Search results for "hole"

Dysfunctional High-Density Lipoproteins Are Associated With a Greater Incidence of Acute Coronary Syndrome in a Population at High Cardiovascular Risk

2020

Background: Studies have failed to establish a clear link between high-density lipoprotein (HDL) cholesterol and cardiovascular disease, leading to the hypothesis that the atheroprotective role of HDL lies in its biological activity rather than in its cholesterol content. However, to date, the association between HDL functional characteristics and acute coronary syndrome has not been investigated comprehensively. Methods: We conducted a case-control study nested within the PREDIMED (Prevención con Dieta Mediterránea) cohort, originally a randomized trial in which participants followed a Mediterranean or low-fat diet. Incident acute coronary syndrome cases (N=167) were individually matched …

Treatment of primary hypercholesterolemia: comparison of the effectiveness of different statins

2000

Nelipīdu riska faktoru izvērtējums pacientiem ar ģimenes hiperholesterolēmiju

2018

Pamatojums: Ģimenes Hiperholesterinēmija (ĢH) raksturojas ar paaugstinātu zema blīvuma lipoproteīnu holesterīna (ZBL-H) koncentrāciju, kas ievērojami paaugstina agrīnu kardiovaskulāro slimību (KVS) attīstības risku. Papildus (ZBL-H) citu, ar lipīdiem nesaistītu, riska faktoru nozīmīgai ietekmei uz KVS attīstības risku, ir svarīga to identifikācija un kontrole jau dzīves laikā vai kopš bērnības. Mērķis: Raksturot un identificēt biežākos ar lipīdiem nesaistītus riska faktorus, kas var veicināt KVS attīstību pacientiem ar ĢH, kas tādējādi varētu palīdzēt akcentēt nozīmi to turpmākai kontrolei. Materiāli un metodes: Šī ir retrospektīva kohorta analīze pacientu grupai ar ticamu vai drošu ĢH diag…

On the location of the supermassive black hole in CTA102

2015

Relativistic jets in active galactic nuclei represent one of the most powerful phenomena in the Universe. They form in the surroundings of the supermassive black holes as a by-product of accretion onto the central black hole in active galaxies. The flow in the jets propagates at velocities close to the speed of light. The distance between the first part of the jet that is visible in radio images (core) and the black hole is still a matter of debate. Only very-long-baseline interferometry observations resolve the innermost compact regions of the radio jet. Those can access the jet base, and combining data at different wavelenghts, address the physical parameters of the outflow from its emiss…

Correlations of blood selenium with hematological parameters in West German adults.

1988

The serum selenium and the whole blood selenium of 72 healthy persons (47 women, 25 men) was determined. There exist sex specific differences of the whole blood selenium between men (98 +/- 19 micrograms Se/L) and women (89 +/- 17 micrograms Se/L). The serum selenium did not show sex specific differences, but sex specific differences are found if the total amount of extracellular selenium is calculated by correction of the serum selenium with the hematocrit. Women have more extra-cellular selenium/L whole blood (40 +/- 8 micrograms Se) than men (36 +/- 7 micrograms Se). Men have more intraerythrocyte selenium (cellular selenium = 67 +/- 14 micrograms Se) in one L whole blood than women (52 …

Mipomersen: a lipid-lowering agent with a novel mechanism of action

2013

“...mipomersen is a ... valuable alternative to apheresis for patients with heterozygous familial hypercholesterolemia.”

Preparation of 2,3-seco-5α-cholestane-2,3-diol and 4α-methyl-2,3-seco-5α-cholestane-2,3-diol and its reactions with o-nitrophenyl selenocyanate

1984

The reaction of 2,3-seco-5 alpha-cholestane-2,3-diol and 4 alpha-methyl-2,3-seco-5 alpha-cholestane-2,3-diol with o-nitrophenyl selenocyanate was studied. The diols were synthesized from cholesterol.

Synthesis and preliminary in vivo evaluation of well-dispersed biomimetic nanocrystalline apatites labeled with positron emission tomographic imaging…

2015

In recent years, biomimetic synthetic apatite nanoparticles (AP-NPs), having chemical similarity with the mineral phase of bone, have attracted a great interest in nanomedicine as potential drug carriers. To evaluate the therapeutic perspectives of AP-NPs through the mechanisms of action and organs they interact with, the noninvasive monitoring of their in vivo behavior is of paramount importance. To this aim, here the feasibility to radiolabel AP-NPs ("naked" and surface-modified with citrate to reduce their aggregation) with two positron emission tomographic (PET) imaging agents ([F-18]NaF and Ga-68-NO(2)AP(BP)) was investigated. [F-18]NaF was used for the direct incorporation of the radi…

Cholesterol protein interaction - the issue of specificity

2009

Bifunctional Acid-Base Catalysis

2011

Acid-base catalysis with bifunctional catalysts is a very prominent catalytic strategy in both small-molecule organocatalysts as well as enzyme catalysis. In both worlds, small-molecule catalysts and enzymatic catalysis, a variety of different general acids or hydrogen bond donors are used. In this chapter, important parallels between small molecule catalysts and enzymes are discussed, and a comparison is also made to the emerging field of frustrated Lewis pair catalysis.