabēts (CD) ir slimība, kas galvenokārt raksturojas ar glikozes vielmaiņas traucējumiem. Atkarībā no CD veida, organisms pats neizstrādā insulīnu no aizkuņģa dziedzera β-šūnām (pilnīga destrukcija) (1.tips), vai nespēj izmantot insulīnu pareizi (insulīna rezistence) (2. tips) [American Diabetes Association, 2011]. Šī pētījuma mērķis bija noskaidrot trofisko čūlu esamības biežumu CD pacientu vidū un noskaidrot farmaceita lomu šo brūču terapijā, analizējot 2016.gada aptauju rezultātus, kuras tika veiktas Rīgas 1. Slimnīcas un ģimenes ārstu prakses aptiekās Rīgā. Darbā tika analizētas atbildes no pacientu un no ārstu aptaujām, pēc kurām tika noskaidrota pēdu problēmu vēsture, pašreizēj…
Capillary Liquid Chromatography for the Determination of Terpenes in Botanical Dietary Supplements
2021
Dietary supplements of botanical origin are increasingly consumed due to their content of plant constituents with potential benefits on health and wellness. Among those constituents, terpenes are gaining attention because of their diverse biological activities (anti-inflammatory, antibacterial, geroprotective, and others). While most of the existing analytical methods have focused on establishing the terpenic fingerprint of some plants, typically by gas chromatography, methods capable of quantifying representative terpenes in herbal preparations and dietary supplements with combined high sensitivity and precision, simplicity, and high throughput are still necessary. In this study, we have e…
Fashion-driven Textiles as A Crystal of A New Stream for Stakeholder Capitalism – Amazon's Endeavor
2020
Fashion reflects changes in socio-economic and cultural life which, in turn, changes fashion, and apparel boosts such change. Thus, in response to a shift in people’s preferences from economic functionality to supra-functionality beyond an economic value, the fashion industry has been gaining momentum worldwide. In the digital economy, the fashion industry is in the midst of global dynamic change stimulating volatility, velocity, variety and dynamism, which necessitate a digital solution. Digital business leader Amazon has succeeded in constructing an R&D-driven disruptive businesss model. This can be attributed to a virtuous cycle among user-driven innovation, advancement of the …
Immunodetection of the microvillous cytoskeleton molecules villin and ezrin in the parasitophorous vacuole wall of Cryptosporidium parvum (Protozoa: …
1999
Microvilli - actin - villin - ezrin - Cryptosporidium parvum The sporozoites and merozoites of the Apicomplexan protozoan Cryptosporidium parvum (C. parvum) invade the apical side of enterocytes and induce the formation of a parasitophorous vacuole which stays in the brush border area and disturbs the distribution of microvilli. The vacuole is separated from the apical cytoplasm of the cell by an electron-dense layer of undetermined composition. In order to characterize the enterocyte cytoskeleton changes that occur during C. parvum invasion and development, we used both confocal immunofluorescence and immunoelectron microscopy to examine at the C.parvum-enterocyte interface the distributio…
La maté porque era mía
2003
Ultrafast ionization and rotational dynamics of molecules in strong laser fields
2021
The investigation of ultrafast molecular dynamics is of great importance towards the understanding of a variety of natural phenomena in physical and chemical sciences. With the rapid development of femtosecond laser systems and precision detection technologies, it is possible now to visualize and steer the motion of molecules in matter as well as the ultrafast dynamics of electrons and nuclei in molecules on a microscopic timescale. When a molecule is exposed to a strong laser field, its electrons can be freed or excited, which often triggers a rapid dissociation of the system, in which the released electrons and nuclei exhibit a strong correlation, while the electronic motion on attosecond…
High spatiotemporal resolution in multifocal processing with femtosecond laser pulses.
2006
We report spatial and temporal dispersion compensation for fan-out of femtosecond pulses with a low-frequency diffraction grating by means of a hybrid diffractive-refractive lens triplet. In this way, we achieve a multifocal light structure with nearly diffraction-limited light spots even for 20 fs pulse duration. The spatial chromatic compensation, which drastically reduces the lateral walk-off of the various spectral components, also allows us to improve the available bandwidth at the dispersion-compensated diffraction orders. In fact, the temporal width of the output pulse is essentially limited by the group-delay dispersion term, which is shown to be small. The high spatiotemporal resol…
All-fibered high-quality 1.5–2 THz femtosecond pulse sources
2009
Generation of high-quality ultra-high repetition rate optical pulse trains around 1.55µm has become increasingly interesting for many scientific applications such as optical sampling, ultra-high capacity transmission systems, component testing or nonlinear phenomena studies. Unfortunately, the current bandwidth limitations of optoelectronic devices do not enable the direct generation of pulses with repetition rate higher than 80GHz and a temporal width below a few ps.
Diffractive optics for quasi-direct space-to-time pulse shaping.
2008
The strong chromatic behavior associated with a conventional diffractive lens is fully exploited to propose a novel optical device for pulse shaping in the femtosecond regime. This device consists of two optical elements: a spatially patterned circularly symmetric mask and a kinoform diffractive lens, which are facing each other. The system performs a mapping between the spatial position of the masking function expressed in the squared radial coordinate and the temporal position in the output waveform. This space-to-time conversion occurs at the chromatic focus of the diffractive lens, and makes it possible to tailor the output central wavelength along the axial location of the output point…