Search results for "chronic"

ANTIAGING STRATEGIES

2010

Positioning the principles of precision medicine in care pathways for allergic rhinitis and chronic rhinosinusitis – A EUFOREA-ARIA-EPOS-AIRWAYS IC…

2017

Precision medicine (PM) is increasingly recognized as the way forward for optimizing patient care. Introduced in the field of oncology, it is now considered of major interest in other medical domains like allergy and chronic airway diseases, which face an urgent need to improve the level of disease control, enhance patient satisfaction and increase effectiveness of preventive interventions. The combination of personalized care, prediction of treatment success, prevention of disease and patient participation in the elaboration of the treatment plan is expected to substantially improve the therapeutic approach for individuals suffering from chronic disabling conditions. Given the emerging dat…

Chronic Total Coronary Artery Occlusion Recanalisation with Percutaneous Coronary Intervention — Single Centre 10-Year Experience

2018

Abstract Coronary artery chronic total occlusions (CTO) are common — approximately one-third of patients with significant coronary artery disease on angiography have at least 1 CTO. Invasive treatment of these lesions still remain a major challenge for interventional cardiology due to their complexity. Historically, success rates have improved to about 60–70% by using only the traditional antegrade approach. The results have dramatically improved during the last decade after more widespread application of new retrograde techniques. The aim of our study was to review and analyse single hospital experience in CTO invasive treatment and to evaluate the long-term results. A total of 519 patient…

¿Quién tiene miedo del pasado? La relación con la historia de la demo-etno-antropología italiana entre los siglos xix y xx

2019

The construction of the past and its periodic reaffirmation are fundamental moments of the construction of identity, both individual and collective, and are, therefore, the object of more or less conscious decisions and manipulations by groups and individuals. It is only through the diachronic analysis of cultural responses to human problems that certain spatial and temporal continuities of ritual forms, beliefs and symbols that justify it are clarified; it is not only at the level of the mere succession of phenomena, because of the signifiers, nor of the only sociological analysis that they possess and the attention of those who seek the reasons for being in the future must be concentrated…

Conditioned Pain Modulation Is Not Impaired in Individuals with Frozen Shoulder: A Case-Control Study

2021

Frozen shoulder (FS) is a poorly understood condition resulting in substantial shoulder pain and mobility deficits. The mechanisms behind FS are not yet fully understood, but, similar to other persistent pain states, central pain mechanisms may contribute to ongoing symptoms in this population. The objective of this research was to investigate conditioned pain modulation (CPM) in people with FS compared with pain-free individuals. A total of 64 individuals with FS and 64 healthy volunteers participated in this cross-sectional study. CPM was assessed by using the pressure pain threshold (PPT) and an occlusion cuff (tourniquet test) as the test and conditioning stimulus, respectively. The abs…

The battle of Konotop as recorded in Cossack chronicles

2016

The battle of Konotop on June 28, 1659 has gained particular resonance as a historical event in the independent Ukraine since the historical narrative has begun to be re-examined and ‘reconstructed’ in a new political climate. This has been possible since the theme of historical confrontation between Ukraine and Russia became free for discussion after many centuries of ta- boo. Interest in the subject has grown and progress in historiography may be acknowledged thanks to several new works published in recent years: these have provided a well-grounded picture of the event, while also raising a number of questions that still need to be investigated for a correct inter- pretation1. The chronic…

NFATc1 Is Transcriptionally Activated in Chronic Lymphocytic Leukemia (CLL) By Promotor DNA-Hypomethylation Which Correlates with in-Vitro Vulnerabil…

2014

Abstract Chronic lymphocytic leukemia (CLL), the most frequent adult leukemia in Western countries, is characterized by progressive accumulation of mature, monoclonal B lymphocytes in blood, bone marrow, and lymphoid tissues. In the pathogenesis and treatment of CLL, B cell receptor (BCR) signaling plays a crucial role, and aberrations in downstream pathways that become activated in CLL need to be better defined. One downstream target of BCR signaling is NFATc1, a transcription factor with a high oncogenic and transforming potential. Employing a genome-wide comparative DNA methylation analysis the NFATc1 5’ region was identified to be DNA hypomethylated in CLL patient samples. The pilot ser…

Ecotoxicological studies with the freshwater rotifer Brachionus calyciflorus II. An assessment of the chronic toxicity of lindane and 3,4-dichloroani…

1993

The effects of chronic exposure of the freshwater rotifer Brachionus calyciflorus to the toxicants lindane and 3,4-dichloroaniline (DCA), were evaluated. The parameters used to determine the toxicity on these compounds were the age-specific and fertility, and the demographic parameters: intrinsic rate of natural increase (r), generation time (T), net reproductive rate (Ro), reproductive value (Vx) and life expectancy (eo). All the demographic parameters studied decreased with increasing toxicant concentrations. The use of life tables techniques with B. calyciflorus as a test method for the determination of chronic toxicity of xenobiotics is discussed.

Pityriasis lichenoides chronica associated with herpes simplex virus type 2.

2012

Introduction. Pityriasis lichenoides is a rare, acquired spectrum of skin conditions of an unknown etiology.Case Report. A 28-year-old man presented with recurrent outbreaks of herpes simplex virus associated with the onset of red-to-brown maculopapules located predominantly in trunk in each recurrence. Positive serologies to herpes simplex virus type 2 were detected. Histopathological examination of one of the lesions was consistent with a diagnosis of pityriasis lichenoides chronica.Discussion. Pityriasis lichenoides is a rare cutaneous entity of an unknown cause which includes different clinical presentations. A number of infectious agents have been implicated based on the clustering of …

Assessment of nursing and midwifery students’ knowledge of treatment of diabetic foot syndrome using Lucilia servicata larvae

2021

Background. Diabetes mellitus is one of the most common chronic diseases, and in recent years its prevalence has been systematically increasing. Untreated or ineffectively treated diabetes leads to the development of many complications. Among these that can significantly affect the quality of life is diabetic foot syndrome (DFS). Larvotherapy is a therapeutic method of treating wounds arising during the course of DFS. Aim of the study. The main objective of this study was to assess the level of knowledge of nursing and midwifery students on the treatment of DFS using Lucilia sericata larvae. Material and Methods. This study is a cross-sectional, observational study in which 202 nursing and …