Search results for "cellular"
showing 10 items of 6449 documents
TGFβ-activated kinase 1 (TAK1) is activated and predicts prognosis in hepatocellular carcinoma
2020
Heterogeneous Pattern of Differentiation With BCAS1/NABC1 Expression in a Case of Oligodendroglioma
2020
The dynamics over the next few years of the Spanish mobile telecommunications market share: a mathematical modelling approach
2013
Taking into account available data from 2002 to 2009 about the market share percentages of the Spanish mobile telecommunications service providers, a dynamic diffusion model to study the evolution of the clients’ change between the different companies during the period 2010–2016 is proposed. The constructed model provides a tool for forecasting short-term trends about the customers’ preferences with respect to mobile network operators taking into account both, autonomous decisions due to direct marketing and advertising strategies, and also decisions adopted through interaction via social influence. The model can provide insights to companies for designing strategies in order to gain market…
A model study for the progressive disruption of CA1 firing properties during Alzheimer’s disease
2011
Several independent studies show that β-Amyloid (Aβ) peptides accumulation, one of the characteristic hallmark of Alzheimer’s Disease (AD), can affect the normal neuronal activity in different ways causing an increase or a decrease in neuronal membrane excitability. For example, experimental evidence for a negative impact on neuronal membrane in animal models of AD has been obtained in dual patch recordings in rat hippocampal tissue slices, in which Aβ blocked K channels in pyramidal cell dendrites, causing an increase in dendritic membrane excitability. The resulting increased Ca2+ influx and excitoxicity may lead to dendritic degeneration. However, further experimental evidence suggests t…
Immune pathogenesis of hepatitis A
1992
In an effort to elucidate the mechanism of liver damage resulting from Hepatitis A virus (HAV) infection, we have studied infected skin fibroblasts and autologous lymphocytes from HAV patients. We report here that HLA-restricted virus-specific T cells play an essential role in HAV-related hepatocellular injury.
Dauer epileptischer Anfälle während selektiver pharyngealer Hirnkühlung / Duration of induced seizures during selective pharyngeal brain cooling
2004
Whole body hypothermia can be used to treat the injured brain (e.g. after hypoxic events). Side effects include hemodynamic instability, coagulopathy and infection. Because of these side effects it appears reasonable to cool the brain selectively (selective brain cooling, SBC) without changing the core temperature. A new animal model was used to demonstrate SBC from the pharynx and to examine effects of SBC on the duration of pharmacologically induced seizure activity. Sprague-Dawley rats (n=18, 12 successful experiments) were sedated and mechanically ventilated. Invasive blood pressure monitoring was instituted and blood gases were drawn to evaluate the arterial blood gas status. Electrica…
Morphological similarities between DBM and an economic geography model of city growth
2009
International audience; An urban microeconomic model of households evolving in a 2Dcellular automata allows to simulate the growth of a metropolitan area whereland is devoted to housing, road network and agricultural/green areas. Thissystem is self-organised: based on individualistic decisions of economic agentswho compete on the land market, the model generates a metropolitan area withhouses, roads, and agriculture. Several simulation are performed. The resultsshow strong similarities with physical Dieletric breackdown models (DBM). Inparticular, phase transitions in the urban morphology occur when a controlparameter reaches critical values. Population density in our model and theelectric …
Editorial: Physiology and Pathophysiology of Heat Shock Protein 60
2020
MiR-221 promotes stemness of breast cancer cells by targeting DNMT3b
2016
// Giuseppina Roscigno 1, 2 , Cristina Quintavalle 1, 2 , Elvira Donnarumma 3 , Ilaria Puoti 1 , Angel Diaz-Lagares 4 , Margherita Iaboni 1 , Danilo Fiore 1 , Valentina Russo 1 , Matilde Todaro 5 , Giulia Romano 6 , Renato Thomas 7 , Giuseppina Cortino 7 , Miriam Gaggianesi 5 , Manel Esteller 4 , Carlo M. Croce 6 , Gerolama Condorelli 1, 2 1 Department of Molecular Medicine and Medical Biotechnology, “Federico II” University of Naples, Naples, Italy 2 IEOS-CNR, Naples, Italy 3 IRCCS-SDN, Naples, Italy 4 Epigenetic and Cancer Biology Program (PEBC) IDIBELL, Hospital Duran I Reynals, Barcelona, Spain 5 Department of Surgical and Oncological Sciences, Cellular and Molecular Pathophysiology Lab…
Dissecting the Mechanism of Action of Spiperone—A Candidate for Drug Repurposing for Colorectal Cancer
2022
Approximately 50% of colorectal cancer (CRC) patients still die from recurrence and metastatic disease, highlighting the need for novel therapeutic strategies. Drug repurposing is attracting increasing attention because, compared to traditional de novo drug discovery processes, it may reduce drug development periods and costs. Epidemiological and preclinical evidence support the antitumor activity of antipsychotic drugs. Herein, we dissect the mechanism of action of the typical antipsychotic spiperone in CRC. Spiperone can reduce the clonogenic potential of stem-like CRC cells (CRC-SCs) and induce cell cycle arrest and apoptosis, in both differentiated and CRC-SCs, at clinically relevant co…