Search results for "designer"
showing 10 items of 39 documents
Energy planning methodology of net-zero energy solar neighborhoods in the Mediterranean basin
2016
The article proposes a simplified methodology to optimize solar energy gains at district level in the Mediterranean area toward the achievement of the net-zero energy district target, to be applicable as well in similar hot climates. The approach includes a wide use of parametric analysis to explore the most impactful aspects of the design of solar net-zero energy districts: single unit shape, building mutual distances, road shape, building orientation, photovoltaics area availability to identify the optimal design solution. Thirty-two different district configurations are explored: results show that in the Mediterranean context, it is possible to reach the net-zero energy district target i…
Interleukin-6 and Soluble Interleukin-6 Receptor: Direct Stimulation of gp130 and Hematopoiesis
1998
T HE INTERLEUKIN-6 (IL-6) family of cytokines acts via receptor complexes that contain at least one subunit of the signal transducing protein gp130.[1][1] The family comprises IL-6, IL-11, ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), leukemia inhibitory factor (LIF), and oncostatin M
“Krokodil”—Revival of an Old Drug with New Problems
2012
In order to summarize current knowledge about the drug "Krokodil" a systematic review including a literature search of the databases PubMed, Embase, Scopus, and Google was conducted in December 2011. According to information acquired, "Krokodil" is a mixture of several substances and was first reported to have been used in Russia in 2003. The core agent of "Krokodil" is desomorphine, an opioid-analogue that can be easily and cheaply manufactured by oneself. Self-production results in a contaminated suspension that is injected intravenously. Due to its pharmacologic features, desomorphine shows a high potential to cause dependence. Against the background of first possible cases of "Krokodil"…
Behavioural and pharmacological characterization of a novel cannabinomimetic adamantane-derived indole, APICA, and considerations on the possible mis…
2015
The novel adamantane derivative APICA (N-(adamantan-1-yl)-1-pentyl-1H-indole-3-carboxamide) was recently identified as a cannabinomimetic indole of abuse. Despite its novel structure, APICA recalls cannabinomimetic indoles, such as representative member JWH-018.In present study, the effects of APICA (1-3 mg/kg, i.p.) were tested in C57BL/6J mice, in the Tetrad task which includes the assessment of: body temperature; locomotor activity and behavioural reactivity; nociception; motor coordination; declarative memory. Furthermore, pre-treatment with the CB1 antagonist AM251 (3 mg/kg, i.p.) or the CB2 antagonist AM630 (3 mg/kg, i.p.) was carried out to characterize APICA activity.Our results sho…
Sensitive screening of synthetic cannabinoids using liquid chromatography quadrupole time-of-flight mass spectrometry after solid phase extraction.
2021
Analysis of synthetic cannabinoids still poses a challenge for many institutions due to the number of available substances and the constantly changing drug market. Both new and well-known substances keep appearing and disappearing on the market, making it hard to adapt analytical methods in a timely manner. In this study, we developed a qualitative screening approach for synthetic cannabinoids and their metabolites by means of liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF-MS). Samples were measured in data-dependent auto-MS/MS mode and identified by fragment spectra, retention time and accurate mass. Two established solid phase extractions were compared using fo…
Novel high-performance QCA Fredkin gate and designing scalable QCA binary to gray and vice versa
2022
AbstractIn the design of digital logic circuits, QCA technology is an excellent alternative to CMOS technology. Its advantages over CMOS include low power consumption, fast circuit switching, and nanoscale design. Circuits that convert data between different formats are code converters. Code converters have an essential role in high-performance computing and signal processing. In this paper, first, we proposed a novel QCA structure for the quantum reversible Fredkin gate. Second, we proposed 4-bit and 8-bit QCA binary-to-gray converter and vice versa. For the second proposal, both reversible and irreversible structures are suggested. The proposed structures are scalable up to N bits. To cha…
Presentazione. Distacco, poetica, eresia: tre parole chiave per introdurre le opere e il lavoro di Umberto Riva
2023
Questo volume raccoglie una vasta e articolata gamma di contributi che analizzano le opere e le esperienze progettuali di Umberto Riva, da prospettive diverse: le diverse prospettive non si differenziano fra loro soltanto per ciò che riguarda le competenze disciplinari degli Autori dei contributi, ma anche per il metodo di analisi critica impiegato, e per la forma narrativa che ne consegue. Quest’ultima, in particolare, risente anche delle differenze generazionali fra gli Autori: la dimensione della memoria e della narrazione retrospettiva di esperienze condivise prevale, come è naturale che sia, in coloro che con Umberto Riva hanno condiviso attività, riflessioni, sperimentazioni, come nel…
斯蒂法诺 阿斯利. Stefano Asili / Homo faber designer. Stefano Asili
2013
Stefano Asili 的职业道路曲折而不寻常，但 个中乐趣并未因此而减少。他没有像大多数 人一样，就读于艺术相关的专业，然后理所 当然地锁定最终的职业方向。他就读于和艺 术毫无关联的物理专业。但毕业后，他才明 白自己这一生想投身的事业，也就是 Albe Steiner 描述的，平面设计这门手艺。我在这 里用的词是“手艺”而非“职业”是有充分 理由的。相较于“职业”，“手艺”这一概 念从工艺的角度更强调人和物的密切关系， 这种关系是这两者间持续的对话，中间包含 思想、研究、实验以及改变的交流。这种关 系毋庸置疑已成为工艺实践的核心 Strano e tortuoso, ma non per questo meno interessante, è il percorso di Stefano Asili. Egli non ha come la maggior parte delle persone, compiuto degli studi che in maniera naturale lo hanno condotto alla definitiva configurazione professionale. Egli è arrivato da lontano, da una disciplina scientifica come la fisica, nella quale si è laureato, a comprendere che quanto voleva fare nella sua vita, era proprio il mestiere di g…
Design e poetica
2023
Conoscere nell’intimo la poetica che caratterizza l’opera di un Maestro dell’Architettura o del Design è una impresa culturale molto impegnativa, perché non sono unicamente gli apparati tecnici o la formazione tecnologica che la definiscono. Altro si aggiunge a tale assunti di base, come il sentimento, il rapporto con il materiale da plasmare, da trasformare, trasferendo le conoscenze acquisite, gli stati d’animo, gli umori, l’amore per il materiale che si arrende e si dona all’Artigiano-Designer. L’interesse ad indagare su Riva e sulla sua poetica stimola inevitabilmente l’autore di questo breve testo a sostenere come vi sia un legame molto stretto fra tecnologia e poetica.
Integrazione di celle fotovoltaiche ibride nel vetromattone
2012
L’invenzione riguarda l’integrazione del vetromattone con celle solari ibride (organiche/inorganiche), conosciute come Dye-sensitized Solar Cell (DSC). La combinazione del vetromattone con le DSC consente di migliorare le prestazioni del prodotto originario rendendolo in grado di produrre energia pulita. Le caratteristiche di trasparenza e isolamento termo-acustico del prodotto possono essere regolate agendo sulla configurazione delle DSC. Il prodotto può essere assemblato a formare pannelli fotovoltaici per la realizzazione di facciate traslucide energeticamente “attive” in varie condizioni luminose (condizioni di luce diffusa o artificiale) e indipendentemente dall’angolo di radiazione so…