Search results for "cellar"
showing 10 items of 230 documents
Opioid analgetics retention–pharmacologic activity models using biopartitioning micellar chromatography
2002
Opioids are drugs used in medicine for pain control. In this paper, retention-pharmacokinetics and retention-pharmacodynamics relationships of opioids are proposed and statistically validated. These models are based on the compound retention in the biopartitioning micellar chromatography system (BMC), a new methodology which has successfully been used to develop QRAR models for many other families of compounds. The obtained results are compared to the traditional QSAR models using lipophilicity data. The adequacy of QRAR models is due to the fact that the characteristics of the compounds such as the hydrophobicity, electronic charge and steric effects determine both their retention in BMC a…
Reliability of the capacity factor at zero micellar concentration and the solute-micelle association constant estimates by micellar liquid chromatogr…
1997
In micellar liquid chromatography, MLC, the hydrophobicity of a compound is the predominant effect on its retention and interaction with micelles. The capacity factors at zero micellar concentration, k(m), and the solute-micelle association constants, KAM- have recently been used as the hydrophobicity index of compounds and are important in QSAR studies. These parameters could be estimated (by regression) from the (k,[M]) data, where k is the capacity factor and [M] the surfactant concentration minus the critical micelle concentration. km and KAM are usually obtained from the intercept and slope, respectively, of the plot 1/k vs. [M]. In spite of the general use of this equation, the reliab…
Modeling the chiral resolution ability of highly sulfated β-cyclodextrin for basic compounds in electrokinetic chromatography
2013
Abstract Despite the fact that extensive research in the field of enantioseparations by capillary electrophoresis has been carried out, it is difficult to predict whether a concrete chiral selector would be useful for the separation of a racemic compound. Hence, several experimental effort is necessary to test the abilities of individual chiral selectors, usually by trial and error procedures. Thus, the enantioseparation of a new racemate becomes a time- and money-consuming task. In this work, the ability of highly sulfated β-cyclodextrin (HS-β-CD) as chiral selector in electrokinetic chromatography (EKC) is modeled for the first time, using exclusively directly-available structural data of…
Enantioresolution in electrokinetic chromatography-complete filling technique using sulfated gamma-cyclodextrin. Software-free topological anticipati…
2016
Few papers have tried to predict the resolution ability of chiral selectors in capillary electrophoresis for the separation of the enantiomers of chiral compounds. In a previous work, we have used molecular information available on-line to establish enantioresolution levels of basic compounds using highly sulfated β-CD (HS-β-CD) as chiral selector in electrokinetic chromatography-complete filling technique (EKC-CFT). The present study is a continuation of this previous work, introducing some novelties. In this work, the ability of sulfated γ-cyclodextrin (S-γ-CD) as chiral selector in EKC-CFT is modelled for the first time. Thirty-three structurally unrelated cationic and neutral compounds …
Potential of human serum albumin as chiral selector of basic drugs in affinity electrokinetic chromatography-partial filling technique
2006
The enantiomeric resolution of compounds using HSA by means of affinity EKC (AEKC)-partial filling technique is the result of a delicate balance between different experimental variables such as protein concentration, running pH (background electrophoretic buffer (BGE), protein, and compound solutions), and plug length. In this paper, the possibility of using HSA as chiral selector for enantioseparation of 28 basic drugs using this methodology is studied. The effect of the physicochemical parameters, the structural properties of compounds, and compound-HSA protein binding percentages over their chiral resolution with HSA is outlined. Based on the results obtained, a decision tree is proposed…
Development of predictive retention-activity relationship models of tricyclic antidepressants by micellar liquid chromatography.
1999
The distribution of tricyclic antidepressants from plasma to brain, where these drugs exert their main clinical action, and other organs is related to transport events across the cell membranes of the different tissues. It could be expected that all the molecular features that condition the transport processes (mainly hydrophobicity and molar total charge) also control the pharmacokinetic and biochemical behavior. Micellar liquid chromatography (MLC) has been proposed to emulate in vitro the partitioning process in the biomembranes. The use of micellar solutions of Brij35 as mobile phases in reversed-phase liquid chromatography has proven to be valid to predict the biological activities of …
Fruit quality evolution of different olive table cultivars during fermentation.
2008
È possibile il biologico per le olive da mensa?
2017
La frontiera dell’olivicoltura biologica da mensa passa attraverso il controllo della mosca delle olive in aree pandacie a forte pressione del dittero. In queste aree è di grande ausilio l’irrigazione, che facendo raggiungere prima la pezzatura desiderata, consente di sfuggire in parte alle più dannose infestazioni d’inizio autunno; in assenza d’irrigazione, spesso le drupe, all’arrivo delle piogge, aumentano in volume insieme alle infestazioni. I mezzi di controllo suggeriti sono quasi totalmente volti a evitare l’attacco, mediante l’uccisione degli adulti (catture massali o “attract and kill”) o la repellenza (argille e composti del rame); se si esclude l’uccisione delle larve di prima …
Dialoghi tra antico e contemporaneo. Dal Bouleuterion greco alla grande Barricaia di Rocca di Frassinello
2021
La cantina Rocca di Frassinello, progettata da Renzo Piano nel cuore della Maremma Toscana, costituisce uno dei massimi esempi di come la contemporaneità, nelle sue forme più essenziali, possa fondersi perfettamente con il paesaggio naturale circostante senza alterarne gli equilibri e la storia ma anzi valorizzandolo in maniera magistrale. Il centro pulsante della cantina è la grande barricaia ipogea nella quale riposano fino a 2.500 barriques di rovere francese disposte su gradinate digradanti. La particolare configurazione a gradoni della barricaia sembra richiamare l'impianto planimetrico di una forma architettonica legata all'antica Grecia, il bouleuterion. Un'iscrizione da Teos attesta…
Malattia celiaca e malocclusione
2010
La celiachia è una malattia autoimmune, causata da una intolleranza permanente al glutine, che si manifesta in individui geneticamente predisposti, causando enteropatia. In questi individui una prolungata esposizione al glutine aumenta il rischio di sviluppare altre patologie, che possono influire nello sviluppo della dentatura e della mucosa orale. Le manifestazioni cliniche sono diverse e atipiche.I pazienti con celiachia possono soffrire di ipoplasia dello smalto, maggiore prevalenza della carie dentale, eruzione ritardata dei denti e riduzione della crescita del mascellare inferiore. Questi fattori predispongono ad una malocclusione.