Search results for "folds"
showing 10 items of 298 documents
Impact of coronary calcification on outcomes after ABSORB scaffold implantation: insights from the GABI-R registry.
2020
OBJECTIVE To investigate the outcomes after bioresorbable scaffold (BRS) implantation in calcified coronary lesions. In calcified coronary lesions, durable metallic drug-eluting stent (DES) implantation is associated with worse clinical outcomes compared to noncalcified lesions. Although not recommended, BRSs were frequently implanted in calcified lesions in clinical practice. Their outcome is not well investigated. METHODS Between November 2013 and January 2016, 3326 patients were enrolled in the German-Austrian ABSORB ReglstRy (GABI-R). Lesion calcification severity was classified into no (n = 1144), mild (n = 1306), and moderate-to-severe (n = 690) calcification. RESULTS Patients with ca…
Preparation, characterization and in vitro test of composites poly-lactic acid/hydroxyapatite scaffolds for bone tissue engineering.
2018
Abstract In this work, the possibility to produce composite Poly-L-lactic acid (PLLA)/Hydroxyapatite (HA) porous scaffolds via Thermally Induced Phase Separation (TIPS) for bone tissue engineering applications was investigated. Several PLLA/HA wt/wt ratios (95/5, 90/10, 70/30, 50/50, 34/66) were tested and the as-obtained scaffolds were characterized via Scanning Electron Microscopy, Wide Angle X-Ray Diffraction, Thermogravimetric analysis, Gas Pycnometry, Differential Scanning Calorimetry and mechanical compression test. Morphological analysis revealed an open structure with interconnected pores and HA particles embedded in the polymer matrix. Finally, cell cultures were carried out into t…
In vitro degradation of porous PLLA/pearl powder composite scaffolds
2013
Abstract The in vitro degradation behavior of poly- l -lactide (PLLA), PLLA/aragonite pearl powder and PLLA/vaterite pearl powder scaffolds was investigated. The scaffolds were soaked in phosphate buffer solution (PBS) up to 200 days. Scanning electron microscopy (SEM), gel permeation chromatography (GPC), and differential scanning calorimetry (DSC) were used to observe any degradation of the scaffolds. Degradation behaviors such as changes in pH, porosity, bulk density, water absorption, weight loss and mechanical properties were discussed. The results show that a gradual increase of the pH in composite scaffolds can decrease the rate of hydrolysis of PLLA. PLLA/vaterite and PLLA/aragonite…
In vivo comparison of a granular and putty form of a sintered and a non-sintered silica-enhanced hydroxyapatite bone substitute material
2019
Improved handling characteristics of bone substitute materials may facilitate surgical handling. However, the respective modifications should not alter the biological activity. For comparison of a ...
Recombinant mussel protein Pvfp5β enhances cell adhesion of poly(vinyl alcohol)/k-carrageenan hydrogel scaffolds
2022
Polymeric hydrogels are increasingly considered as scaffolds for tissue engineering due to their extraordinary resemblance with the extracellular matrix (ECM) of many tissues. As cell adhesion is a key factor in regulating important cell functions, hydrogel scaffolds are often functionalized or loaded with a variety of bioactive molecules that can promote adhesion. Interesting biomimetic approaches exploit the properties of mussel-inspired recombinant adhesive proteins. In this work, we prepared hydrogel scaffolds with a 50%w mixture of k-carrageenan (kC) and polyvinyl alcohol (PVA), by a two-step physical gelation process, and we coated them with Perna viridis foot protein-5 beta (Pvfp5 be…
Efficient Design of Waveguide Manifold Multiplexers Based on Low-Order EM Distributed Models
2015
In this paper, a new systematic technique to design manifold-coupled multiplexers in waveguide technology is proposed. The new technique uses generalized low-order electromagnetic (EM) distributed models, which constitute a half-way point between the fast, but imprecise, analytical models, and the more accurate, but costly, full-wave EM models. The method can be applied to contiguous and noncontiguous channel multiplexers, in both E-plane or H-plane configurations. This paper covers the complete design procedure for manifold multiplexers, starting from the required specifications and finishing with the physical dimensions. After explaining the general design technique for multiplexers with …
Analysis of the Biological Response of Endothelial and Fibroblast Cells Cultured on Synthetic Scaffolds with Various Hydrophilic/Hydrophobic Ratios: …
2009
In this study we developed polymer scaffolds intended as anchorage rings for cornea prostheses among other applications, and examined their cell compatibility. In particular, a series of interconnected porous polymer scaffolds with pore sizes from 80 to 110 microns were manufactured varying the ratio of hydrophobic to hydrophilic monomeric units along the polymer chains. Further, the effects of fibronectin precoating, a physiological adhesion molecule, were tested. The interactions between the normal human fibroblast cell line MRC-5 and primary human umbilical vein endothelial cells (HUVECs) with the scaffold surfaces were evaluated. Adhesion and growth of the cells was examined by confocal…
Spectral rigidity and invariant distributions on Anosov surfaces
2014
This article considers inverse problems on closed Riemannian surfaces whose geodesic flow is Anosov. We prove spectral rigidity for any Anosov surface and injectivity of the geodesic ray transform on solenoidal 2-tensors. We also establish surjectivity results for the adjoint of the geodesic ray transform on solenoidal tensors. The surjectivity results are of independent interest and imply the existence of many geometric invariant distributions on the unit sphere bundle. In particular, we show that on any Anosov surface $(M,g)$, given a smooth function $f$ on $M$ there is a distribution in the Sobolev space $H^{-1}(SM)$ that is invariant under the geodesic flow and whose projection to $M$ i…
THE 1-HARMONIC FLOW WITH VALUES IN A HYPEROCTANT OF THE N-SPHERE
2014
We prove the existence of solutions to the 1-harmonic flow — that is, the formal gradient flow of the total variation of a vector field with respect to the [math] -distance — from a domain of [math] into a hyperoctant of the [math] -dimensional unit sphere, [math] , under homogeneous Neumann boundary conditions. In particular, we characterize the lower-order term appearing in the Euler–Lagrange formulation in terms of the “geodesic representative” of a BV-director field on its jump set. Such characterization relies on a lower semicontinuity argument which leads to a nontrivial and nonconvex minimization problem: to find a shortest path between two points on [math] with respect to a metric w…
In Vivo Modulation of Angiogenesis and Immune Response on a Collagen Matrix via Extracorporeal Shockwaves
2020
The effective management of tissue integration and immunological responses to transplants decisively co-determines the success of soft and hard tissue reconstruction. The aim of this in vivo study was to evaluate the eligibility of extracorporeal shock wave therapy (ESWT) with respect to its ability to modulate angiogenesis and immune response to a collagen matrix (CM) for tissue engineering in the chorioallantoic membrane (CAM) assay, which is performed with fertilized chicken eggs. CM were placed on the CAM on embryonic development day (EDD) 7