Search results for "hdr"
showing 10 items of 140 documents
Preclinical evidence of new opioid modulators for the treatment of addiction.
2010
Addiction to opiates is one of the most severe forms of substance dependence, and despite a variety of pharmacological approaches to treat it, relapse is observed in a high percentage of subjects. New pharmacological compounds are necessary to improve the outcome of treatments and reduce adverse side effects. Moreover, drugs that act on the opioid system can also be of benefit in the treatment of alcohol or cocaine addiction. AREA COVERED BY THIS REVIEW: Recent preclinical studies of pharmacological agents for the treatment of opiate addiction (2008 to the present date).The reader will be informed of the latest drugs shown in animal models to modify dependence on opiates and the reinforcing…
Mpdz is a quantitative trait gene for drug withdrawal seizures
2004
Physiological dependence and associated withdrawal episodes can constitute a powerful motivational force that perpetuates drug use and abuse. Using robust behavioral models of drug physiological dependence in mice, positional cloning, and sequence and expression analyses, we identified an addiction-relevant quantitative trait gene, Mpdz. Our findings provide a framework to define the protein interactions and neural circuit by which this gene's product (multiple PDZ domain protein) affects drug dependence, withdrawal and relapse.
Prophylaxis of hemicrania continua: two new cases effectively treated with topiramate.
2007
Hemicrania continua (HC) is an uncommon and under-recognized primary headache disorder characterized by a strictly unilateral continuous headache of moderate intensity with possible exacerbations and associated with ipsilateral autonomic features. HC has generally a prompt and enduring response to indomethacin although 25% to 50% of treated patients develop gastrointestinal side effects. These cases pose a difficult management challenge as no other drug is consistently effective in HC. Recently 2 HC patients responsive to topiramate treatment have been reported. Here we describe 2 more patients effectively treated with topiramate. Neither reported any side effects and one had persisting res…
Adverse drug reactions in the oral cavity
2012
Several drugs may have a number of adverse reactions (ADRs) involving the oro-facial region. The dose of the drug and the time required for the reaction to take place are relevant parameters; nonetheless, ADRs mechanisms are not always known and ADRs are not always predictable since aspects other than drug pharmacodynamics and/or pharmacokinetics, as well as various interacting variables contribute to the final outcome. All tissues and many functions of the oral cavity can be affected. In particular, salivary function is fre- quently involved and hypo-salivation is the main manifestation; several mucosal lesions with different morphology (ulcerations, vesiculo- bullous lesions, white lesion…
Changing Trends in Drug Prescription and Causes of Treatment Discontinuation of First Biologic Over Ten Years in Psoriasis in the Spanish Biobadaderm…
2020
Background and objectives: Current psoriasis guidelines do not usually include recommendations about first line classical or biologic treatment. The objectives of this study were: to describe shifts in the prescription of the first biological treatment, and to compare treatment withdrawal and rates of adverse events over ten years. Material and methods: Biobadaderm registry was analyzed to describe: first biological prescription in bio-naive patients, adverse events rate and reasons for drug withdrawal comparing three periods of time (2008-2010, 2011-2014, 2015-2018). Results: Anti-TNF drugs were the most prescribed biological drug from 2008 to 2010. Ustekinumab has become the most prescrib…
Drug-Induced Respiratory Disease in Connective Tissue Diseases
2004
Publisher Summary This chapter discusses drug-induced respiratory disease in connective tissue diseases. Drug-induced lung diseases (DILDs) vary in severity from mild to life threatening. Generally, DILDs subside upon drug discontinuance, and leave permanent sequelae in a minority of patients. Less frequently, DILDs persist unabated, or progress despite drug withdrawal, requiring specific management. Drugs used in connective tissue diseases (CTDs) can produce a constellation of pulmonary and systemic reactions. These can mimic pulmonary involvement from CTD, a systemic disease, or an infection, and are difficult to prevent, predict, and diagnose. Maintaining a high index of suspicion enable…
Data service platform for sentinel-2 surface reflectance and value-added products: System use and examples
2016
This technical note presents the first Sentinel-2 data service platform for obtaining atmospherically-corrected images and generating the corresponding value-added products for any land surface on Earth (http://s2.boku.eodc.eu/). Using the European Space Agency’s (ESA) Sen2Cor algorithm, the platform processes ESA’s Level-1C top-of-atmosphere reflectance to atmospherically-corrected bottom-of-atmosphere (BoA) reflectance (Level-2A). The processing runs on-demand, with a global coverage, on the Earth Observation Data Centre (EODC), which is a public-private collaborative IT infrastructure in Vienna (Austria) for archiving, processing, and distributing Earth observation (EO) data (http://www.…
Lielbritānijas izstāšanās no Eiropas Savienības un tā ietekme uz Latvijas Republikas valstspiederīgajiem
2020
Bakalaura darbs “Lielbritānijas izstāšanās no Eiropas Savienības un tā ietekme uz Latvijas Republikas valstspiederīgajiem” ir pētījums par līdz šim nebijušu gadījumu, kad kāda no ES dalībvalstīm vēlas izstāties no ES. Bakalaura darba mērķis ir izpētīt arī analīzēt tiesiskās attiecības starp ES un Lielbritāniju, kas radušās sakarā ar ES dalībvalsts – Lielbritānijas izstāšanos no ES un tās ietekmi uz Latvijas Republikas valstspiederīgajiem. Darba uzdevumi: 1.Apzināt vēsturisko situāciju un Lielbritānijas izstāšanās ES norises tiesisko procedūru; 2.Veikt analīzi par pārejas perioda tiesisko regulējumu un tiesību aktiem, kuri būtu jāpieņem pārejas laikā; 3.Apskatīt tiesisko vīziju Lielbritānija…
Correction to: Withholding or withdrawing of life-sustaining therapy in older adults (≥ 80 years) admitted to the intensive care unit (Intensive Care…
2018
In the original publication Dr Patrick Meybohm of the Department of Anaesthesiology, Intensive Care Medicine and Pain Therapy, Frankfurt University Hospital, Frankfurt, Germany was inadvertently omitted from the list of investigators.
Lipase maturation factor 1 is required for endothelial lipase activity
2011
Lipase maturation factor 1 (Lmf1) is an endoplasmic reticulum (ER) membrane protein involved in the posttranslational folding and/or assembly of lipoprotein lipase (LPL) and hepatic lipase (HL) into active enzymes. Mutations in Lmf1 are associated with diminished LPL and HL activities ("combined lipase deficiency") and result in severe hypertriglyceridemia in mice as well as in human subjects. Here, we investigate whether endothelial lipase (EL) also requires Lmf1 to attain enzymatic activity. We demonstrate that cells harboring a (cld) loss-of-function mutation in the Lmf1 gene are unable to generate active EL, but they regain this capacity after reconstitution with the Lmf1 wild type. Fur…