Search results for "imprint"
showing 10 items of 194 documents
Screening of oxazepine indole enantiomers by means of high performance liquid chromatography with imprinted polymer stationary phase.
2004
Chromatographic enantiomer separations of different oxazepine indole derivatives were performed using a molecularly imprinted polymer. A 5aR,12R,13S-trans-6,6-dimethyl-12,13-dihydro-6H-5a, 1 3-methanoindolo[2,1-b][1,3]naphthoxazepine-12-carboxamide enantiomerderivative was used as a template and the resultant polymer has shown enantiomer recognition for series of template related compounds. The mechanistic description of the chiral discrimination process is scrutinised, comparing the discrimination between the different conformations and substituents of the oxazepine indoles.
Health outcomes of children born after IVF/ICSI: a review of current expert opinion and literature
2014
The Sixth Evian Annual Reproduction (EVAR) Workshop Group Meeting was held to evaluate the impact of IVF/intracytoplasmic sperm injection on the health of assisted-conception children. Epidemiologists, reproductive endocrinologists, embryologists and geneticists presented data from published literature and ongoing research on the incidence of genetic and epigenetic abnormalities and congenital malformations in assisted-conception versus naturally conceived children to reach a consensus on the reasons for potential differences in outcomes between these two groups. IVF-conceived children have lower birthweights and higher peripheral fat, blood pressure and fasting glucose concentrations than …
Ovulation induction and epigenetic anomalies
2013
In this systematic review of ovulation induction and epigenetic control, studies mainly done in the mouse model highlight how hormone treatments may be prejudicial to the epigenetic reprogramming of gametes as well as early embryos. Moreover, the hormone protocols used in assisted reproduction may also modify the physiologic environment of the uterus, a potential link to endometrial epigenetic disturbances. At present, the few available data in humans are insufficient to allow us to independently determine the impact of a woman's age and infertility problems and treatment protocols and hormone doses on such processes as genomic imprinting.
Mechanisms involved in the transmission of epigenetic deregulation : analyses of transmission in human sperm
2018
The notion that environmental exposure can be memorized and promote epimutation (defined as defects on DNA methylation) raises the question of possible epigenetic transgenerational transmission in humans. To address whether an epimutation could be transmitted in humans, we pursued two axes. First, the evaluation of intergenerational transmission in the family of a Silver-Russell patient has shown, for the first time, the efficiency of epigenetic reprogramming in humans, specifically on imprinted regions. Indeed, no imprinted defect on causal H19/IGF2 locus was detected in the patient’s spermatozoa or in the DNA of his daughter. The second axis was to assess the presence of sperm epimutation…
Molekulāri imprintētu polimēru sintēze un sorbcijas īpašības vienlaicīgai kateholamīnu un to metabolītu atdalīšanai no bioloģiskajiem paraugiem
2021
Molekulāri imprintētu polimēru sintēze un sorbcijas īpašības vienlaicīgai kateholamīnu un to metabolītu atdalīšanai no bioloģiskajiem paraugiem. Šilaks A., zinātniskais vadītājs Dr. chem., vadošais pētnieks Antons Podjava. Maģistra darbs, 43 lappuses, 12 attēli, 4 tabulas, 26 literatūras avoti, 15 pielikumi. Latviešu valodā. Darbā ir apkopota informācija par molekulāri imprintētiem polimēriem, to sorbcijas īpašībām un izmantošanas iespējām. Eksperimentālajā daļā tika veikta molekulāri imprintētu polimēru sintēze un demonstrēts to pielietojums kateholamīnu un to metabolītu izdalīšanai no asins plazmas paraugiem, izmantojot cietfāzes ekstrakciju.
Determination of non-steroidal anti-inflammatory drugs in water and urine using selective molecular imprinted polymer extraction and liquid chromatog…
2016
Abstract A selective solid-phase extraction was employed for the improvement of the determination of non-steroidal anti-inflammatory drugs (NSAIDs) in continental water and urine samples. Ketoprofen, naproxen, diclofenac, and ibuprofen were selected as target analytes due to they are the most frequently administered and consumed NSAIDs. These compounds were extracted using molecular imprinted polymers and determined by liquid chromatography with diode array (DAD), and tandem-mass spectrometry (MS–MS) detectors. Performance of DAD and MS–MS detectors was evaluated throughout this study. The obtained limits of quantification, after a 50-fold preconcentration solid-phase extraction, varied fro…
The application of molecular imprinting technology to solid phase extraction
2001
In parallel to a long lasting search for universal multi-purpose sorbents, the area of solid phase extraction (SPE) is recently experiencing a rapid development of new types of tailor-made class specific or compound-specific sorbents which are designed to respond to the increasing demand for selectivity and efficiency in sample clean-up prior to quantification. An important issue here is the enrichment and clean-up of complex samples, such as environmental waters, sediments, biofluids and foodstuffs prior to detection. This because the analyte is often present in low concentration in a complex mixture of similar compounds and therefore needs to be isolated and enriched in order to be detect…
Pre-conception maternal helminth infection transfers via nursing long-lasting cellular immunity against helminths to offspring
2019
Mothers transfer immune cells via breastfeeding to provide offspring with long-term protection from parasitic infection.
Embodying in Paint: Series by Louis Le Brocquy
2014
International audience
Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency
2016
S-adenosylhomocysteine hydrolase (AHCY) deficiency is a rare autosomal recessive disorder in methionine metabolism caused by mutations in the AHCY gene. Main characteristics are psychomotor delay including delayed myelination and myopathy (hypotonia, absent tendon reflexes etc.) from birth, mostly associated with hypermethioninaemia, elevated serum creatine kinase levels and increased genome wide DNA methylation. The prime function of AHCY is to hydrolyse and efficiently remove S-adenosylhomocysteine, the by-product of transmethylation reactions and one of the most potent methyltransferase inhibitors. In this study, we set out to more specifically characterize DNA methylation changes in blo…