Search results for "git"
showing 10 items of 7116 documents
TGF-β2 silencing to target biliary-derived liver diseases
2020
ObjectiveTGF-β2 (TGF-β, transforming growth factor beta), the less-investigated sibling of TGF-β1, is deregulated in rodent and human liver diseases. Former data from bile duct ligated and MDR2 knockout (KO) mouse models for human cholestatic liver disease suggested an involvement of TGF-β2 in biliary-derived liver diseases.DesignAs we also found upregulated TGFB2 in liver tissue of patients with primary sclerosing cholangitis (PSC) and primary biliary cholangitis (PBC), we now fathomed the positive prospects of targeting TGF-β2 in early stage biliary liver disease using the MDR2-KO mice. Specifically, the influence of TgfB2 silencing on the fibrotic and inflammatory niche was analysed on m…
Sustained virological response to interferon-alpha is associated with improved outcome in HCV-related cirrhosis: a retrospective study
2007
The effect of achieving a sustained virological response (SVR) following interferon-α (IFNα) treatment on the clinical outcomes of patients with HCV-related cirrhosis is unknown. In an attempt to assess the risk of liver-related complications, HCC and liver-related mortality in patients with cirrhosis according to the response to IFNα treatment, a retrospective database was developed including all consecutive patients with HCV-related, histologically proven cirrhosis treated with IFNα monotherapy between January 1992 and December 1997. SVR was an undetectable serum HCV-RNA by PCR 24 weeks after IFNα discontinuation. HCC was assessed by ultrasound every 6 months. Independent predictors of al…
Liver Steatosis and Fibrosis in OSA patients After Long-term CPAP Treatment: A Preliminary Ultrasound Study.
2015
In cases of morbid obesity, obstructive sleep apnea (OSA) was associated with biopsy-proven liver damage. The role of non-invasive techniques to monitor liver changes during OSA treatment with continuous positive airway pressure (CPAP) is unknown. We used non-invasive ultrasound techniques to assess liver steatosis and fibrosis in severe OSA patients at diagnosis and during long-term CPAP treatment. Fifteen consecutive patients with severe OSA (apnea hypopnea index 52.5 ± 19.1/h) were studied by liver ultrasound and elastography (Fibroscan) at 6-mo (n = 3) or 1-y (n = 12) follow-up. Mean age was 49.3 ± 11.9 y, body mass index (BMI) was 35.4 ± 6.4 kg/m(2). Adherence to CPAP was ≥5 h/night. A…
Digital Pathology Enables Automated and Quantitative Assessment of Inflammatory Activity in Patients with Chronic Liver Disease
2021
Traditional histological evaluation for grading liver disease severity is based on subjective and semi-quantitative scores. We examined the relationship between digital pathology analysis and corresponding scoring systems for the assessment of hepatic necroinflammatory activity. A prospective, multicenter study including 156 patients with chronic liver disease (74% nonalcoholic fatty liver disease-NAFLD, 26% chronic hepatitis-CH etiologies) was performed. Inflammation was graded according to the Nonalcoholic Steatohepatitis (NASH) Clinical Research Network system and METAVIR score. Whole-slide digital image analysis based on quantitative (I-score: inflammation ratio) and morphometric (C-sco…
The European NAFLD Registry: A real-world longitudinal cohort study of nonalcoholic fatty liver disease
2020
© 2020 The Author(s).
Anti-fibrotic therapy: lost in translation?
2012
While preclinical development of potential anti-fibrotics is far advanced, with numerous pharmacological targets and promising agents, almost none has entered clinical validation. Reasons are manifold, including the usually slow progression of liver fibrosis, requiring high numbers of well-stratified patients undergoing long-term treatment when conventional liver biopsy based parameters or hard liver-related endpoints are used. Importantly, there is a notorious lack of sensitive and specific surrogate markers or imaging technologies for liver fibrosis progression or regression that would permit a rapid clinical screening for potential anti-fibrotics. Nonetheless, in view of an urgent need f…
Definite and indeterminate nonalcoholic steatohepatitis share similar clinical features and prognosis : A longitudinal study of 1893 biopsy-proven no…
2021
[Background and Aim] Histological score systems may not fully capture the essential nonalcoholic steatohepatitis (NASH) features, which is one of the leading causes of screening failure in clinical trials. We assessed the NASH distribution and its components across the fibrosis stages and their impact on the prognosis and their relationship with the concept of metabolic-associated fatty liver disease (MAFLD).
La mesura de l'ús de les llengües en els mitjans telemàtics
2020
La consolidació de l'entorn digital i totes les seues modalitats de comunicació ha ampliat les possibilitats d'interacció i, per tant, els àmbits d'ús de les llengües. Com a adaptació a aquesta nova realitat, en aquesta aproximació metodològica plantegem la combinació de diferents tècniques no reactives: explotació de fonts secundàries, observació sistemàtica, i mystery shopping. Les fonts d'observació directa ens permeten mesurar de manera efectiva l'ús de les llengües en la comunicació telemàtica. Els autors ho han aplicat específicament en l'administració local i en empreses de serveis. En l'àmbit administratiu, a més, això ens ha servit per a desenvolupar un índex global de presència de…
Digital signal processing for relaxation data conversion
2005
Abstract The origins, philosophy and basic practical aspects are considered for an approach of digital data transformations for broadband dielectric relaxation spectroscopy and other relaxation experiments carrying out direct and inverse integral transforms with kernels depending on the ratio or product of arguments. The approach is based on the concept that the mentioned data transformations represent a filtering problem on a logarithmic scale allowing one to implement the transforms by digital functional filters with the logarithmic sampling. As an example, digital Kramers–Kronig transformers are considered.
Maksātnespējas prognozēšanas modeļa pielietojums Latvijas sabiedrībām ar ierobežotu atbildību
2021
Lai sadarbība starp uzņēmumiem būtu veiksmīga, katram no partneriem jābūt pārliecinātam par otra maksātspēju. Maksātnespējas prognozēšanas modeļi palīdz gūt šādu pārliecību. Izmantojot darījuma partnera deklarētos finansiālos rādītājus var gūt ieskatu tā finansiālajā stāvoklī un, pielietojot pareizi piemeklētu prognozēšanas modeli, var mēģināt savlaicīgi paredzēt iespējamo maksātnespēju. Maģistra darba mērķis ir aprobēt un pēc nepieciešamības modificēt E.Altmana Z-vērtību modeli Latvijas privāto uzņēmumu maksātnespējas paredzēšanai, salīdzināt rezultātus ar logit analīzes metodi, kā arī izstrādāt priekšlikumus modeļa plašākai pielietošanai Latvijas uzņēmējdarbības vidē. Rezultātā ar logit a…