Search results for "locu"
showing 10 items of 751 documents
Spectroscopic axonal damage of the right locus coeruleus relates to selective attention impairment in early stage relapsing-remitting multiple sclero…
2003
Summary Lower levels of N-acetylaspartate (NAA), a marker of axonal damage, have been found in the normal-appearing white matter (NAWM) of relapsing-remitting multiple sclerosis (RRMS) patients with low physical disability. However, its relation to the clinical status of these patients remains unclear. We explored the association between NAA levels [normalized to creatine (Cr), NAA/Cr] and a cognitive feature that is not measured by the standard scales that address functional disability [e.g. Expanded Disability Scale Score (EDSS)] in early RRMS. Given that a considerable number of RRMS patients present attentional dysfunction early in the disease and assuming a functional-anatomical orient…
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.
2009
Context Echocardiographic measures of left ventricular (LV) structure and function are heritable phenotypes of cardiovascular disease. Objective To identify common genetic variants associated with cardiac structure and function by conducting a meta-analysis of genome-wide association data in 5 population-based cohort studies (stage 1) with replication (stage 2) in 2 other community-based samples. Design, Setting, and Participants Within each of 5 community-based cohorts comprising the EchoGen consortium (stage 1; n = 12 612 individuals of European ancestry; 55% women, aged 26-95 years; examinations between 1978-2008), we estimated the association between approximately 2.5 million single-nuc…
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol
2012
Serum lipid levels have been associated with cardiovascular diseases, metabolic syndrome and type II diabetes (Kannel et al., 1961; Miller & Miller, 1975; Pilia et al., 2006). Variation in lipids levels is highly influenced by heritable factors (Friedlander et al., 1997) and 95 loci have already been associated with levels of high density lipoprotein (HDL) cholesterol, low density lipoprotein (LDL) cholesterol, triglycerides (TG) and total cholesterol (TC) in numerous study samples and replicated in various populations using genome-wide approaches (Aulchenko et al., 2008; Kathiresan et al., 2008; Kooner et al., 2008; Teslovich et al., 2010; Willer et al., 2008). However, the genetic associa…
A questionnaire assessing women's care needs related to gynaecological cancer screening: development of the GCSCNS.
2013
Abstract Objective To identify women's care needs concerning cancer screening and to develop an instrument suitable for measuring them – the Gynaecological Cancer Screening Care Needs Scale (GCSCNS). We hypothesized that it is possible: (a) to explore care needs and to develop reliable subscales of them, (b) to rank these needs in order of importance, and (c) to detect determinants of these needs (age, social status, marital status, health locus of control) and these need scores. Study design A questionnaire was developed based on the relevant literature, interviews conducted with gynaecological patients, and a consultation with 18 experts. The questionnaire listed 58 items addressed to phy…
Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal
2003
Epidemiological data suggest that some genetic determinants of Alzheimer's disease (AD) might reside in those polymorphisms for the immune system genes that regulate immune inflammatory responses, such as the major histocompatibility complex (MHC). Therefore, MHC polymorphisms have been the focus of a large number of AD association studies. Class Ia, Ib (hemochromatosis gene (HFE)), class II and class III (complement, tumour necrosis factor and heat shock proteins) alleles have been studied. Nearly every positive result has been followed by several studies that have failed to replicate it or that have contradicted it. Several factors, including methodological biases, might explain these dis…
2021
Gambling may range from being a recreational leisure activity to a behavioral addiction. A rising number of gamblers experience adverse consequences from gambling, termed problem gambling, which may become a challenge for the individual and society. With the present research, we aimed to investigate the correlates of problem gambling. We used a large sample of more than 12,500 individuals (46% male, Mage = 48, SDage = 18) from the Household, Income, and Labour Dynamics in Australia (HILDA) Survey and analyzed sociodemographic and personality variables (Big Five, locus of control) as well as the extent of problem gambling. Findings showed that male sex and a lower level of education were rel…
PSYCHOLOGY STUDENTS PERSONALITY TRAITS AND MOTIVATION TO CHOOSE STUDIES
2016
The sample consisted of 83 first course academic and professional psychology program students aged 18-43 years. Research instruments: 1) Demographic survey; 2) BFI (Big Five Inventory, Benet – Martinez & John, 1998), adapted version in Latvian (Austers, 2007); 3) The assessment of psychology studies motivation. Key findings: The most important motivating factors for psychology studies in this sample are interest in psychology and the desire to help. Personality traits are related to the choice of profession motives: Agreeableness and Conscientiousness are positively correlated with the desire to help, Extroversion with a sense of capability for the profession, Neuroticism - with a uncer…
La partícula modal doch entre el modo oracional declarativo e interrogativo y sus equivalentes en español
1997
En este artículo se lleva a cabo un estudio lingüístico-contrastivo de la partícula modal (en adelante: PM) alemana doch en oraciones declarativas e interrogativas y sus equivalentes en español, cuyo sistema carece de una clase lexemática de PMs (Modalpartikeln) bien determinada como en alemán. Las lenguas románicas, como el francés (Weydt, 1969), el españ,ol (Zierer, 1978) o el catalán, carecen en general de PMs como grupo lexemático con una función común. Pero en las lenguas en las que no se puede establecer una clase lexemática equivalente a las PMs alemanas también podemos hallar recursos suficientes para expresar los significados aportados por ellas.
Las partículas modales alemanas y la traducción cero: el caso de denn
2004
La traducción de las partículas modales (en adelante: PM) alemanas es un fenómeno que se ha tratado ampliamente en trabajos contrastivos de los años 90, en los que la búsqueda de equivalentes constituyó el objetivo principal. Esta búsqueda, si no ha sido infructuosa, no ha dado siempre los resultados esperados, aunque el inventario de equivalentes en español ha crecido considerablemente. Sin embargo, junto a los equivalentes hay muchos ejemplos en que la PM alemana no se traduce o contextos en que el equivalente no parece siempre apropiado. En esta artículo se expondrán algunos medios de traducción para las PM alemanas, los equivalentes propuestos y sus condiciones de uso en los contextos e…
¿Es Hauptsache un marcador del discurso?
2021
La capacidad de operar al margen de la sintaxis oracional no es exclusiva de las partículas discursivas. También se halla en ciertas palabras y construcciones gramaticales que pueden expresar funciones que superan los límites de las clases a las que pertenecen, como la conexión, la modalización o la estructuración informativa. Este trabajo indaga sobre la cláusula matriz 'die Hauptsache ist' y, más concretamente, sobre su forma monolexemática 'Hauptsache'. A diferencia del sustantivo homónimo, esta unidad no contribuye al contenido proposicional del enunciado que la alberga, sino que explicita relaciones y operaciones metadiscursivas de nivel textual. El análisis de un corpus de textos parl…