Search results for "longitudinal"
showing 10 items of 1501 documents
Brain-predicted age difference score is related to specific cognitive functions: A multi-site replication analysis
2021
Abstract Brain-predicted age difference scores are calculated by subtracting chronological age from ‘brain’ age. Positive scores reflect accelerated ageing and are associated with increased mortality risk and poorer physical function. To date, however, the relationship between brain-predicted age difference scores and specific cognitive functions has not been systematically examined. First, applying machine learning to 1,359 T1-weighted MRI scans, we predicted the relationship between chronological age and voxel-wise grey matter data. This model was then applied to MRI data from three independent datasets, significantly predicting chronological age: Dokuz Eylul University (n=175), the Cogni…
A Longitudinal Study of Episodic and Semantic Autobiographical Memory in aMCI and Alzheimer’s Disease Patients
2021
Background: The main objective of this study was to analyze the evolution of autobiographical memory (both episodic and semantic) in patients with mild cognitive impairment, patients with Alzheimer’s disease, and a healthy control group. We compared these groups at two time points: first, at baseline, and in a follow-up after 18 months. Method: Twenty-six healthy older adults, 17 patients with mild amnestic cognitive impairment, and 16 patients with Alzheimer’s disease, matched on age and educational level, were evaluated at both time points with the Autobiographical Memory Interview. Results: The results showed significant longitudinal deterioration in episodic and semantic autobiographica…
Quality of life before and after total laryngectomy: Results of a multicenter prospective cohort study
2013
Background The purpose of this study was to determine what quality of life (QOL) areas improve and deteriorate during the first year after total laryngectomy and to identify predictors of these changes. Methods One hundred seventy-four patients completed the European Organization for Research and Treatment of Cancer (EORTC) QOL questionnaires before laryngectomy, n = 133 before discharge from hospital, n = 110 at the end of rehabilitation, and n = 86 1 year after laryngectomy. Multivariate regression analysis was performed to estimate the effect of potential predictors on QOL. Results Areas that did not recover to baseline level were physical functioning, role functioning, social functionin…
Youthful smoking and drinking in a longitudinal perspective.
1982
The incidence and continuity of smoking and drinking, precursory social-behavioral characteristics of smokers and drinkers, and life conditions related to smoking and drinking are described. The study was part of an extensive Finnish longitudinal study of social development, the original sample of which consisted of 8-year-old subjects (196 boys, 173 girls) studied in 1968 by employing peer nomination and teacher ratings. The follow-up studies were made at ages 14 and 20. 154 Ss at age 14 and 135 Ss at age 20 were interviewed about their smoking and drinking habits, among others. The results showed that about 20% of the subjects smoked at age 14 and about 30% at age 20. The proportion of ab…
Platelet-Rich Plasma (PRP) in Dental Extraction of Patients at Risk of Bisphosphonate-Related Osteonecrosis of the Jaws: A Two-Year Longitudinal Study
2020
: Dental extraction has often been described as the main trigger event of osteonecrosis of the jaws (ONJ). This longitudinal hospital-based study aimed to evaluate the outcome at 2 years of a standardized medical-surgical protocol for dental extraction, combined with platelet rich-plasma (PRP) application, compared with conventional protocol not combined with PRP or any other autologous platelet concentrate in cancer (ONC) and osteometabolic (OST) patients, at risk of bisphosphonate (BP)-related ONJ. Twenty patients were consecutively recruited: six received BPs for cancer skeletal-related events (34.17 ±
Boosting Reading Fluency: An intervention case study at subword level
2007
This study is an intervention case study of fluency in Finnish‐speaking children with dyslexia. Two 7‐year‐old children, a girl and a boy, were selected from the Jyvaskyla Longitudinal Study of Dyslexia. The intervention emphasised syllables as reading units, and proceeded from reading syllables to reading words and text. Letter knowledge, reading skills (syllables, words, pseudowords, and text reading), and syllable segmentation of words were measured before, immediately after, and three months after the intervention. The results showed that the intervention mainly affected fluency at the syllable level. The girl also showed some improvements in fluency (accuracy, speed) at the word and te…
The role of work-related personal projects during two burnout interventions: a longitudinal study
2004
Burnout is nowadays a common problem among employees, and a new approach to reduce its extent is needed. This study looked at burnout interventions in terms of personal goals and/or projects. These represent what individuals are striving to achieve, and include work-related goals. Our aim was to examine the extent to which two kinds of burnout intervention, in the form of different types of psychotherapy, influence employees’ personal projects. The two types of therapy were psychoanalytic and experiential, both in the form of group therapy. To determine the extent, 62 employees who had contacted the Helsinki Occupational Health Services suffering from severe burnout participated, in the cou…
Toward an understanding of a healthy organizational change process : A three-wave longitudinal study among university employees
2019
This study aimed to improve our understanding of what constitutes a healthy organizational change process among university employees. Positive attitudes and proactive participation toward organizational change were presumed to affect and be affected by personality resources measured via core self-evaluations and work-related motivational well-being (vigor). The study used 3-wave longitudinal data collected in 2 large Finnish universities during their recent process of organizational change (N = 926). Structural equation modeling was used to establish the direction of the relationships between the variables. The results showed that high levels of both core self-evaluations and vigor were ass…
Changes in personal work goals in relation to the psychosocial work environment: A two-year follow-up study
2011
Associations between changes in the psychosocial work environment and changes in personal work goals were investigated in a two-wave, two-year longitudinal study. Psychosocial work environment was studied within the context of the Effort–Reward Imbalance model (ERI; Siegrist, 1996). The participants consisted of 423 young Finnish managers. Their most important personal work goals were categorized into seven content categories of competence, progression, well-being, job change, job security, organization, and finance at both measurement times. There were differences, especially in changes in the career opportunities factor of reward, between participants whose goals changed during the study.…
Behavioral and Brain Measures of Morphological Processing in Children With and Without Familial Risk for Dyslexia From Pre-school to First Grade
2021
School-age reading skills are associated with and predicted by preschool-age cognitive risk factors for dyslexia, such as deficits in phonological awareness, rapid automatized naming, letter knowledge, and verbal short-term memory. In addition, evidence exists that problems in morphological information processing could be considered a risk factor for dyslexia. In the present study, 27 children at pre-school age and the same 27 children at first grade age performed a morphological awareness task while their brain responses were measured with magnetoencephalography. Our aim was to examine how derivational morphology in Finnish language, and concomitant accuracy and reaction times are associat…