Search results for "hemo"
showing 10 items of 5646 documents
Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) for Unresectable Peritoneal Metastases. Feasibility, Safety and Efficacy Outcomes
2022
Recently, a novel method for chemotherapy administration inside the abdominal cavity gained wide attention among surgical oncologists dealing with peritoneal surface malignancies. Based on laparoscopy, Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a drug delivery system designed to overcome the known hurdles of intraperitoneal chemotherapy. Preclinical data suggest that the aerosol drug that PIPAC creates and the increased intraabdominal pressure obtained during laparoscopy provide highly effective distribution of cytotoxic compounds into tumor nodules. Several studies have documented the favorable safety profile and promising clinical outcomes of repetitive PIPAC in different…
Feasible Low-Phosphorus Dietary Patterns in Maintenance Hemodialysis Patients: Need for Original Research
2020
Introduction The standard low-phosphorus diet restricts pulses, nuts, and whole grains and other high phosphorus foods to control hyperphosphatemia. We conducted a randomized controlled trial to evaluate the effectiveness, safety, and tolerability of the modified diet, which introduced some pulses and nuts, increased the use of whole grains, increased focus on the avoidance of phosphate additives, and introduced the prescription of low-biological-value protein such as bread. Methods We conducted a multicenter, pragmatic, parallel-arm, open-label, randomized controlled trial of modified versus standard diet in 74 adults on hemodialysis with hyperphosphatemia over 1 month. Biochemistry was as…
Study on the mechanism of action of antitumor photochemotherapic agents by means of docking and QSPR analysis
2008
Synthesis, characterization, and cellular investigations of porphyrin– and chlorin–indomethacin conjugates for photodynamic therapy of cancer
2021
Indomethacin is a potent non-steroidal anti-inflammatory drug (NSAID) with a strong selective inhibitor activity towards cyclooxygenase-2 (COX-2), an enzyme that is highly overexpressed in various tumour cells, being involved in tumourigenesis. Concomitantly, porphyrins have gained much attention as promising photosensitizers (PSs) for the non-invasive photodynamic therapy (PDT) of cancer. Herein, we report the design, and determine the singlet oxygen generation capacity and in vitro cellular toxicity of porphyrin- and chlorin-indomethacin conjugates (P2-Ind and C2-Ind). Both the conjugates were obtained in high yields and were characterized by 1H, 19F and 13C NMR as well as by high resolut…
Photochemotherapeutic heterocyclic agents having antiproliferative and antineoplastic activity
2012
The present invention concerns the synthesis of new analogs of angelicins, pyrrolo[3,2-h]quinoline, for the treatment of pathologie having hyperproliferative character including those having neoplastic nature. The treatment is based on the combined action of pyrrolo[3,2-h]quinolines and UV-A light, through a clinical approach defined as PUVA (psoralen-UVA light). The most important feature of these compounds is that they exert their remarkable phototoxicity without any DNA damage, which is the main origin of the side effects of the PUVA therapy
La influencia de la técnica quirúrgica en la hemorragia postamigdalectomía
2022
La complicación más frecuente de la amigdalectomía extracapsular (AE) es la hemorragia postamigdalectomía (HPA). Los factores relacionados con esta son diversos, entre los que se encuentra la técnica quirúrgica con la que se lleva a cabo. Se distinguen las técnicas frías y calientes. Entre sus indicaciones se encuentran las infecciones amigdalares de repetición, las complicaciones derivadas de estas amigdalitis y pacientes pediátricos con trastornos respiratorios del sueño (TRS). En este último grupo, una alternativa terapéutica es la amigdalectomía intracapsular (AI). Se distinguen dos tipos de HPA: primaria, que ocurre durante las primeras 24 horas, y secundaria (HPAt), que ocurre tras la…
Dental treatment of patients with coagulation factor alterations: An update
2007
Hemostasia is a defense mechanism that protects vascular integrity, avoids blood loss, and maintains blood fluidity throughout the circulatory system. The biochemical processes leading to blood clot formation are complex, and alterations can appear at any point within the chain of events. While a range of alterations can affect the coagulation factors, some are more common than others in the general population, including congenital (hemophilia A and B, Von Willebrand’s disease) and acquired disorders (anticoagulant drugs). Such diseases require special consideration in the context of dental treatment, and therefore must be known to dental professionals. Interconsultation with the hematologi…
Pronóstico de la hemorragia subaracnoidea espontánea aneurismática y su correlación con escalas de gravedad, escalas de calidad de vida y tratamiento…
2015
La hemorragia subaracnoidea (HSA) corresponde a uno de los tipos de hemorragia intracraneal en el que se produce una extravasación de sangre en el espacio subaracnoideo o leptomeníngeo. La causa más frecuente es el traumatismo craneoencefálico y en segundo lugar el sangrado espontáneo. La HSA primaria o espontánea se produce, con mayor frecuencia, por la ruptura de una aneurisma cerebral. La HSA es el subtipo de ictus menos frecuente pero es el que cualitativamente mayor morbimortalidad produce. La carga sociosanitaria que representa es aún más pesada dado que incide en un porcentaje relevante de los casos sobre personas jóvenes, previamente sanas y completamente independientes. A pesar de …
Politraumas protokolu pielietojums radiogrāfera praksē
2018
Darba autors: Evija Perse. Bakalaura darbs. „Politraumas protokolu pielietojums radiogrāfera praksē”. Izstrādāts Latvija Universitātē, Medicīnas fakultātē, Rīgā, 2018.gadā. Darba mērķis ir noskaidrot politraumas protokola pielietojumu, veicot datortomogrāfijas izmeklējumu. Lai sasniegtu pētījuma mērķi, tiek izvirzīti sekojoši darba uzdevumi: 1.apkopot un analizēt medicīnisko literatūru par traumu cēloņiem, mehānismu, veidiem; 2.izpētīt un analizēt pieņemtos standartus par radioloģisko izmeklējumu protokoliem politraumas pacientiem; 3.noskaidrot biežāk pielietotos izmeklējumu protokolus politraumas gadījumā; 4.izveidot datu analīzes kritērijus, lai apzinātu protokolu izvēli; 5.apkopot un ana…
Tratamiento no farmacológico del dolor crónico en pacientes con hemofilia: eficacia de un programa de fisioterapia combinado con terapia cognitivo-co…
2021
Más de la mitad de las personas con hemofilia (PCH) grave y artropatía severa sufren dolor crónico y éste repercute sobre su funcionalidad, calidad de vida y kinesiofobia. Esto, a su vez, influye en el bienestar psicológico y emocional del paciente lo que puede empeorar a su vez su condición física dando lugar a un círculo vicioso. Aunque esto es un problema, no existen tratamientos específicos para el manejo de esta condición. Por ello, el objetivo de esta tesis es evaluar los efectos de un protocolo combinado de fisioterapia y terapia cognitivo conductual (TCC) administrados por un fisioterapeuta y un psicólogo respectivamente en PCH severa, artropatía y dolor crónico, así como los efecto…