Search results for "gate"
showing 10 items of 1811 documents
Highly enantioselective copper(I)-catalyzed conjugate addition of terminal alkynes to 1,1-difluoro-1-(phenylsulfonyl)-3-en-2-ones: new ester/amide su…
2013
A highly enantioselective copper-catalyzed conjugate alkynylation of monoactivated enones, namely 1,1-difluoro-1-(phenylsulfonyl)-3-en-2-ones, is described. The reaction products are obtained with good yields and excellent enantioselectivities (from 92 to 99% ee). The β-alkynylated difluoro(phenylsulfonyl) ketones can be converted into the corresponding β-alkynylated difluoro- and trifluoromethyl ketones, esters and amides. This is the first example on the use of 1,1-difluoro-1-(phenylsulfonyl)-3-en-2-ones as substrates in an enantioselective reaction, which have been shown to be new ester/amide surrogates.
Application of tris-allyl-DOTA in the preparation of DOTA–peptide conjugates
2006
Abstract The synthesis of tris-allyl-DOTA starting from cyclen and its application in the preparation of DOTA–peptide conjugates is reported. Clinically important conjugates such as DOTA–Tyr3-octreotide (DOTA–TOC), DOTA–Tyr3-octreotate (DOTA–TATE) as well as a DOTA–RGD peptide were synthesized in high yields with Fmoc solid phase peptide synthesis. The final, extremely reliable de-allylation was achieved on solid phase by different methods identifying morpholine/Pd(0) as the most suitable one obtaining all DOTA peptide conjugates in high yields. All DOTA–peptides were purified by reversed phase HPLC and structural identity was proved using MALDI-TOF mass spectrometry.
Theoretical study of the interaction between sodium ion and a cyclopeptidic tubular structure.
2007
DFT calculations have been carried out to describe the pathway of a sodium ion along the stacking direction of a tubular structure set up by five cyclopeptidic units, which can be considered a suitable model of a hollow tubular structure of indefinite length. A lattice of points inside the tubular structure is defined and the DFT interaction energy values with a sodium ion are obtained. The data allow predicting a zigzag path of the ion inside the hosting structure. © 2007 Wiley Periodicals, Inc. J Comput Chem, 2007
A Short Synthesis of Polysubstituted Pyrrolidines via α-(Alkylideneamino)nitriles
2004
α-(Alkylideneamino)nitriles can be deprotonated under mild conditions. Their conjugated anions react with enones in a 1,4-addition to yield δ-keto-α-(alkylideneamino)nitriles which in turn can be reduced to form pyrrolidines in a one-pot reaction sequence.
The fifteenth-century Catalan translation of the French "Danse macabre": A critical edition and English translation, from manuscript Miscel·lània 26,…
2015
The present article focuses on ff. cxlr-cviiir of the manuscript Miscel?lània 26, Arxiu de la Corona d’Aragó, Barcelona, which contain the only extant version of the fifteenth-century Catalan translation of the French Danse macabre. The article contains a philological study of this section of the manuscript, with particular attention to the relationship between the Catalan version of the Danse macabre and its French sources: this study serves as an introduction to a new critical edition of the Catalan translation proposed in the second part of the article. The critical text consists of a parallel edition of the Catalan version and manuscript lat. 14904, Bibliothèque nationale de France, Par…
Spectral rigidity and invariant distributions on Anosov surfaces
2014
This article considers inverse problems on closed Riemannian surfaces whose geodesic flow is Anosov. We prove spectral rigidity for any Anosov surface and injectivity of the geodesic ray transform on solenoidal 2-tensors. We also establish surjectivity results for the adjoint of the geodesic ray transform on solenoidal tensors. The surjectivity results are of independent interest and imply the existence of many geometric invariant distributions on the unit sphere bundle. In particular, we show that on any Anosov surface $(M,g)$, given a smooth function $f$ on $M$ there is a distribution in the Sobolev space $H^{-1}(SM)$ that is invariant under the geodesic flow and whose projection to $M$ i…
Improving the Frying Performance and Oxidative Stability of Refined Soybean Oil by Tocotrienol-Rich Unsaponifiable Matters of Kolkhoung (Pistacia khi…
2018
Increasing consumer awareness for all natural products has quickly led to growing research on new resources of potent and profitable natural antioxidants. In this context, for the first time, the Kolkhoung hull oil (KHO) (Pistacia khinjuk)-unsaponifiable matters (USM) (UHO) (100, 200, and 400 mg kg−1) were incorporated into refined soybean oil (RSO) and the oxidative stability of prepared oils was measured during 32 hours of frying. Then, the obtained results (oxidative stability) were compared to the samples containing tert-butyl hydroquinone (TBHQ) (100 mg kg−1) as a common synthetic antioxidant. According to the results of oxidative stability assays of acid values, conjugated diene value…
Report WS6: Immigration and new inhabitants in the Gateway Cities
2012
It is in the last years that the planning discipline has fully recognized immigration issues as decisive for their role both in the urban studies and in the policy design. Nowadays, in Italy and Europe, the shifting social composition of the cities asks the planner for new cognitive instruments and new strategies for the interventions on urban systems. The present report resumes the results of the workshop “Immigration and new inhabitants in the gateway cities” which took place inside the IX Biennial of Towns and Town Planners of Europe, held in Genoa in September 2011. In the two days of debate, a number of Italian and European examples has been presented: the report underlines three issue…
Thermal Induction of 9t12t Linoleic Acid: a New Pathway for the Formation of Conjugated Linoleic Acids
2009
Accepted version of an article published in the journal: International Journal of Engineering and Technology Published version available at: http://www.ijetch.org/papers/066.pdf Thermal induction of 9t12t fatty acid leading to the formation of Conjugated Linoleic Acids (CLA) has been demonstrated by subjecting glyceride, and methyl ester of the acid to heat treatment. Fifteen micro liter portions of the glyceride sample containing 9t12t fatty acid (trilinoelaidin) were placed in micro glass ampoules and sealed under nitrogen and then subjected to thermal treatment at 250oC. The glass ampoules were taken out at regular time intervals, and the contents were subjected to composition analysis b…
Generalized Bayesian pursuit: A novel scheme for multi-armed Bernoulli bandit problems
2011
Published version of a chapter in the book: IFIP Advances in Information and Communication Technology. Also available from the publisher at: http;//dx.doi.org/10.1007/978-3-642-23960-1_16 In the last decades, a myriad of approaches to the multi-armed bandit problem have appeared in several different fields. The current top performing algorithms from the field of Learning Automata reside in the Pursuit family, while UCB-Tuned and the ε -greedy class of algorithms can be seen as state-of-the-art regret minimizing algorithms. Recently, however, the Bayesian Learning Automaton (BLA) outperformed all of these, and other schemes, in a wide range of experiments. Although seemingly incompatible, in…