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showing 10 items of 1682 documents

Yield, pomological characteristics, bioactive compounds and antioxidant activity of Annona cherimola Mill. grown in mediterranean climate

2019

The agronomic and qualitative responses of the cherimoya (Annona cherimola Mill.) fruit grown in Mediterranean climate are not properly studied. Fruits of Fino de Jete, the most diffused worldwide cultivar of cherimoya, and Torre 1 a new genotype obtained by breeding program in Sicily, Italy, were collected at commercial ripening and subjected to productive (yield efficiency, number of fruits, crop load), analytical (fruit weight, transversal diameter, longitudinal diameter, total soluble solid content, titratable acidity, seed weight, seed number, peel and pulp weight, pulp/seed ratio and colorimetric analysis), bioactive compound content (total antioxidant activity, Phenolic and Carotenoi…

Annona cherimolabioactive compoundslocal productionfood and beveragesphysico-chemical propertieslcsh:S1-972physico-chemical propertieyield componentssensory analysisSettore AGR/03 - Arboricoltura Generale E Coltivazioni Arboreeyield componentSettore BIO/10 - Biochimicalcsh:Agriculture (General)bioactive compoundAIMS Agriculture and Food
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Chemical composition of the essential oil from Thapsia garganica L. (Apiaceae) grown wild in Sicily and its antimicrobial activity.

2015

In this study, the chemical composition of the essential oil from flowers and leaves of Thapsia garganica L. collected in Sicily was evaluated by GC and GC-MS. The main components of T. garganica flower oil (T.f.) were chamazulene (58.3%), humulene oxide II (9.0%), tricosane (8.2%) and pentacosane (8.2%). Also the oil from leaves (T.l.) was characterised by high content of chamazulene (49.2%). Other abundant metabolites were 1,4-dimethylazulene (18.5%), (E)-phytol (6.3%) and neophytadiene (5.1%). The comparison with other studied oils of genus Thapsia is discussed. Antimicrobial activity against several micro-organisms, including some ones infesting historical art craft, was also determined.

Anti-Infective AgentAntifungal Agentshumulene oxide IIPlant Science01 natural sciencesThapsia garganicaBiochemistrylaw.inventionAnalytical Chemistrychemistry.chemical_compoundAnti-Infective AgentslawAntifungal AgentSettore BIO/15 - Biologia FarmaceuticaChemical compositionSicilyThapsia1-dimethylazulenebiologyHumuleneChemistryMicrobial Sensitivity TestchamazuleneAntimicrobialThapsia (plant)Anti-Bacterial Agentsvolatile componentFlowerPlant LeaveThapsia garganicaFlowersMicrobial Sensitivity TestsGas Chromatography-Mass SpectrometryBotanyAnti-Bacterial AgentOils VolatileEssential oilApiaceaeantimicrobial activityBacteria010405 organic chemistryChamazuleneOrganic ChemistryFungiSettore CHIM/06 - Chimica Organicabiology.organism_classification0104 chemical sciencesPlant Leaves010404 medicinal & biomolecular chemistryApiaceaeNatural product research
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Artemisia herba-alba essential oil from Buseirah (South Jordan): Chemical characterization and assessment of safe antifungal and anti-inflammatory do…

2015

Abstract Ethnopharmacologic relevance Artemisia herba-alba Asso (“desert wormwood” in English; “armoise blanche” in French; “shaih” in Arabic), is a medicinal and strongly aromatic plant widely used in traditional medicine by many cultures since ancient times. It is used to treat inflammatory disorders (colds, coughing, bronchitis, diarrhea), infectious diseases (skin diseases, scabies, syphilis) and others (diabetes, neuralgias). In Jordanian traditional medicine, this plant is used as antiseptic and against skin diseases, scabies, syphilis, fever as well as menstrual and nervous disorders. Aim of the study Considering the traditional medicinal uses and the lack of scientific studies addre…

Antifungal AgentsCell Survivalmedicine.drug_classAnti-Inflammatory AgentsBiologyPharmacologyAnti-inflammatorylaw.inventionMiceMinimum inhibitory concentrationCamphorchemistry.chemical_compoundlawDrug DiscoveryOils VolatilemedicineAnimalsPlant OilsViability assayCandida albicansEssential oilPharmacologyJordanDose-Response Relationship DrugTraditional medicineArtemisia herba-albaPlant Components Aerialbiology.organism_classificationArtemisiachemistryArtemisiaJournal of Ethnopharmacology
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Bioactive aristolactams from Piper umbellatum.

2007

Four alkaloids named piperumbellactams A-D (1-4) were isolated from branches of Piper umbellatum together with known N-hydroxyaristolam II (5), N-p-coumaroyl tyramine (6), 4-nerolidylcatechol (7), N-trans-feruloyltyramine, E-3-(3,4-dihydroxyphenyl)-N-2-[4-hydroxyphenylethyl]-2-propenamide, beta-amyrin, friedelin, apigenin 8-C-neohesperidoside, acacetin 6-C-beta-d-glucopyranoside, beta-sitosterol, its 3-O-beta-d-glucopyranoside and its 3-O-beta-d-[6'-dodecanoyl]-glucopyranoside. Glycosidase inhibition, antioxidant and antifungal activities of these compounds were evaluated. Compounds 1-3 showed moderate alpha-glucosidase enzyme inhibition with IC50 values 98.07+/-0.44, 43.80+/-0.56 and 29.64…

Antifungal AgentsLactamsStereochemistryDPPHFriedelinPlant ScienceHorticultureBiochemistryHeterocyclic Compounds 4 or More Ringschemistry.chemical_compoundAlkaloidsMolecular BiologyPiperAcacetinbiologyMolecular StructurePlant ExtractsAlkaloidGeneral MedicineFree Radical ScavengersTyraminePiperaceaePlant Components Aerialbiology.organism_classificationchemistryApigeninPiperPhytochemistry
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Characterization of the interaction of the antifungal and cytotoxic cyclic glycolipopeptide hassallidin with sterol-containing lipid membranes.

2019

Hassallidins are cyclic glycolipopeptides produced by cyanobacteria and other prokaryotes. The hassallidin structure consists of a peptide ring of eight amino acids where a fatty acid chain, additional amino acids, and sugar moieties are attached. Hassallidins show antifungal activity against several opportunistic human pathogenic fungi, but does not harbor antibacterial effects. However, they have not been studied on mammalian cells, and the mechanism of action is unknown. We purified hassallidin D from cultured cyanobacterium Anabaena sp. UHCC 0258 and characterized its effect on mammalian and fungal cells. Ultrastructural analysis showed that hassallidin D disrupts cell membranes, causin…

Antifungal AgentskolesteroliPeptideLipopeptide01 natural sciencesBiochemistrychemistry.chemical_compoundSTRUCTURE ELUCIDATIONCandida albicansMARINE CYANOBACTERIAmammalian cellsmembrane1183 Plant biology microbiology virologychemistry.chemical_classification0303 health sciencesCell DeathMembraneGlycopeptidesLipopeptideHERBICOLIN-ADEHYDROPEPTIDE LACTONEAmino acidSterolsCholesterolMembraneBiochemistrysolunsalpaajatMitochondrial Membranesmedicine.symptomBacterial outer membraneBiophysicsmechanismAntineoplastic Agentssaponin digitoninMolecular dynamicsCyanobacteriaITURIN-A03 medical and health sciencesLipopeptidesMembrane LipidsNATURAL-PRODUCTSCell Line TumormedicineHumansPropidium iodidesyanobakteerit030304 developmental biologyantimikrobiset yhdisteet010405 organic chemistryMAJOR COMPONENTCell BiologyluonnonaineetAnabaenaSterol0104 chemical sciencesMechanism of actionchemistrylipopeptidepeptiditMOLECULAR-DYNAMICS1182 Biochemistry cell and molecular biologyDrug Screening Assays AntitumorGlycolipidsBiochimica et biophysica acta. Biomembranes
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Chemical composition of essential oils of Anthemis secundiramea Biv. subsp. secundiramea (Asteraceae) collected wild in Sicily and their activity on …

2016

In the present study, the chemical composition of the essential oil from the aerial parts of Anthemis secundiramea Biv. subsp. secundiramea L. collected in Sicily was evaluated by GC and gas chromatography–mass spectrometry. The main components of A. secundiramea were (Z)-lyratyl acetate (14.6%), (Z)-chrysanthenyl acetate (9.9%), (Z)-chrysanthenol (8.7%) and (E)-chrysanthenyl acetate (7.7%). The comparing with other studied oils of genus Anthemis belonging to the same clade is discussed. Antibacterial and antifungal activities against some micro-organisms infesting historical art craft, were also determined.

AntifungalAntifungal Agentsmedicine.drug_classPlant compositionchrysanthenyl derivatives antibacterial and antifungal activityPlant ScienceAsteraceaeBiology01 natural sciencesBiochemistryGas Chromatography-Mass SpectrometryAnalytical Chemistrylaw.inventionBridged Bicyclo CompoundsGenuslawBotanyOils VolatilemedicinePlant OilsAnthemisSettore BIO/15 - Biologia FarmaceuticaSicilyChemical compositionEssential oilAnthemis secundiramea010405 organic chemistryOrganic ChemistrySettore CHIM/06 - Chimica OrganicaAsteraceaebiology.organism_classificationAnti-Bacterial Agents0104 chemical sciences(Z)-lyratyl acetatevolatile component010404 medicinal & biomolecular chemistryAnthemis secundiramea Biv. subsp. secundirameaMonoterpenesAnthemisArtNatural Product Research
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Antimicrobial and antiproliferative activity of Peucedanum nebrodense (Guss.) Strohl.

2003

Abstract Acetone extract of Peucedanum nebrodense (Guss.) Strohl., a rare endemic species from the Madonie mountains (Sicily), was tested in vitro for its antimicrobial activity against bacterial reference strains and antiproliferative activity against K562 (human chronic myelogenous leukemia), HL-60 (human leukemia) and L1210 (murine leukemia) cell lines. The acetone extract showed antiproliferative IC 50 values in the range of 14–0.27 μg/ml.

Antineoplastic AgentsHL-60 CellsBiologyPlant RootsAcetoneMiceAnti-Infective Agentshemic and lymphatic diseasesDrug DiscoverymedicinePeucedanum nebrodenseCoumarins Antimicrobial Antiproliferative activityAnimalsHumansLeukemia L1210PharmacologyTraditional medicinePlant ExtractsBiological activityPlant Components AerialAntimicrobialmedicine.diseaseIn vitroLeukemiaCell cultureK562 CellsPeucedanum nebrodenseCell DivisionChronic myelogenous leukemiaK562 cellsApiaceaeJournal of ethnopharmacology
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Tiliroside and gnaphaliin inhibit human low density lipoprotein oxidation.

2004

Two flavonoids, gnaphaliin and tiliroside, isolated from Helichrysum italicum, were studied in vitro for their capacity to inhibit Cu(2+)-induced human low density lipoprotein (LDL) and diluted plasma oxidation. LDL oxidation was monitored by conjugated diene, thiobarbituric acid-reactive substances (TBARS) formation and electrophoretic mobility on agarose gel. Gnaphaliin and tiliroside increased the lag-phase for diene conjugate production in a dose-dependent manner. The reduction of TBARS production confirmed the antioxidant activity of gnaphaliin and tiliroside with 50% inhibitory concentration (IC(50)) values of 8.0+/-3.9 microM and 7.0+/-2.6 microM respectively. Furthermore, the flavon…

AntioxidantCopper Sulfatemedicine.medical_treatmentProbucolPharmacognosyThiobarbituric Acid Reactive SubstancesLipid peroxidationchemistry.chemical_compoundInhibitory Concentration 50Drug DiscoverymedicineTBARSHumansBenzopyransIC50PharmacologyFlavonoidsHelichrysumChromatographyPlant ExtractsGeneral MedicineCholesterol LDLPlant Components AerialFlavonesLipoproteins LDLBiochemistrychemistryLow-density lipoproteinAgaroseLipid Peroxidationmedicine.drugPhytotherapyFitoterapia
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UV-Induced Changes of Active Components and Antioxidant Activity in Postharvest Pigeon Pea [Cajanus cajan (L.) Millsp.] Leaves

2013

In this study, the effect of UV irradiation (UV-A, UV-B, and UV-C) on phytochemicals, total phenolics, and antioxidant activity of postharvest pigeon pea leaves was evaluated. The response of pigeon pea leaves to UV irradiation was phytochemical specific. UV-B and UV-C induced higher levels of phytochemicals, total phenolics, and antioxidant activity in pigeon pea leaves compared with UV-A. Furthermore, UV-B irradiation proved to possess a long-lasting effect on the levels of phenolics and antioxidant activity. After adapting for 48 h at 4 °C following 4 h UV-B irradiation, total phenolics and antioxidant activity were approximately 1.5-fold and 2.2-fold increased from 39.4 mg GAE/g DM and …

AntioxidantbiologyPlant ExtractsChemistrymedicine.medical_treatmentActive componentsfood and beveragesGeneral Chemistrybiology.organism_classificationAntioxidantsPlant LeavesCajanusCajanusPhenolsPhytochemicalBotanymedicinePostharvestFood scienceGeneral Agricultural and Biological SciencesJournal of Agricultural and Food Chemistry
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Prophylaxis of Non-communicable Diseases: Why fruits and vegetables may be better chemopreventive agents than dietary supplements based on isolated p…

2019

The World Health Organization (WHO) report from 2014 documented that non-communicable socalled civilization diseases such as cardiovascular disease, chronic respiratory diseases, cancer or type 2 diabetes are responsible for over 50% of all premature deaths in the world. Research carried out over the past 20 years has provided data suggesting that diet is an essential factor influencing the risk of development of these diseases. The increasing knowledge on chemopreventive properties of certain food ingredients, in particular, those of plant origin, opened the discussion on the possibility to use edible plants or their active components in the prevention of these chronic diseases. Health-pro…

Antioxidants; Bioactive phytochemicals; Cancer; Chemoprevention; Civilization diseases; Flavonoids; Food synergyantioxidantPhytochemicalsRespiratory Tract DiseasesActive componentsDiseaseChemopreventionWorld healthAntioxidants03 medical and health sciencesbioactive phytochemical0302 clinical medicineFunctional foodNeoplasmsVegetablesDrug DiscoveryHumansMedicinecivilization diseaseflavonoidNoncommunicable Diseases030304 developmental biologyCancer2. Zero hungerPharmacologyFlavonoids0303 health sciencesTraditional medicineFood synergyHuman organismbusiness.industryBioactive phytochemicalsDiet3. Good healthDiabetes Mellitus Type 2Cardiovascular DiseasesFruit030220 oncology & carcinogenesisFruits and vegetablesDietary SupplementsEdible plantsCivilization diseasesCritical assessmentbusiness
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