Search results for "differentiation"
showing 10 items of 1605 documents
The Analysis of Consumer Behavior in Relationship to a Global Brand in the Lodging Industry, Across Europe and North America Abstract: The world is c…
2011
EVALUATING A CUSTOMER-CENTRIC APPROACH
2007
Customer focus is, at best, only one element of the relationship between a company and its customers. At worst it is a board-room buzzworld, witch makes every board member feel a little more secure. Not unlike the phrase “working towards equal opportunities”, it is showing an awareness of a need but is not addressing the issues. Customer focus must lead to something meaningful, will probably require sacrifices and is just one of the steps necessary to become truly customer-centric. A customer focus puts your customers high on your list of priorities. When you put your customers into the heart of your business, make customers part of the culture, then you to become customer-centric.
Effects of extra virgin olive oil phenols on HL60 cell lines sensitive and resistant to anthracyclines
2009
The aim of our study was to evaluate the capability of a crude extract of phenols from extra virgin olive oil of Moraiolo cultivar to induce apoptosis and/or differentiation in sensitive and resistant HL60 cell lines to anticancer drugs (Typical Multidrug Resistance). Our data highlight that the crude extract is able to induce apoptosis on both sensitive and resistant cells, whereas the exposure to a number of anticancer drugs does not induce apoptosis in resistant cells. In differentiation experiments we investigated the capability of crude extract of phenols to induce the expression of CD11 granulocytic or CD14 monocytic cell surface antigen in sensitive and resistant HL60 cell lines. At …
El espejo imperfecto: Píramo y Tisbe en los relatos medievales franceses
2019
La historia de Píramo y Tisbe narrada por Ovidio en Las metamorfosis ha dado lugar a un número importante de relatos sobre los dos amantes en la literatura medieval francesa. En este trabajo observamos la constelación francesa del relato ovidiano centrándonos en el tratamiento que ha tenido un elemento fundamental del universo de ficción ovidiana: su oscilación entre identificar y diferenciar a los dos amantes. Se observa en las versiones medievales francesas una marcada tendencia a individualizar al personaje femenino y darle más relieve, aunque no siempre ocurre así. Una tensión similar, de hecho, se observa en las interpretaciones morales y alegóricas. Cada autor ha extendido, pues, la c…
Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function
2020
In addition to their antibiotic activities, azithromycin (AZM) exhibits anti-inflammatory effects in various respiratory diseases. One of the potent anti-inflammatory mechanisms is through inhibition of CD4+ helper T (Th) cell effector function. However, their impact on specific Th subset is obscure. Herein, we demonstrate the cellular basis of phenotypic and functional alterations associated with Th subsets following AZM treatment in vitro. Using well-characterized Th subset specific chemokine receptors, we report significant suppression of T cell receptor (TCR)-stimulated hyperactivated CCR4+CXCR3+ (Th0) expansion compared to CCR4-CXCR3+ (Th1-like) and CCR4+CXCR3- (Th2-like) cells. Intere…
IFI16 expression is related to selected transcription factors during B-cell differentiation
2015
The interferon-inducible DNA sensor IFI16 is involved in the modulation of cellular survival, proliferation, and differentiation. In the hematopoietic system, IFI16 is consistently expressed in the CD34+ stem cells and in peripheral blood lymphocytes; however, little is known regarding its regulation during maturation of B- and T-cells. We explored the role of IFI16 in normal B-cell subsets by analysing its expression and relationship with the major transcription factors involved in germinal center (GC) development and plasma-cell (PC) maturation.IFI16mRNA was differentially expressed in B-cell subsets with significant decrease inIFI16mRNA in GC and PCs with respect to naïve and memory subs…
IL-12 Expands and Differentiates Human Vγ2Vδ2 T Effector Cells Producing Antimicrobial Cytokines and Inhibiting Intracellular Mycobacterial Growth
2019
While IL-12 plays a key role in differentiation of protective CD4+ Th1 response, little is known about mechanisms whereby IL-12 differentiates other T-cell populations. Published studies suggest that predominant Vγ2Vδ2 T cells in humans/nonhuman primates (NHP) are a fast-acting T-cell subset, with capacities to rapidly expand and produce Th1 and cytotoxic cytokines in response to phosphoantigen (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP) produced by Mycobacterium tuberculosis (Mtb) or others. However, whether IL-12 signaling pathway mediates fast-acting and Th1 or anti-microbial features of Vγ2Vδ2 T cells remains poorly defined. Here, we show that IL-12, but not other IL-12 fami…
B lymphocyte intestinal homing in inflammatory bowel disease.
2011
Abstract Background Inflammatory bowel disease (IBD) is thought to be due to an abnormal interaction between the host immune system and commensal microflora. Within the intestinal immune system, B cells produce physiologically natural antibodies but pathologically atypical anti-neutrophil antibodies (xANCAs) are frequently observed in patients with IBD. The objective is to investigate the localisation of immunoglobulin-producing cells (IPCs) in samples of inflamed intestinal tissue taken from patients with IBD, and their possible relationship with clinical features. Methods The IPCs in small intestinal, colonic and rectal biopsy specimens of patients with IBD were analysed by means of immun…
Coercion and Non-State Law
2016
Abstract The aim of this paper is to introduce some elements of a research project in legal philosophy. Its goal is to identify some crucial topics for the definition of law. In the first part (§§ 1 & 2) I analyse some methodological difficulties of the dominant research on the definition of law. In the second part (§§ 3 & 4) I refer to some current development of law and sketch some characteristics of the object to be defined, corresponding to what can be called the process of law differentiation. In the last part of this contribute I try to sum up some elements to be taken in account in the definition of a differentiated law. Key words: Differentiation of law, Legal pluralism, Jus…
Individuālās pieejas nodrošināšana bērniem ar mācīšanās traucējumiem vispārējās izglītības iestādē 3. un 4. klasē
2017
Diplomdarba „Individuālās pieejas nodrošināšana bērniem ar mācīšanās traucējumiem vispārējās izglītības iestādē 3.un 4. klasē” mērķis ir izpētīt un analizēt individuālās pieejas veidus bērniem ar mācīšanās traucējumiem vispārējās izglītības iestādē. Pētījuma aktualitāte izriet no galvenajiem principiem kvalitātes veicināšanai iekļaujošā izglītībā (Eiropas speciālās izglītības aģentūra, 2009). Galveno principu izstrādāšanas svarīgākais mērķis ir veicināt līdzdalību iekļaujošā izglītībā, nodrošinot kvalitatīvus izglītības pakalpojumus. Iekļaujošās izglītības mērķis ir paplašināt pieejamību izglītībai un veicināt visu izglītojamo līdzdalību un iespējas, lai īstenotu savu potenciālu. Pozitīvas …