Search results for "arco"

A Mediterranean record of Eulalia ornata (Annelida: Phyllodocidae) corroborating its fidelity link with the Sabellaria alveolata-reef habitat

2015

Among marine habitats Sabellaria alveolata -reefs deserve protection since they provide important ecosystem services and positive effects on biodiversity. Several marine species are listed among the S. alveolata -reef associated fauna, but characteristic species were seldom reported. Eulalia ornata (Annelida, Phyllodocidae) might represent an exception, since it appears common/abundant in S. alveolata -reefs of the Eastern Atlantic. The most evident geographical mismatch in the distributions of E. ornata and these biogenic reefs occurs in the Mediterranean Sea, where S. alveolata -reefs are commonly found, but E. ornata was never recorded, whilst E. viridis , a non-Mediterranean species, wa…

IL PARTENOLIDE INDUCE MORTE CELLULARE CASPASI-INDIPENDENTE IN CELLULE DI OSTEOSARCOMA UMANO MG63

2011

Role of sparc and MIR-29B1 in molecular effects induced by win in osteosarcoma MG63 cells

2014

SPARC (Secreted protein acidic and rich in cysteine) is considered as a prototype of matricellular protein due to its structure and the function that it displays in regulating cell/extracellular microenvironment interactions during development and in response to injury. Earlier studies underlined pleiotropic effects of intracellular SPARC on cancer growth and, in some cancer cell lines, identified it as a tumor suppressor protein. Objective This study aimed to evaluate the role of SPARC and its related miRNA in the molecular effects induced by the cannabinoid WIN in osteosarcoma MG63 cells. In these cells WIN is not able to induce cell death but sensitizes cells to TRAIL-mediated apoptotic …

Parthenolide induces caspase-independent cell death in osteosarcoma, melanoma and breast cancer cells through the induction of oxidative stress.

2012

Parthenolide, a sesquiterpene lactone found in European feverfew, is used in traditional medicine for its anti-inflammatory activity. In addition, parthenolide has been considered as a novel and effective anti-tumor agent because it induces cytotoxic effects in several tumor cell lines. Our studies demonstrated that parthenolide exerted strong cytotoxic effects in osteosarcoma MG63 and melanoma SK-Mel28 cells in culture. Staining with Hoechst 33342 revealed in most cells after brief periods of treatments (3-5h) chromatin condensation and fragmentation, while only few cells were PI-positive. Prolonging the treatment (5-14h) PI-positive cells strongly augmented, denouncing the increase of nec…

WIN modulates osteosarcoma MG63 cell migration by inhibiting MMPs activity and adjusting intra- and extra-cellular SPARC differential expression

2014

Invasion of cancer cells into surrounding tissue is an initial step in tumor metastasis. This event, which requires migration of cancer cells and attachment to extracellular matrix (ECM), is regulated by elements of the local microenvironment, including ECM architecture. After having demonstrated the ability of the synthetic cannabinoid WIN55,512 to induce osteosarcoma MG63 cell death (1), we studied the effects of WIN on MG63 cell migration. Wound healing assay was performed to measure the ability of cells to migrate and fill the gap obtained by physical disruption of cell monolayer (2). We observed a significant delay in wound closure in 5 M WIN treated cells compared to untreated cells …

Extracellular Vesicles: Delivery Vehicles of Myokines

2019

Movement and regular physical activity are two important factors that help the human body prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart diseases, hypertension, sarcopenia, cachexia and cancer. During exercise, several tissues release molecules into the blood stream, and are able to mediate beneficial effects throughout the whole body. In particular, contracting skeletal muscle cells have the capacity to communicate with other organs through the release of humoral factors that play an important role in the mechanisms of adaptation to physical exercise. These muscle-derived factors, today recognized as myokines, act as endocrine and paracrine hor…

Guida Geologica del Parco delle Madonie - II edizione

2012

The Impact of Climate, Resource Availability, Natural Disturbances and Human Subsistence Strategies on Sicilian Landscape Dynamics During the Holocene

2022

This paper presents a multidisciplinary summary of the most recent discoveries and hypotheses concerning factors driving the human subsistence economy and landscape shaping in Sicily during the Holocene. A number of scientific papers have recently pointed out the key role played by paleogeography, resource (water, food) availability and natural disturbances (volcanic eruptions, tsunamis) in local human activities. Modern anthropology and archaeology increasingly use biological remains (e.g. soils, bones, wood, plant macroremains, pollen) to better understand how human communities managed to survive and spread. Likewise, refined reconstructions of past human demographic fluxes and socio-econ…

Integrazione fra pianificazione di spazi per giovani e trasporti: un'esemplificazione nell'area urbana di Palermo

2009

FACILITIES FOR YOUNGER PEOPLE AND TRANSPORT INFRASTRUCTURES IN THE URBAN PLANNING PROCESS Public spaces planning for younger people and for "not young" is a main territorial asset and a major structural and strategic task in the whole planning process, both at regional and local level. To understand the relations that may exist between the "social" or "human" assets and the "economic" and "environmental" assets, a new methodology to define strategies and regional issues, is proposed in order to implement services for large areas with mobility in general and public transport and intermodality in particular. Spatial accessibility in " interchange modal nodes " designed as "places to use integ…

Safety verification and non-destructive testing on the masonry della Porta bridge in the Gulf of Castellammare (TP)

2011

I ponti ad arco in muratura rappresentano una parte assai rilevante del patrimonio di opere d’arte stradali e ferroviarie del nostro paese, sia per quanto riguarda la loro consistenza numerica, sia per la qualità del loro inserimento ambientale e l’efficienza statica [1-6]. In questi casi il costo di manutenzione è spesso contenuto e circoscritto alle canalizzazioni delle acque superficiali ed al controllo della vegetazione, che può eventualmente radicarsi sui giunti della muratura in corrispondenza delle spalle o dei cappelli di rostro delle pile. Nei ponti in muratura non ci sono giunti di dilatazione, né apparecchi di appoggio con cerniere o carrelli, come nei ponti metallici e in cement…