Search results for "developmental"

Stick around: Cell–Cell Adhesion Molecules during Neocortical Development

2021

The neocortex is an exquisitely organized structure achieved through complex cellular processes from the generation of neural cells to their integration into cortical circuits after complex migration processes. During this long journey, neural cells need to establish and release adhesive interactions through cell surface receptors known as cell adhesion molecules (CAMs). Several types of CAMs have been described regulating different aspects of neurodevelopment. Whereas some of them mediate interactions with the extracellular matrix, others allow contact with additional cells. In this review, we will focus on the role of two important families of cell–cell adhesion molecules (C-CAMs), classi…

Structural analysis of network models in tetrapod skulls : evolutionary trends and structural constraints in morphological complexity, integration an…

2013

Background Ever since classic anatomists like George Cuvier, Geoffroy St. Hilaire, or Richard Owen laid down the fundamental principles of comparative anatomy in the 19th century, connections among anatomical parts have been essential for the recognition of biological homologies. However, few studies have addressed the possibility of implementing an adequate methodological tool to use connections among parts to unveil problems in morphology; although Woodger, Rashevsky, Riedl, and, more recently, Rasskin-Gutman pointed in this direction. In the last decades Network Theory has been developed as a novel conceptual and methodological framework to deal with the relational properties that emerge…

Reproducibility of Brain Responses: High for Speech Perception, Low for Reading Difficulties

2019

Neuroscience findings have recently received critique on the lack of replications. To examine the reproducibility of brain indices of speech sound discrimination and their role in dyslexia, a specific reading difficulty, brain event-related potentials using EEG were measured using the same cross-linguistic passive oddball paradigm in about 200 dyslexics and 200 typically reading 8–12-year-old children from four countries with different native languages. Brain responses indexing speech and non-speech sound discrimination were extremely reproducible, supporting the validity and reliability of cognitive neuroscience methods. Significant differences between typical and dyslexic readers were fou…

Global epidemiology of coronavirus disease 2019 and lessons for effective control of this and future pandemics

2021

Barely 1 year after severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) was first reported in China, the virus has infected approximately 120 million people, caused around 3 million deaths, and adversely affected the global economy Despite stringent measures to flatten the epidemiologic curve of the pandemic, there have been spikes and waves of the infection in many countries, particularly in the American, European, and Asian continents This review critically evaluated the global epidemiology of the novel coronavirus disease 2019 (COVID-19) to provide advice on other possible ways of managing the disease as various COVID-19 vaccines are being rolled out To effectively control this …

Event-related potentials as a measure of speech cue processing in newborns with genetic risk for dyslexia

1999

Meaning in Life Buffers the Association between Perceived Burdensomeness, Thwarted Belongingness, and Frequency of Non-Suicidal Self-Injuries in Span…

2021

Background: Adolescence is a developmental stage when there is a high risk of engaging in non-suicidal self-injury (NSSI). There is recent interest in the study of thwarted belongingness and perceived burdensome as variables associated with the frequency of NSSI in adolescents. Meaning in life (MIL) might be negatively associated with thwarted belongingness and perceived burdensomeness. To date, no studies have analyzed the buffering role of MIL in the association between thwarted belongingness and perceived burdensomeness and the frequency of lifetime NSSI in Spanish adolescents. Aims: (a) To test whether thwarted belongingness and perceived burdensomeness are associated with frequency of …

Betatrophin Levels Are Related to the Early Histological Findings in Nonalcoholic Fatty Liver Disease

2021

Betatrophin, a liver hormone, regulates glucose and lipid metabolism. We investigated the betatrophin levels in nonalcoholic fatty liver disease (NAFLD) and searched for any relationship with histological severity and metabolic parameters. Fifty males with NAFLD [Nonalcoholic Steatohepatitis (NASH) (n = 32)

Trans-Contextual Model Predicting Change in Out-of-School Physical Activity: A One-Year Longitudinal Study

2021

The aim of the current study was to test the long-term predictive validity of the trans-contextual model in accounting for variance in adolescents’ out-of-school physical activity measured by self-report and accelerometer based-devices over a one-year period. Secondary school students ( N  =  265) aged 11 to 15 years completed a three-wave survey on two occasions in time, spanning a one-year interval, measuring perceived autonomy support in physical education (PE), peer and parent autonomy support in leisure-time, autonomous and controlled motivation in PE and leisure-time, attitude, subjective norms, perceived behavioural control, intention, and out-of-school physical activity both by sel…

Coping strategies in life stories of young adults with foster care backgrounds

2021

Tutkimuksessa tarkasteltiin sijoitettuna olleiden nuorten aikuisten selviytymiskeinoja 18 yksilöhaastattelun avulla. Fenomenologisella analyysilla (IPA; Smith & Osborn, 2003. Interpretative phenomenological analysis. Teoksessa J. A. Smith (toim.), Qualitative Psychology (s. 51–80). Sage) tunnistettiin kolme pääteemaa liittyen selviytymiskeinoihin vastoinkäymisissä ja haasteissa: sisäänpäin suuntautuminen, ulospäin suuntautuminen sekä omiin elinolosuhteisiin vaikuttaminen. Lisäksi tunnistettiin keino, joka oli käytössä vain varhaisaikuisuudessa, hyväksyminen. Tulosten perusteella on tärkeää kuulla sijoitettuna olleita nuoria aikuisia koskien heidän selviytymiskeinojaan sekä lisätä sijaisperh…

A common biological basis of obesity and nicotine addiction

2013

Contains fulltext : 128630.pdf (Publisher’s version ) (Open Access) Smoking influences body weight such that smokers weigh less than non-smokers and smoking cessation often leads to weight increase. The relationship between body weight and smoking is partly explained by the effect of nicotine on appetite and metabolism. However, the brain reward system is involved in the control of the intake of both food and tobacco. We evaluated the effect of single-nucleotide polymorphisms (SNPs) affecting body mass index (BMI) on smoking behavior, and tested the 32 SNPs identified in a meta-analysis for association with two smoking phenotypes, smoking initiation (SI) and the number of cigarettes smoked …