Search results for "informatics"
showing 10 items of 2542 documents
Kondrat'eva ligation: Diels-Alder-based irreversible reaction for bioconjugation.
2014
International audience; Diversification of existing chemoselective ligations is required to efficiently access complex and well-defined biomolecular assemblies with unique and valuable properties. The development and bioconjugation applications of a novel Diels-Alder-based irreversible site-specific ligation are reported. The strategy is based on a Kondrat'eva cycloaddition between bioinert and readily functionalizable 5-alkoxyoxazoles and maleimides that readily react together under mild and easily tunable reaction conditions to afford a fully stable pyridine scaffold. The potential of this novel bioconjugation is demonstrated through the preparation of fluorescent conjugates of biomolecul…
Optimisation et implémentation de méthodes bio-inspirées d'extraction de caractéristiques pour la reconnaissance d'objets visuels
2016
Industry has growing needs for so-called “intelligent systems”, capable of not only ac-quire data, but also to analyse it and to make decisions accordingly. Such systems areparticularly useful for video-surveillance, in which case alarms must be raised in case ofan intrusion. For cost saving and power consumption reasons, it is better to perform thatprocess as close to the sensor as possible. To address that issue, a promising approach isto use bio-inspired frameworks, which consist in applying computational biology modelsto industrial applications. The work carried out during that thesis consisted in select-ing bio-inspired feature extraction frameworks, and to optimize them with the aim t…
Advanced 3D movement analysis algorithms for robust functional capacity assessment.
2017
SummaryObjectives: We developed a novel system for in home functional capacities assessment in frail older adults by analyzing the Timed Up and Go movements. This system aims to follow the older people evolution, potentially allowing a forward detection of motor decompensation in order to trigger the implementation of rehabilitation. However, the pre-experimentations conducted on the ground, in different environments, revealed some problems which were related to KinectTM operation. Hence, the aim of this actual study is to develop methods to resolve these problems.Methods: Using the KinectTM sensor, we analyze the Timed Up and Go test movements by measuring nine spatio-temporal parameters, …
Whole mirror duplication-random loss model and pattern avoiding permutations
2010
International audience; In this paper we study the problem of the whole mirror duplication-random loss model in terms of pattern avoiding permutations. We prove that the class of permutations obtained with this model after a given number p of duplications of the identity is the class of permutations avoiding the alternating permutations of length p2+1. We also compute the number of duplications necessary and sufficient to obtain any permutation of length n. We provide two efficient algorithms to reconstitute a possible scenario of whole mirror duplications from identity to any permutation of length n. One of them uses the well-known binary reflected Gray code (Gray, 1953). Other relative mo…
Approche préventive de la qualité des données d'importation dans le contexte de la protéomique clinique
2011
International audience; Dans le domaine biomédical, la protéomique est confrontée à des sources de données de plus en plus nombreuses et à des volumes de données très importants du fait de la multiplication des technologies dites à haut débit. L'hétérogénéité de la provenance des données implique de fait une hétérogénéité dans la représentation et le contenu de ces données. Les données peuvent aussi se révéler incorrectes ce qui engendre des erreurs sur les conclusions des expériences protéomiques. Notre approche a pour objectif de garantir la qualité initiale des données lors de leur importation dans un système d'information dédié à la protéomique. Elle est basée sur le couplage entre des …
CeLL, an agent based model for exploring the spatial influence influence of climate change on Lobesia botrana population dynamics
2016
International audience; The European Grapevine moth (Lobesia botrana) is one of the most noxious vineyard-pests in the European and Mediterranean area. Its larvae feed on grapevine flowers and berries, and usually cause considerable damage, also by facilitating saphrophytic infections to berries.The biology of L. botrana has been investigated since the 80s. A number of studies has tested its physiology and behaviour in experimental conditions (Hurtrel et Thiéry 1999), in field conditions (Stockel et al. 1994), and using mathematical modelling techniques. Whereas the modelling approaches that have been proposed in the literature are hetereogeneus they generally focus on the phenology and pop…
Analysis of headspace of flavour compounds using PTR-ToF Mass Spectrometry: optimisation of acquisition parameters
2011
National audience
In silico study of correspondences between odors descriptions linked to common features of aromas compounds
2014
The first step of odor detection and discrimination of structurally diverse odorants depends of their interactions with olfactory receptors (ORs) [1], whereas the perception of odors quality results from a combinatorial coding [2], whose identification still remains a major challenge. Recently, Martinez-Mayorga et al. demonstrated that odor description can be successfully analyzed using a metric approach by performing a descriptive analysis of the Flavor Base database (http://www.leffingwell.com, version 2010) [3]. The current version Flavor Base (9th edition, 2013) is one of the largest collections of flavor molecules (4226 molecules). We extracted 3508 molecules for which the described od…
Decoding sweet taste from chemical structures
2019
International audience
L'annuaire des Centres de Ressources Biologiques français
2011
International audience