Search results for "interpretation"
showing 10 items of 1061 documents
Structural, chemical topological, electrotopological and electronic structure hypotheses.
2003
The first important hypothesis in the prediction of properties of synthesized molecules is the structural hypothesis. In the study of drug-receptor interactions, the case where the three-dimensional structure of the receptor is known allows the application of molecular simulation and energy calculations to estimate the binding affinity for a proposed series of compounds. The chemical topological hypothesis permits the description of molecular structures without using concepts such as force or energy. These notions would not be as dominant as supposed since they should be able to be deduced from topology. Although topological descriptors are able to describe specific physicochemical properti…
Nucleotide's bilinear indices: Novel bio-macromolecular descriptors for bioinformatics studies of nucleic acids. I. Prediction of paromomycin's affin…
2009
A new set of nucleotide-based bio-macromolecular descriptors are presented. This novel approach to bio-macromolecular design from a linear algebra point of view is relevant to nucleic acids quantitative structure-activity relationship (QSAR) studies. These bio-macromolecular indices are based on the calculus of bilinear maps on Re(n)[b(mk)(x (m),y (m)):Re(n) x Re(n)--Re] in canonical basis. Nucleic acid's bilinear indices are calculated from kth power of non-stochastic and stochastic nucleotide's graph-theoretic electronic-contact matrices, M(m)(k) and (s)M(m)(k), respectively. That is to say, the kth non-stochastic and stochastic nucleic acid's bilinear indices are calculated using M(m)(k)…
La questione del confine italo-francese sul Monte Bianco
2020
Even though the common interest of France and Italy in relation to their Alpine border should be enhancing co-operation on cross-border issues (such as improving climate change adaptation as well as preventing and managing risks) a dispute on the delimitation of the border in the area around Monte Bianco has arisen in last years. As any other international dispute on territorial borders, it presents three different plans of analysis: the interpretation of boundary treaties and their official maps; the legal weight of “other” maps; the relationship between the boundary treaty and subsequent practice of the Parties (above all the relevance of effectivités). This article shortly discusses thes…
‘Zeitgeist’and minority influence—where is the causality: A comment on Clark (1990)
1995
Does the mood of the time (Zeitgeist) facilitate the influence minorities are able to exercise, or is it itself a direct product of minority influence ? It is argued, from a social psychological definition of the minority-majority relation, that the former interpretation fails to explain many of the observed effects and in particular the conversion effect. A model is offered that is consistent with the second interpretation.
Stochastic Nonlinear Time Series Forecasting Using Time-Delay Reservoir Computers: Performance and Universality
2014
International audience; Reservoir computing is a recently introduced machine learning paradigm that has already shown excellent performances in the processing of empirical data. We study a particular kind of reservoir computers called time-delay reservoirs that are constructed out of the sampling of the solution of a time-delay diFFerential equation and show their good performance in the forecasting of the conditional covariances associated to multivariate discrete-time nonlinear stochastic processes of VEC-GARCH type as well as in the prediction of factual daily market realized volatilities computed with intraday quotes, using as training input daily log-return series of moderate size. We …
Il rigo musicale in fondo alla 'Bataille d'Annezin' e i dispositivi di chiusura della lassa epica
2015
The discovery, made by E. Langlois in 1910, of a notated musical staff at the end of a little-known parodic laisse probably written within the 13th century by an otherwise unknown Thomas de Bailleul (MS London, BL, Royal 20 A XVII) immediately raised the interest of medieval musicologists, who have debated its function and interpretation until recent times, whereas romance philologists haven’t payed due attention to this intriguing and unique musical evidence, undoubtedly related to an Old French chanson de geste. In this paper I shall defend G. Schläger’s forgotten hypothesis that the musical staff could well represent a vocal-ized ‘short line’ (petit vers), arguing that this question shou…
Surrogate Data Analysis for Assessing the Significance of the Coherence Function
2004
In cardiovascular variability analysis, the significance of the coupling between two time series is commonly assessed by setting a threshold level in the coherence function. While traditionally used statistical tests consider only the parameters of the adopted estimator, the required zero-coherence level may be affected by some features of the observed series. In this study, three procedures, based on the generation of surrogate series sharing given properties with the original but being structurally uncoupled, were considered: independent identically distributed (IID), Fourier transform (FT), and autoregressive (AR). IID surrogates maintained the distribution of the original series, while …
Diffusion of naltrexone across reconstituted human oral epithelium and histomorphological features
2006
Abstract In transbuccal absorption a major limitation could be the low permeability of the mucosa which implies low drug bioavailability. The ability of naltrexone hydrochloride (NLX) to penetrate a resembling histologically human buccal mucosa was assessed and the occurrence of any histomorphological changes observed. We used reconstituted human oral (RHO) non-keratinised epithelium as mucosal section and a Transwell diffusion cells system as bicompartmental model. Buccal permeation was expressed in terms of drug flux ( J s ) and permeability coefficients ( K p ). Data were collected using both artificial and natural human saliva. The main finding was that RHO does not restrain NLX permeat…
Information in the aspect of security threats and challenges
2019
INFORMATION IN THE ASPECT OF SECURITY THREATS AND CHALLENGESIn the article, the author describes the driving force behind deliberate informational activities. He pays particular attention to the current security situation in the information dimension. Existing systems in the area of security management should be resistant to disinformation and informational operations. There is no room for the freedom of interpretation of the information acquired since every decision results in the actions of people, therefore it requires accuracy and caution. This issue takes on a special dimension when it concerns the state, because this environment contains specific features such as a changing environmen…
El formalismo interpretativo y el iusnaturalismo actual: la posición de John Finnis | The Interpretive Formalism and the Current Iusnaturalism: The P…
2014
Resumen: Hoy podemos ver un resurgimiento de las tendencias formalistas en la interpretación de reglas jurídicas. Este resurgimiento aparece en los campos tanto del Positivismo jurídico como del Iusnaturalismo. La finalidad de estos movimientos es ética y política: la defensa del imperio de la ley. Un ejemplo de esta actitud formalista es la teoría de John Finnis. Pero el formalismo no resuelve todos los problemas. Incluso desde el punto de vista de una teoría de la decisión judicial no decisionista, la interpretación jurídica necesita la ayuda de herramientas hermenéuticas no formales para completar su función. Abstract: Today, we can see a revival of formalist tendencies in the interpre…