Search results for "ddc:"
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Management of Distribution Risks and Digital Transformation of Insurance Distribution—A Regulatory Gap in the IDD
2021
The Insurance Distribution Directive (IDD) aims to regulate insurance distribution in the EU regardless of distribution channels and means. Although new technologies affect insurance distribution, the IDD does not explicitly regulate this digital transformation. Insurers and intermediaries must comply with detailed business conduct rules that aim to counteract distribution risks. However, the IDD exempts ancillary insurance intermediaries from its scope when they meet certain conditions. The article highlights the regulatory framework on insurance, requiring insurers and intermediaries to address distribution risks, and analyses how this exemption affects the management of distribution risk…
Coworking spaces and makerspaces: Mapping the state of research
2022
Coworking and its merits and benefits have been under heavy scholarly investigation. Also in practice, the phenomenon with its characteristics and manifestations becomes increasingly relevant on many levels and for many different types of people and organizations. But why is that so, and how are the research activities distributed between researchers, countries, and journals? To answer these questions, we first analyzed existing literature and extracted the focal points of the respective approaches. We conducted a cluster analysis on the existing literature by analyzing data from the Web of Science. With these clusters, we show the development of the research stream and how the studies are …
Chemical composition of modern and fossil Hippopotamid teeth and implications for paleoenvironmental reconstructions and enamel formation – Part 1: M…
2012
Bioapatite in mammalian teeth is readily preserved in continental sediments and represents a very important archive for reconstructions of environment and climate evolution. This project provides a comprehensive data base of major, minor and trace element and isotope tracers for tooth apatite using a variety of microanalytical techniques. The aim is to identify specific sedimentary environments and to improve our understanding on the interaction between internal metabolic processes during tooth formation and external nutritional control and secondary alteration effects. Here, we use the electron microprobe to determine the major and minor element contents of fossil and modern molar enamel, …
Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic
2004
Erythropoietin (EPO) is both hematopoietic and tissue protective, putatively through interaction with different receptors. We generated receptor subtype–selective ligands allowing the separation of EPO's bioactivities at the cellular level and in animals. Carbamylated EPO (CEPO) or certain EPO mutants did not bind to the classical EPO receptor (EPOR) and did not show any hematopoietic activity in human cell signaling assays or upon chronic dosing in different animal species. Nevertheless, CEPO and various nonhematopoietic mutants were cytoprotective in vitro and conferred neuroprotection against stroke, spinal cord compression, diabetic neuropathy, and experimental autoimmune encephalomyeli…
Important role of Nfkb2 in the KrasG12D-driven carcinogenesis in the pancreas
2021
Abstract Background Oncogenic Kras initiates and drives carcinogenesis in the pancreas by complex signaling networks, including activation of the NFκB pathway. Although recent evidence has shown that oncogenic gains in Nfκb2 collaborate with Kras in the carcinogenesis, no data at the level of genetics for the contribution of Nfκb2 is available so far. Methods We used Nfkb2 knock-out mice to decipher the role of the gene in Kras-driven carcinogenesis in vivo. Results We show that the Nfkb2 gene is needed for cancer initiation and progression in KrasG12D-driven models and this requirement of Nfkb2 is mechanistically connected to proliferative pathways. In contrast, Nfκb2 is dispensable in agg…
Measurements and Observations in the XXI century (MOXXI) : innovation and multi-disciplinarity to sense the hydrological cycle
2018
ISI Document Delivery No.: FV7JXTimes Cited: 4Cited Reference Count: 249Tauro, Flavia Selker, John van de Giesen, Nick Abrate, Tommaso Uijlenhoet, Remko Porfiri, Maurizio Manfreda, Salvatore Caylor, Kelly Moramarco, Tommaso Benveniste, Jerome Ciraolo, Giuseppe Estes, Lyndon Domeneghetti, Alessio Perks, Matthew T. Corbari, Chiara Rabiei, Ehsan Ravazzani, Giovanni Bogena, Heye Harfouche, Antoine Brocca, Luca Maltese, Antonino Wickert, Andy Tarpanelli, Angelica Good, Stephen Alcala, Jose Manuel Lopez Petroselli, Andrea Cudennec, Christophe Blume, Theresa Hut, Rolf Grimaldi, SalvatoreTaylor & francis ltdAbingdon; To promote the advancement of novel observation techniques that may lead to new so…
From Silk to Digital Technologies: A Gateway to New Opportunities for Creative Industries, Traditional Crafts and Designers. The SILKNOW Case
2020
Nowadays, cultural heritage is more than ever linked to the present. It links us to our cultural past through the conscious act of preserving and bequeathing to future generations, turning society into its custodian. The appreciation of cultural heritage happens not only because of its communicative power, but also because of its economic power, through sustainable development and the promotion of creative industries. This paper presents SILKNOW, an EU-H2002 funded project and its application to cultural heritage, as well as to creative industries and design innovation. To this end, it presents the use of image recognition tools applied to cultural heritage, through the interoperability of …
Influence of the channel design on the heat and mass exchange of induction channel furnace
2011
PurposeThe purpose of this paper is to present in‐depth numerical modelling of heat and mass exchange in industrial induction channel furnace (ICF).Design/methodology/approachThe turbulent heat and mass exchange in the melt is calculated using a three‐dimensional (3D) electromagnetic model and a 3D transient large eddy simulation method. The simulation model has been verified by flow velocity and temperature measurements, which were carried out using an industrial sized channel inductor operating with Wood's metal as a low temperature model melt.FindingsThe ICF is well‐established for melting, holding and casting in the metallurgical industry. But there are still open questions regarding th…
Numerical studies of the melting process in the induction furnace with cold crucible
2008
PurposeAims to present recent activities in numerical modeling of cold crucible melting process.Design/methodology/approach3D numerical analysis was used for electromagnetic problem and 3D large eddy simulation (LES) method was applied for fluid flow modeling.FindingsThe comparative modeling shows, that higher H/D ratio of the melt is more efficient when total power consumption is considered, but this advantage is held back by higher heat losses through the crucible walls. Also, calculations reveal that lower frequencies, which are energetically less effective, provide better mixing of the melt.Originality/value3D electromagnetic model, which allows to take into account non‐symmetrical dist…
The measurement programme at the neutron time-of-flight facility n_TOF at CERN
2016
Neutron-induced reaction cross sections are important for a wide variety of research fields ranging from the study of nuclear level densities, nucleosynthesis to applications of nuclear technology like design, and criticality and safety assessment of existing and future nuclear reactors, radiation dosimetry, medical applications, nuclear waste transmutation, accelerator-driven systems and fuel cycle investigations. Simulations and calculations of nuclear technology applications largely rely on evaluated nuclear data libraries. The evaluations in these libraries are based both on experimental data and theoretical models. CERN’s neutron time-of-flight facility n TOF has produced a considerabl…