Search results for "context"
showing 10 items of 6304 documents
Palliative sedation in patients with advanced cancer followed at home: A systematic review
2011
Abstract Context Patients with advanced cancer who are near the end of life may experience intolerable suffering refractory to targeted palliative therapies. Palliative sedation (PS) is considered to be an effective treatment modality for these refractory symptoms when aggressive efforts fail to provide relief. Objectives The aim of this study was to systematically review articles regarding PS performed at home in patients with intractable symptoms. Methods Literature databases searched included MedLine, PubMed, and EMBASE. The text words and MeSH/EMTREE terms "home care" and "sedation" were used for electronic database searches. Results Six articles met the inclusion criteria for research …
Mini-Review: Two Brothers in Crime – The Interplay of TRESK and TREK in Human Diseases
2021
Abstract TWIK-related spinal cord potassium (TRESK) and TWIK-related potassium (TREK) channels are both subfamilies of the two-pore domain potassium (K2P) channel group. Despite major structural, pharmacological, as well as biophysical differences, emerging data suggest that channels of these two subfamilies are functionally more closely related than previously assumed. Recent studies, for instance, indicate an assembling of TRESK and TREK subunits, leading to the formation of heterodimeric channels with different functional properties compared to homodimeric ones. Formation of tandems consisting of TRESK and TREK subunits might thus multiply the functional diversity of both TRESK and TREK …
Thyroïdites : où en est-on en 2019 ?
2020
Thyroiditis is a frequent and mostly benign disease that can sometimes disrupt the thyroid balance. Their diagnosis, as well as their aetiology, is a necessary step in the management of the patients. Painful thyroiditis includes acute thyroiditis of infectious origin and subacute thyroiditis. The first one can be treated by antibiotics or antifungals depending on the germ found. The second one will be treated with non-steroidal anti-inflammatory drugs or corticosteroids. In cases of Hashimoto's thyroiditis with overt hypothyroidism, replacement therapy with L-thyroxine will be adapted to the TSH level. As amiodarone treatment provides dysthyroidism, the thyroid status should be monitored re…
Mapping and quantification of cryptochrome expression in the brain of the pea aphid Acyrthosiphon pisum.
2021
Aphids are paradigmatic photoperiodic animals often used to study the role of the circadian clock in the seasonal response. Previously, we described some elements of the circadian clock core (genes period and timeless) and output (melatonin, AANATs and PTTH) that could have a role in the regulation of the aphid seasonal response. More recently we identified two opsins (C-ops and SWO4) as candidate input photoperiodic receptors. In the present report, we focus on the study of cryptochromes (cry) as photoreceptors of the circadian clock and discuss their involvement in the seasonal response. We analyze the expression of cry1 and cry2 genes in a circadian and seasonal context, and map their ex…
Prolactin supplementation to culture medium improves beta-cell survival
2010
OBJECTIVES.: Recent studies demonstrated that prolactin (PRL) has beneficial effects on β cells for islet transplantation. We examined the effect of human recombinant PRL (rhPRL) supplementation to the culture media to determine its potential use in the context of clinical islet transplantation. MATERIALS AND METHODS.: Each human islet isolated from 14 deceased multiorgan donors was cultured in Miami modified media-1 supplemented with or without rhPRL (500 μg/L) for 48 hr. β-Cell survival and proliferation (BrdU and Ki-67) were determined by laser scanning cytometry. The cytoprotective effects of rhPRL against noxious stimuli were assessed by flow cytometry (tetramethylrhodamine ethyl ester…
Inhibition of TSH/IGF-1 Receptor Crosstalk by Teprotumumab as a Treatment Modality of Thyroid Eye Disease
2021
Abstract Context We previously presented evidence that TSH receptor (TSHR)-stimulating autoantibodies (TSAbs) bind to and activate TSHRs but do not bind to IGF1 receptors (IGF1Rs). Nevertheless, we showed that IGF1Rs were involved in thyroid eye disease (TED) pathogenesis because TSAbs activated crosstalk between TSHR and IGF1R. Teprotumumab, originally generated to inhibit IGF1 binding to IGF1R, was recently approved for the treatment of TED (Tepezza). Objective To investigate the role of TSHR/IGF1R crosstalk in teprotumumab treatment of TED. Design We used orbital fibroblasts from patients with TED (TEDOFs) and measured stimulated hyaluronan (HA) secretion as a measure of orbital fibrobla…
The level of context dependence of engagement markers in Peninsular Spanish and US business websites
2019
This paper examines the impact of Spaniards’ and North-Americans’ level of context dependence (Hall, 1976) on the engagement markers (Hyland & Tse, 2004) used on the presentation page of 100 business websites from the toy sector (50 from Spain and 50 from the US). Following an observational and a quantitative analysis, the findings reveal remarkable statistical differences in the interactional discourse of this digital genre, which may be a valuable source of information for export companies to introduce their products abroad by means of their business websites. In addition, we believe that the business website can be used in the teaching and learning of Spanish and English for professional…
Conflicto, materialidad y enseñanza del inglés en Nazaret
2021
El capítulo narra la experiencia del proyecto "Words Matter/Palabras reales" en un colegio público del barrio desfavorecido de Nazaret, en la ciudad de Valencia, y lo contextualiza en la filosofía de los Nuevos materialismos, en los Nuevos estudios sobre literacidad, en el imperialismo lingüístico del inglés, y la teoría relacional del arte. HAR2017-85230-R The chapter describes the experience of the project "Words Matter / Palabras reales" as developed in a public school in the underprivileged neighborhood of Nazaret, in the city of Valencia (Spain). The description of the project is contextualized in New materialisms, New Literacy Studies, English linguistic imperialism, and the relationa…
Percepción del alumnado de Educación Secundaria sobre la mediación escolar en Castellón y Valencia
2016
La realidad social, en constante proceso de cambio, exige al sistema educativo un esfuerzo por actualizar las respuestas educativas frente a la mejora de la convivencia. Es en este contexto en el que la mediación ha dejado ver sus potencialidades educativas, ya que influye sobre la mejora del individuo, de las relaciones interpersonales y del clima escolar. No obstante, son escasas las investigaciones orientadas a conocer el impacto de la misma. En este artículo presentamos un estudio dirigido a conocer la valoración de la mediación atendiendo a las opiniones del alumnado de cinco centros educativos de secundaria de Valencia y cuatro de Castellón. Asimismo, se pretende detectar si existen d…
Enseñar, evaluar, aprender e investigar en el aula universitaria de la mano de la materia Lengua para Maestros
2014
Son muchas las cuestiones que podemos abordar al integrar la acción de las tecnologías en contextos de enseñanza presencial y el desarrollo del área lingüística: desde el comportamiento lingüístico ajustado a las interacciones oral y escrita, la creación de un clima propicio para despertar e incentivar el diálogo y la creatividad, la interpretación y valoración de textos, la capacitación para la investigación lingüística en la lengua como sistema y en sus relaciones interlingüísticas, etc. Sin embargo, el propósito de esta aportación es contribuir al desarrollo e investigación de la evaluación tomando como piedra angular la Evaluación Orientada al Aprendizaje (EOA) y el uso de plataformas v…