Search results for "fusion"
showing 10 items of 4513 documents
Molecular semiconductor-doped insulator (MSDI) heterojunctions as new transducers for chemical sensors
2011
International audience; This article describes a new principle of transduction involving an heterojunction between a Molecular Semiconductor and a Doped Insulator (MSDI). Herein, we report on an MSDI-based sensor featuring an heterojunction between a lutetium bisphthalocyanine (LuPc), which acts as Molecular Semiconductor (MS) and a thin film of Doped Insulator (DI) made of substituted or fluorinated copper phthalocyanine (CuFPc, where = 0, 8, 16). Previously, we reported the peculiar effect of the heterojunction on the MSDI's electronic behavior, suggesting this device as a new kind of transducer for gas chemosensing. Indeed, of particular significance was the key role of modulator played …
Dynamiques de populations en milieu hétérogène : modèles et estimation de paramètres
2017
Prod 2017-344i SPE équipe EA GESTAD INRA; National audience; Cet exposé traite de (i) la modélisation de dynamiques de populations dans des paysages hétérogènes, (ii) la modélisation des paysages eux-mêmes, (iii) l'estimation des paramètres de ces modèles à partir de données d'abondance ou de données génétiques. Nous nous concentrerons sur deux grandes classes de modèles de dynamique des populations : les modèles individu-centrés basés sur des équations différentielles stochastiques, et les modèles de réaction-diffusion. Après une introduction du lien entre ces approches, 5 illustrations issues des projets sont présentées: - modélisation de paysages hétérogènes fragmentés, via l’outil MULTI…
How does shear zone nucleate? An example from the Suretta nappe (Swiss Eastern Alps)
2016
In order to address the question of the processes involved during shear zone nucleation, we present a petro-structural analysis of millimetre-scale shear zones within the Roffna rhyolite (Suretta nappe, Eastern central Alps). Field and microscopic evidences show that ductile deformation is localized along discrete fractures that represent the initial stage of shear zone nucleation. During incipient brittle deformation, a syn-kinematic metamorphic assemblage of white mica + biotite + epidote + quartz precipitated at ca. 8.5 ± 1 kbar and 480 ± 50 °C that represent the metamorphic peak conditions of the nappe stacking in the continental accretionary wedge during Tertiary Alpine subduction. The…
Structure-function analysis of peroxisomal ATP-binding cassette transporters using chimeric dimers
2014
Background: Peroxisomal ABC transporters are predicted to function as homodimers in mammals. [br/] Results: ABCD1 interacts with ABCD2. Chimeric proteins mimicking full-length dimers represent novel tools for functional study. Artificial homodimers and heterodimers are functional. [br/] Conclusion: Interchangeability between ABCD1 and ABCD2 is confirmed, but PUFA transport depends on ABCD2. [br/] Significance: For the first time, heterodimers in mammals are proven to be functional.[br/] ABCD1 and ABCD2 are two closely related ATP-binding cassette half-transporters predicted to homodimerize and form peroxisomal importers for fatty acyl-CoAs. Available evidence has shown that ABCD1 and ABCD2 …
The role of enzymes in biomineralization processes.
2008
56 pages; International audience
Brain lateralization probed by water diffusion at the atomic to micrometric scale
2019
International audience; Combined neutron scattering and diffusion nuclear magnetic resonance experiments have been used to reveal significant interregional asymmetries (lateralization) in bovine brain hemispheres in terms of myelin arrangement and water dynamics at micron to atomic scales. Thicker myelin sheaths were found in the left hemisphere using neutron diffraction. 4.7 T dMRI and quasi-elastic neutron experiments highlighted significant differences in the properties of water dynamics in the two hemispheres. The results were interpreted in terms of hemisphere-dependent cellular composition (number of neurons, cell distribution, etc.) as well as specificity of neurological functions (s…
In vivo and in vitro sensitivity of blastic plasmacytoid dendritic cell neoplasm to SL-401, an interleukin-3 receptor targeted biologic agent.
2015
International audience; Blastic plasmacytoid dendritic cell neoplasm is an aggressive malignancy derived from plasmacytoid dendritic cells. There is currently no accepted standard of care for treating this neoplasm, and therapeutic strategies have never been prospectively evaluated. Since blastic plasmacytoid dendritic cell neoplasm cells express high levels of interleukin-3 receptor α chain (IL3-Rα or CD123), antitumor effects of the interleukin-3 receptor-targeted drug SL-401 against blastic plasmacytoid dendritic cell neoplasm were evaluated in vitro and in vivo. The cytotoxicity of SL-401 was assessed in patient-derived blastic plasmacytoid dendritic cell neoplasm cell lines (CAL-1 and …
Dynamiques spatio-temporelles de la vigne (Vitis vinifera) au cours de l’Holocène en France d’après les enregistrements archéobotaniques (graines et …
2021
International audience; Le vin joue un rôle économique et culturel capital depuis l’âge du Fer en France. Dès cette époque, la viticulture s’implante dans le Midi méditerranéen puis va progressivement se diffuser dans la zone tempérée. L’archéologie a bien montré à quel point le Haut-Empire romain représente une étape clé dans cette diffusion (Poux et al. 2011). Cependant, les différents marqueurs à disposition de l’archéologie culturelle et spatiale (aménagements, structures, mobiliers) sont généralement limités à des fenêtres chrono-géographiques particulières. Changeant en fonction du contexte technique, culturel et environnemental, aucun ne permet véritablement de suivre l’expansion de …
The "very loyal pinot": historical trajectory of a mythic grape variety of Burgundy
2019
Grape varieties began to appear in historical sources at the end of Middle Ages. In Burgundy, early mentions of pinot correspond to an evolution in the way wines were named. From the 14th century onwards, pinot wines have persistently demonstrated to express elements of superior quality. This variety is often offered at expensive prices due to the nature of its rarity, and as a result is commonly reserved explicity for the élites. However, it is suggested that the roles of The Dukes of Burgundy, concerning the promotion of grape varieties, is to be moderated. Therefore, if Philippe le Hardi’s proclamation condemns « the very bad and very disloyal plant called gaamez » then, it is evident th…
Diffusion régionale du silex crétacé des minières de Saint-Gond (Marne, France) au Néolithique récent et final
2018
International audience; La région des Marais de Saint-Gond (Marne) comporte un très grand nombre de sites néolithiques. Elle est surtout connue pour ses nombreuses sépultures collectives en hypogées et en allées couvertes. Des ateliers de taille et des habitats y ont également été détectés. Tous ces sites ont fourni des quantités de silex taillés. L’origine de ces silex et le contexte géologique de la région n’avaient pas encore fait l’objet d’une étude détaillée. Depuis 2012 les prospections ont permis de localiser 17 minières et plusieurs dizaines d’affleurements de bancs de silex. Ces données montrent que le silex est très abondant dans la région et qu’il a été intensément exploité au Né…