6533b825fe1ef96bd128207c

RESEARCH PRODUCT

Model network architectures in vitro on extracellular recording systems using microcontact printing

Andreas OffenhäusserC. SprösslerMorgan DenyerA. MaelickeWolfgang KnollM. SchollKen NakajimaMichael Krause

subject

Materials sciencebusiness.industryMechanical EngineeringMetals and AlloysPDMS stampNanotechnologyCondensed Matter PhysicsElectronic Optical and Magnetic MaterialsMechanics of MaterialsMicrocontact printingMaterials ChemistryMicroelectronicsModel networkElectronicsbusinessBiosensor

description

A PDMS stamp is used to transfer a synthetic peptide in a given pattern to any suitable surface. Using this method two-dimensional neuronal model networks could be formed on glass substrates as well as on electronic devices and adjusted to the given microelectronic structure. The present work focuses on the mechanism of neurite guidance under simplified in vitro conditions, using in vitro guidance cues and outline the incorporation of these interfacial methods into microelectronic sensor devices.

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