Search results for "biosensor"

BIO Bragg gratings on microfibers for label-free biosensing

2021

[EN] Discovering nanoscale phenomena to sense biorecognition events introduces new perspectives to exploit nano science and nanotechnology for bioanalytical purposes. Here we present Bio Bragg Gratings (BBGs), a novel biosensing approach that consists of diffractive structures of protein bioreceptors patterned on the surface of optical waveguides, and tailored to transduce the magnitude of biorecognition assays into the intensity of single peaks in the reflection spectrum. This work addresses the design, fabrication, and optimization of this system by both theoretical and experimental studies to explore the fundamental physicochemical parameters involved. Functional biomolecular gratings ar…

Supramolecular assembly of pyrene-tetrathiafulvalene hybrids on graphene: Structure-property relationships and biosensing activity

2021

Two different molecular receptors (1 and 2) incorporating one and three pyrene units to promote the π–π interaction with the basal plane of graphene are reported. In order to modulate the electronic properties of graphene, the new receptors are endowed with an electron-donor tetrathiafulvalene moiety (exTTF). The resulting non-covalent hybrids have been characterized by different analytical, spectroscopic and microscopic techniques (TGA, Raman, UV-Vis absorption, TEM and XPS), and the supramolecular interaction of the molecular systems with graphene has been investigated by theoretical calculations. The electrochemical behavior of the pyrene-exTTF hybrids onto distinct graphene-based materi…

DNA Sensors for the Detection of Biomolecules and Biochemical Conditions

2017

Desarrollo de Aptazovid: aptasensor piezoeléctrico para la detección de SARS-CoV-2

2021

SARS-CoV-2 ha dado lugar a una pandemia en la que la detección y aislamiento de personas infectadas es clave para luchar contra el virus. La detección puede ser directa o indirecta con diferentes dianas y muestras de partida, aplicando técnicas tan conocidas como la RT-PCR o desarrollando nuevos métodos que integran herramientas como CRISPR, aunque con ciertas limitaciones. Desde hace algún tiempo, los biosensores están en auge y la pandemia ha favorecido la inversión en el desarrollo de tecnologías que superen los inconvenientes de metodologías más tradicionales. En este contexto, como solución surge Aptazovid, un aptasensor piezoeléctrico que detecta directamente la glicoproteína de super…

Novel biosensoric devices based on molecular protein hetero-multilayer films

1997

We have developed a novel concept for the modification of technical surfaces with molecularly well-organized layers of bioorganic components. A molecular construction set has been used to implement this concept which is based on molecularly stratified polyelectrolyte films as a structure decoupling protein layers from solid substrates. Utilizing this technology, one can start from a number of different substrates to obtain the same surface structures, on which protein hetero-multilayer films can be prepared to functionalize the interface for (potentially very different) purposes. We have demonstrated the viability of this concept by constructing a biosensor surface that was characterized by…

Model network architectures in vitro on extracellular recording systems using microcontact printing

2001

A PDMS stamp is used to transfer a synthetic peptide in a given pattern to any suitable surface. Using this method two-dimensional neuronal model networks could be formed on glass substrates as well as on electronic devices and adjusted to the given microelectronic structure. The present work focuses on the mechanism of neurite guidance under simplified in vitro conditions, using in vitro guidance cues and outline the incorporation of these interfacial methods into microelectronic sensor devices.

dsRNA-functionalized multifunctional gamma-Fe2O3 nanocrystals: a tool for targeting cell surface receptors.

2008

Dual-Polarization Interferometry: A Novel Technique To Light up the Nanomolecular World

2015

[EN] The challenging lecture given in 1959 by physicist and Nobel Prize awarded R. P. Feynman: “There's plenty of room at the bottom” is considered to be the starting point for nanotechnology. With this peculiar title, Feynman encouraged researchers to explore beyond the atomic level and predicted exciting new phenomena that might revolutionize science and technology. Among these pioneering researchers are Eric Betzig, Stefan W. Hell and William E. Moerner, who have been awarded with the Nobel Prize in Chemistry 2014 for developing the super-resolved fluorescence microscopy. However, it is important to remark that the exploration of this amazing nanomolecular world began in the early 1980s …

IRiS—Exploring new frontiers in neutron-rich isotopes of the heaviest elements with a new Inelastic Reaction Isotope Separator

2011

Abstract A dedicated Inelastic Reaction Isotope Separator (IRiS) for multi-nucleon transfer products will be designed and installed at GSI. Research at IRiS will focus on the investigation of new neutron-rich isotopes of the heaviest elements, study of which will advance various research fields, such as nuclear chemistry, nuclear and atomic physics, as well as nuclear astrophysics. The scientific motivation for this project and the alternative design options for the separator and its main components are discussed.

Optical and electrochemical DNA nanobiosensors

2011

In the past two decades, nanoscale advanced materials have been explored for biosensing molecules, so new horizons have opened up for identifying and quantifying biomolecules, and possible early diagnosis of diseases. DNA nanobiosensors show promise. This article provides an overview on their optical and electrochemical aspects. We discuss recent progress in this field, describing basic concepts of molecular beacons and quantum dots as optical nano-imaging systems. Also, carbon nanotubes provide a platform for development and advancement of electrochemical DNA nanobiosensors, which are increasingly being implemented as robust tools for detection in biomedical sciences. Refereed/Peer-reviewed