Search results for "inclusion"
showing 10 items of 891 documents
Neurochemical and morphological studies on demyelination in multiple sclerosis with special reference to etiological aspects.
1972
Light microscopic studies were used as control for neurochemical studies and these showed that some micro plaques could be found also in areas which were normal on visual inspection. Also foreign cell infiltrates were found outside any clear plaque material. The number of these cells did not correlate with other findings like lipid or enzyme chemistry. In electronmicroscopic studies astrocytes demonstrated most lysosomes and phagocytosis of myelin. This increased lysosomal reaction was demonstrated also in biochemical analyses performed on MS biopsy specimens. Occasional nuclear changes like inclusion bodies and protrusion of inner nuclear membrane were observed suggesting some exogenous, p…
Neonatal form of nemaline myopathy, muscle immaturity, and a microvascular injury.
1990
An infant with a neonatal form of nemaline myopathy showed ultrastructural features of muscle immaturity. Immaturity was characterized by an abnormal presence of myotubes, as well as cells in clusters within a common basement membrane and a great number of satellite cells adhering to very small muscle fibers. In addition, degenerative changes and a severe microvascular lesion were observed. The pathologic findings in the muscle of this patient were those of neonatal nemaline myopathy complicating severe microvascular injury, possibly induced by an unknown toxic agent. ( J Child Neurol 1990;5:122-126).
Surplus protein myopathies.
2001
Abstract Certain muscular dystrophies are marked by absence or reduction of mutant proteins, foremost dystrophinopathies and sarcoglycanopathies. Conversely, other sporadic and familial neuromuscular conditions are marked by a surplus of proteins present in a granular or filamentous form, such as desmin-related myopathies, actinopathy and, perhaps, hyaline body myopathy. This emerging group of congenital myopathies is clinically, immunohistochemically, and genetically diverse. Clinically, early- and late-onset diseases with variable courses are described. Immunohistochemically, mutant gene-related and other proteins have been identified by immunohistochemistry. Mutations in the desmin and α…
Myopathology of non-infectious inflammatory myopathies - the current status.
2007
Besides the classical inflammatory myopathies (IM), dermatomyositis (DM), polymyositis, and inclusion body myositis, the much larger spectrum of IM includes focal and nodular myositis, granulomatous myositis, macrophagic myofasciitis, graft vs. host myositis, eosinophilic myositis, and other immune-associated conditions, some of them only recently described. In addition, paraneoplastic, statin-induced and critical illness myopathies have been considered immune-associated IM. Infectious, i.e., bacterial, viral, and parasitic IM are much less frequent in the northern hemisphere. In IM, muscle biopsy is an essential diagnostic procedure to initiate therapy. The myopathological spectrum encompa…
Desmin-related neuromuscular disorders
1995
Desmin, the intermediate filament protein of skeletal muscle fibers, cardiac myocytes, and certain smooth muscle cells, is a member of the cytoskeleton linking Z-bands with the plasmalemma and the nucleus. The pathology of desmin in human neuromuscular disorders is always marked by increased amounts, diffusely or focally. Desmin is highly expressed in immature muscle fibers, both during fetal life and regeneration as well as in certain congenital myopathies, together with vimentin. Desmin is also enriched in neonatal myotonic dystrophy and small fibers in infantile spinal muscular atrophy. Focal accretion of desmin may be twofold, in conjunction with certain inclusion bodies, cytoplasmic an…
Primary desminopathies.
2007
• Introduction • Desmin is an essential component of the extrasarcomeric cytoskeleton in striated muscle cells • Distal myopathy,cardiac arrhythmias,cardiomyopathy:classical criteria of primary desminopathies • Sub-sarcolemmal and cytoplasmic desmin-positive protein aggregates:the morphological hallmark of primary and secondary desminopathies • The spectrum of pathogenic desmin gene mutations • The molecular pathogenesis of primary desminopathies: some answers gained,but even more questions raised • Diagnostic work-up to distinguish primary from secondary desminopathies • Treatment and clinical management of primary desminopathy patients Abstract Mutations of the human desmin gene o…
Granular nuclear inclusion body disease: Fine structure of tibial muscle and sural nerve
1985
Fine granular (hyaline) intranuclear inclusion bodies were found in perivascular cells of a muscle and a sural nerve biopsy from a 32-year-old woman with slowly progressive motor disturbances. The hyaline nuclear inclusion bodies could be distinguished from other intranuclear hyaline inclusions by their granularity, the size of the granules (approximately 5-15 nm), and the positive iron staining reaction. They were not seen in muscle fibers or Schwann cells. Because of these apparently pathognomonic structural features the patient appears to present a condition that has not been described before.
Il gioco del teatro e la pratica educativa. Percorsi pedagogici per comunicare l'integrazione.
2014
Il contributo intende proporre una ricognizione delle teorie, delle linee evolutive, dei riferimenti legislativo-normativi della Pedagogia speciale nonché una analisi dei piani di intervento (metodologie, strategie e tecniche) per l’integrazione della diversabilità in rapporto all’individuazione dei bisogni educativi e delle competenze reali dei soggetti coinvolti. Particolare attenzione sarà posta all’uso della pratica teatrale, da un lato come dispositivo storico-culturale (Teatro dell’Oppresso, Teatro Scuola, ecc.), dall’altro come strategia di riallineamento sensoriale-espressivo, nonché come strumento dialogico in grado di armonizzare le diverse abilità e di facilitare la relazione tra…
From Exclusion to Inclusion: Deaf and Hard-of-Hearing Students in the Spanish University
2008
The educational inclusion of disabled people constitutes one of the most relevant educational and pedagogical innovations in the past decades. This article analyses such inclusion at the university level choosing students with deafness as a representative and extrapolative sample. After specifying the main limitations and needs for this group of students, the study revises the solutions put forward by the current legislation and it details in depth, by way of a comparative study, the services provided now by the newly created University Services for the Integration of students with special educational needs. The study points out conclusively some proposals for the future?principles, strateg…
Key challenges for Latvian teachers in mainstream schools: a basis for preparing teachers for inclusion
2010
This paper analyses current research in Latvia to identify key issues related to inclusive education, special education and social pedagogy. A review of Latvian literature since 2004 was undertaken to determine what is known about special and inclusive education, how it is reflected in various research papers and how it related to the current situation in schools. Key findings suggest that teachers need to be better informed about the potential of inclusion. They need to be prepared to teach children with diverse educational needs in a changing educational landscape. Teacher education for inclusion is identified as a 21st-century priority in Latvia.