Search results for "gerontology"

showing 10 items of 2492 documents

Efectos de un programa de eliminación de sujeciones físicas sobre personas mayores con demencia en residencias

2016

Resumen Objetivo Analizar los resultados de eliminar las sujeciones fisicas en mayores con demencia que viven en residencias. Este objetivo se enmarca en un proceso mas amplio de modificacion del modelo de atencion residencial. Metodo Estudio cuasi experimental en dos residencias desde mayo de 2010 hasta mayo de 2012. Se recoge informacion en 7 momentos temporales y se efectua un analisis longitudinal. Tras formar al personal se retiraron progresivamente las sujeciones fisicas en el centro El Puig, mientras que en el centro Conarda se mantuvieron las sujeciones. Las variables principales medidas fueron: caidas, psicofarmacos administrados, asi como diversos indicadores de estado mental y fu…

03 medical and health sciencesAging0302 clinical medicinePersones grans dependentsMedicine (miscellaneous)030212 general & internal medicine030204 cardiovascular system & hematologyGeriatrics and GerontologyPersones grans
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Plädoyer für einen (berufs-) alltagstauglichen Begriff von Spiritualität

2021

Zusammenfassung Ein Blick auf die deutschsprachige Diskussion um Spiritual Care zeigt: Die Konzepte sind noch rar, die Grundlagen und Methoden spiritueller Kommunikation im Berufsalltag darstellen und entfalten. Dabei betonen so gut wie alle Stellungnahmen der Gesundheitsfachberufe die Wichtigkeit der Spiritualität in ihrer Arbeit. Der folgende Beitrag lenkt den Blick von der Metaebene der Diskussion um Spiritualität auf die Mikroebene der konkreten Situationen, die die Angehörigen der versorgenden Berufe in Krankenhaus, Altenheim und Palliative Care antreffen. In diesem Beitrag wird ein Begriff von Spiritualität vorgestellt, der nicht nur der Hochform dieser Dimension, sondern auch der im …

03 medical and health sciencesPlea030502 gerontology05 social sciencesSpirituality050109 social psychology0501 psychology and cognitive sciencesForestryPlant ScienceTheology0305 other medical sciencePsychologySpiritual Care
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International retirement migration revisited: From amenity seeking to precarity migration?

2018

International retirement migration has become a multifaceted field of research since the end of the twentieth century. The term refers to mobilities in old age to other countries, upon reaching ret...

03 medical and health sciencesPrecarityMobilities030502 gerontologyAmenityPolitical scienceField (Bourdieu)05 social sciences0507 social and economic geographyDemographic economics0305 other medical science050703 geographyTerm (time)Transnational Social Review
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Identificación de polimorfismos de nucleótido simple en centenarios

2016

Resumen Introduccion La longevidad viene determinada por la genetica propia de cada especie y por factores externos, tales como nutricionales, ambientales, sociales, etc. Sin embargo, los individuos mas longevos se caracterizan por presentar una mayor adaptacion al entorno condicionada predominantemente por su propia genetica. Dentro de una misma poblacion con relativa homogeneidad genotipica, podemos encontrar cambios sutiles en la secuencia de ADN que afectan unicamente a un nucleotido. Estos cambios denominados polimorfismos de nucleotido simple ( Single Nucleotide Polimorphisim [SNP]) se encuentran con una prevalencia mayor al 1-5% de la poblacion. Por ello, nos planteamos estudiar en i…

0301 basic medicine03 medical and health sciencesAging030104 developmental biologyMedicine (miscellaneous)Geriatrics and GerontologyRevista Española de Geriatría y Gerontología
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Identificación de polimorfismos de un solo nucleótido relacionados con la fragilidad

2018

Resumen Introduccion La busqueda de biomarcadores que permitan la deteccion y el posible tratamiento precoz de la fragilidad se ha convertido en uno de los objetivos primordiales de la comunidad cientifica geriatrica. El objetivo del presente estudio fue identificar polimorfismos de un solo nucleotido ([SNP] del ingles single nucleotide polymorphisms) relacionados con la fragilidad. Material y metodos El estudio se llevo a cabo en 152 sujetos de la cohorte del Estudio de Toledo (de 65 a 95 anos de edad), clasificados como fragiles (n = 78), y no fragiles (n = 74), segun los criterios de Fried. Tras la extraccion de sangre se aislo y amplifico el ADN para el analisis de SNP mediante la tecno…

0301 basic medicine03 medical and health sciencesAging030104 developmental biologyMedicine (miscellaneous)Geriatrics and GerontologyRevista Española de Geriatría y Gerontología
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Dénutrition protéino-énergétique extrême : un concept mal connu en EHPAD

2017

Resume Il existe une forme particuliere de denutrition proteino-energetique (DPE) en geriatrie : la denutrition proteino-energetique extreme (DPEE). Certaines personnes entrent en etablissement d’hebergement pour personnes âgees dependantes (EHPAD) en situation de DPEE, c’est-a-dire avec un indice de masse corporelle (IMC) inferieur a 18,5 kg/m 2 . Par sa similitude avec le syndrome de renutrition inapproprie (SRI) ou refeeding syndrome , la DPEE n’est pas toujours identifiee comme une situation a risque. Or, une approche nutritionnelle ordinaire peut avoir des consequences deleteres. Nous presentons une mise au point bibliographique sur les risques de renutrition inadapte de la DPEE de la …

0301 basic medicine03 medical and health sciencesPsychiatry and Mental health030109 nutrition & dietetics0302 clinical medicine030212 general & internal medicineNeurology (clinical)Geriatrics and GerontologyNPG Neurologie - Psychiatrie - Gériatrie
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Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis.

2021

We aimed to quantitatively characterize progressive brain network disruption in Amyotrophic Lateral Sclerosis (ALS) during cognition using the mismatch negativity (MMN), an electrophysiological index of attention switching. We measured the MMN using 128-channel EEG longitudinally (2-5 timepoints) in 60 ALS patients and cross-sectionally in 62 healthy controls. Using dipole fitting and linearly constrained minimum variance beamforming we investigated cortical source activity changes over time. In ALS, the inferior frontal gyri (IFG) show significantly lower baseline activity compared to controls. The right IFG and both superior temporal gyri (STG) become progressively hyperactive longitudina…

0301 basic medicineAdultMaleAgingmedicine.medical_specialtyMismatch negativityPrefrontal CortexElectroencephalographyAudiologybehavioral disciplines and activities03 medical and health sciences0302 clinical medicineCognitionmedicineHumansAttentionCognitive DysfunctionAmyotrophic lateral sclerosisAgedAged 80 and overHyperactivationmedicine.diagnostic_testbusiness.industryGeneral NeuroscienceAmyotrophic Lateral SclerosisMotor CortexCognitionElectroencephalographyMiddle Agedmedicine.diseasePrognosisTemporal LobeElectrophysiology030104 developmental biologymedicine.anatomical_structureCross-Sectional StudiesDisinhibitionFemaleNeurology (clinical)Geriatrics and Gerontologymedicine.symptombusiness030217 neurology & neurosurgeryDevelopmental BiologyMotor cortexNeurobiology of aging
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Centenarians Overexpress Pluripotency-Related Genes.

2018

Abstract Human mesenchymal cells can become pluripotent by the addition of Yamanaka factors OCT3/4, SOX2, c-MYC, KLF4. We have recently reported that centenarians overexpress BCL-xL, which has been shown to improve pluripotency; thus, we aimed to determine the expression of pluripotency-related genes in centenarians. We recruited 22 young, 32 octogenarian, and 47 centenarian individuals and determined the mRNA expression of Yamanaka factors and other stemness-related cell surface marker genes (VIM, BMP4, NCAM, BMPR2) in peripheral blood mononuclear cells by reverse transcription polymerase chain reaction. We found that centenarians overexpress OCT3/4, SOX2, c-MYC, VIM, BMP4, NCAM, and BMPR2…

0301 basic medicineAdultMalePluripotent Stem CellsAgingCellPeripheral blood mononuclear cellCohort Studies03 medical and health sciencesKruppel-Like Factor 40302 clinical medicineSOX2MedicineHumansGeneCells CulturedAged 80 and overbusiness.industryMesenchymal stem cellAge FactorsMembrane ProteinsReverse transcription polymerase chain reaction030104 developmental biologymedicine.anatomical_structureGene Expression RegulationKLF4Cancer researchLeukocytes MononuclearFemaleGeriatrics and GerontologyCentenarianbusiness030217 neurology & neurosurgeryThe journals of gerontology. Series A, Biological sciences and medical sciences
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New insights in the neurological phenotype of aceruloplasminemia in Caucasian patients

2017

Abstract Introduction The diagnosis aceruloplasminemia is usually made in patients with advanced neurological manifestations of the disease. In these patients prognosis is poor, disabilities are severe and patients often die young. The aim of our study was to facilitate recognition of aceruloplasminemia at a disease stage at which treatment can positively influence outcome. Currently, the neurological phenotype of aceruloplasminemia has been mainly described in Japanese patients. This ‘classical’ phenotype consists of cerebellar ataxia, hyperkinetic movement disorders and cognitive decline. In this study we describe the spectrum of neurological disease in Caucasian patients. Methods Data on…

0301 basic medicineAdultMalemedicine.medical_specialtyPediatricsAtaxiaMovement disordersBiologyWhite People03 medical and health sciencesNeurological manifestation0302 clinical medicinePhenotypic variabilitymedicineAceruloplasminemiaHumansCognitive declineAceruloplasminemiaPsychiatryDystoniaCerebellar ataxiaParkinsonismCeruloplasminChoreaNeurodegenerative DiseasesMiddle Agedmedicine.diseaseIron Metabolism DisordersPedigree030104 developmental biologyPsychiatric changesPhenotypeNeurologyFemaleNeurology (clinical)Geriatrics and Gerontologymedicine.symptomNervous System DiseasesSettore M-EDF/01 - Metodi E Didattiche Delle Attivita' Motorie030217 neurology & neurosurgeryFollow-Up Studies
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Use of Medaka Fish as Vertebrate Model to Study the Effect of Cocoa Polyphenols in the Resistance to Oxidative Stress and Life Span Extension.

2018

Oxidative stress (OS) can induce cell apoptosis and thus plays an important role in aging. Antioxidant foods protect tissues from OS and contribute to a healthier lifestyle. In this study, we described the used of medaka embryos (Oryzias latipes) to study the putative antioxidant capacity of dietary cocoa extract in vertebrates. A polyphenol-enriched cocoa extract regulated the expression of several genes implicated in OS, thereby protecting fish embryos from induced OS. The cocoa extract activated superoxide dismutase enzyme activity in embryos and adult fish tissues, suggesting a common mechanism for protection during embryonic development and adulthood. Furthermore, long-term feeding of …

0301 basic medicineAgingAntioxidantanimal structuresantioxidantEmbryo Nonmammalianmedicine.medical_treatmentOryziasLongevityOryziasmedicine.disease_causecocoa polyphenolsSuperoxide dismutase03 medical and health sciencesbiology.animalmedaka fishBotanymedicinelife span extensionAnimalsSodFlavonoidsCacaobiologyPlant ExtractsSuperoxide DismutaseCocoa ExtractVertebratefood and beveragesGene Expression Regulation DevelopmentalPolyphenolsVitamin K 3EmbryoHydrogen Peroxidebiology.organism_classificationEnzyme assayCell biologyOxidative Stress030104 developmental biologyembryonic structuresDietary Supplementsbiology.proteinFoxOGeriatrics and GerontologyOxidative stressRejuvenation research
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